AggressiveKRASmutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroids
Theresia Mair,
Philip König,
Milena Mijović
et al.
Abstract:Transforming growth factor beta (TGF-β) exhibits complex and context-dependent cellular responses. While it mostly induces tumor-suppressive effects in early stages of tumorigenesis, its tumor promoting properties are evident in advanced disease. This TGF-β duality is still not fully understood, and whether TGF-β supports invasion and metastasis by influencing cancer cells directly, or rather through the stromal tumor compartment remains a matter of debate. Here, we utilized a library of colorectal cancer (CRC… Show more
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