Aggressive Keratoacanthoma and Internal Malignant Neoplasm

Giant Keratoacanthoma of the Nasal Vestibule

“…The Grizybowski, or eruptive, form has a more widespread distribution and involves the palms or mucosal surfaces; there are usually many present at one time 5 . An association between multiple keratoacanthomas and internal malignant neoplasms exists 7 . A triad of multiple internal malignant conditions, sebaceous proliferations and keratoacanthoma is known as the Muir‐Torre syndrome 8 …”

The Muir-Torre Syndrome: A Disease of Sebaceous and Colonic Neoplasms

“…Other reports link internal ma lignancy with the appearance of keratoacanthomas. in the absence of sebaceous neoplasms [29][30][31][32][33]. One patient with intestinal polyps and a markedly positive family history of colon cancer developed sebaceous adenomas and a keratoacanthoma following iatrogenic immunosuppres- sion.…”

“…17 (43%) had at least one keratoacanthoma (table I). Several cases of keratoacanthoma in associ ation with visceral malignancy, but without the presence of sebaceous adenoma, have also been reported [29][30][31][32][33]. The association of both keratoacanthomas and sebaceous neoplasms in this syndrome may be explained by their common derivation from pilosebaceous follicles [36].…”

Multinodular keratoacanthoma and T cell lymphoma

“…The hnk between KA and immunosuppression is now well established, whatever its origin: lymphoma as described by Cabotin et al [26], iatrogenic immunosuppression after renal transplantation as described by Guillot et al [27] or Washington et al [28]. Claudy et al reported a ease of KA associated with a deficit in eellular immunity [29], whereas the combination of KA and visceral carcinoma has been reported both within the eontext of Torre's syndrome [30] and in isolation [31]. Other causes have also been suggested, sueh as genetic influences [32], injuries [32], contact with a virus [33] or exposure to the sun.…”