Aggressive growth and neoplastic potential of odontogenic cysts.With special reference to central epidermoid and mucoepidermoid carcinomas

Eversole, Lewis R.; Sabes, William R.; Rovin, Sheldon

doi:10.1002/1097-0142(197501)35:1<270::aid-cncr2820350134>3.0.co;2-y

Cited by 265 publications

(83 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One theory is that central MECs arise from ectopically displaced benign salivary tissue [1,4,5]. A second theory is that central MECs arise from preexisting benign odontogenic cysts [1,2,4,21]. In light of significant morphologic overlap, GOC in particular has been identified as a likely progenitor for central MEC [2,18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Bishop

Yonescu

Batista

et al. 2014

Head and Neck Pathol

View full text Add to dashboard Cite

Glandular odontogenic cyst (GOC) is a cyst of the gnathic bones that is characterized by squamous and glandular differentiation. The histopathologic features of GOC overlap considerably with central mucoepidermoid carcinoma (MEC), suggesting that GOC could be a precursor lesion to, or even a low-grade form of, central MEC. Differentiating the two lesions may be difficult or impossible on a limited biopsy. MAML2 rearrangements have been recently found to be specific for MEC, even those arising in the jaws. An analysis of MAML2 in GOCs could help clarify its relationship with central MEC. Tissue blocks from 21 GOCs and 5 central MECs were retrieved from the surgical pathology archives of The Johns Hopkins Hospital. Each MEC exhibited solid areas and clear-cut stromal invasion. In addition, 4 of the MECs demonstrated cystic areas that were histologically similar to GOC. Breakapart fluorescence in situ hybridization for MAML2 was performed. For the MECs, analysis was performed on both the solid components and the cystic areas that resembled GOC. MAML2 rearrangements were identified in all 5 of the MECs, but in none of the 21 GOCs (100 vs. 0 %; p \ 0.0001, Fisher's Exact). In the MECs, the rearrangement was present in both the solid and GOC-like cystic areas. While central MECs consistently harbor the MAML2 rearrangement, even in low-grade cystic areas that resemble a pre-existing GOC, true GOCs do not. Accordingly, GOC does not appear to represent an early or low-grade form of central MEC, but rather an unrelated lesion. The high sensitivity and specificity of MAML2 rearrangement for MECs points to its utility as a diagnostic adjunct in separating mucinous cystic lesions of the gnathic bones.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Although not always easy on morphologic grounds, distinguishing GOC from central MEC is important because MECs have a higher rate of recurrence, carry a potential to metastasize to regional lymph nodes, and can in some cases be lethal [1,4,5,21,22].…”

Section: Introductionmentioning

confidence: 99%

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Bishop

Yonescu

Batista

et al. 2014

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Their intraosseous development is rare and not infrequently associated with early diagnostic and management difficulties [2]. The histogenesis of intraosseous MEC is uncertain, but an origin from ectopic salivary tissue or metaplastic transformation of odontogenic epithelium has been proposed [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Case reports and review articles of such an occurrence show that they typically present at relatively young age, more in female than male patients, with the most common symptoms being pain and swelling [2,3,[5][6][7]. Radiologically, these lesions show unilocular or multilocular wellcircumscribed radiolucency, though variable radiological patterns have been reported [8].…”

Section: Introductionmentioning

confidence: 99%

Central Mucoepidermoid Carcinoma, A Case Report with Molecular Analysis of the TORC1/MAML2 Gene Fusion

Khan

Loya

Azhar

et al. 2010

Head and Neck Pathol

View full text Add to dashboard Cite

Mucoepidermoid carcinoma is the most common salivary gland malignancy. The majorities of these tumors arise in the parotid and minor salivary glands, but may rarely develop intraosseously. The latter is not uncommonly associated with diagnostic and management difficulties. We report an example of intraosseous mucoepidermoid carcinoma with positive TORC1/MAML2 gene fusion transcript and discuss the clinical implications.

show abstract

“…Certain types of odontogenic cysts, such as residual cysts, dentigerous cysts and keratocystic odontogenic tumors, tend to undergo malignant transformation (13,39,40). As described in Table I, although odontogenic keratocysts, which include orthokeratinized and parakeratinized variants, exhibited the highest incidence among odontogenic cysts, several reports have previously revealed the exact types of odontogenic cysts associated with malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Primary intraosseous squamous cell carcinoma derived from a maxillary cyst: A case report and literature review

Morita

Yamashiro

Kayamori

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant central jaw tumor derived from odontogenic epithelial remnants. PIOSCC predominantly affects the mandible, although both jawbones may be involved. This case report describes a PIOSCC type 2 of the maxilla in a 37-year-old man, treated by partial maxillectomy. Histopathologically, the tumor was diagnosed as PIOSCC derived from an odontogenic cyst. Postoperatively, the patient has been followed up for 53 months, with no recurrence of the disease. We herein describe the clinical details, treatment results and histopathological characteristics of a rare case of PIOSCC derived from a maxillary odontogenic cyst with reference to the relevant literature. IntroductionPrimary intraosseous squamous cell carcinoma (PIOSCC) is a central jaw carcinoma derived from odontogenic epithelial remnants. PIOSCC is defined as a SCC arising within the jaw, and it has no initial connection with the oral mucosa. This tumor was first described by Loos (1) in 1913 as a central epidermoid carcinoma of the jaw. Willis (2) renamed the tumor as intraalveolar epidermoid carcinoma in 1948. In 1972, Pindborg et al (3) suggested the term primary intraosseous carcinoma (PIOC) and classified the lesion as an odontogenic carcinoma. Subsequently, the classification of odontogenic carcinomas was modified in several studies (4-6). In 2005, Eversole et al (7) introduced the term 'primary intraosseous SCC' (PIOSCC) and further categorized this entity into 3 types: Type 1 for solid tumors, type 2 for carcinomas arising from odontogenic cysts and type 3 for carcinomas associated with odontogenic tumors.In PIOSCC type 2, an SCC results from malignant transformation of an odontogenic cyst. To establish the presence of such malignant transformation, certain diagnostic criteria must be fulfilled (8). The estimated incidence of PIOSCC type 2 has been shown to range from 0.1 to 1.8% of all oral cancers (9-12). Bodner et al analyzed 116 reported cases of PIOSCC arising in an odontogenic cyst and found that the tumors predominantly affected the mandible, whereas the maxilla was affected in 21% of the cases (13).We herein report a case of PIOSCC derived from a maxillary odontogenic cyst. We have also reviewed the literature for cases of PIOSCC arising from maxillary cysts, including keratocystic odontogenic tumors, with respect to the diagnosis, prognosis and treatment of these tumors. Written informed consent was obtained from the patient for the publication of his case details. Case reportIn August, 2010, a 37-year-old Japanese man visited the Department of Oral Surgery in another hospital, with a 4-month history of a painful swelling in the left maxillary gingiva. Following clinical examination, the patient was diagnosed with apical periodontitis and antibiotics were prescribed; however, no improvement was noted. In October, 2010, the patient presented with a fistula in the left maxillary gingiva. A computed tomography (CT) scan revealed an area of bone resorption in the lateral ...

show abstract

Aggressive growth and neoplastic potential of odontogenic cysts.With special reference to central epidermoid and mucoepidermoid carcinomas

Cited by 265 publications

References 50 publications

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Glandular Odontogenic Cysts (GOCs) Lack MAML2 Rearrangements: A Finding to Discredit the Putative Nature of GOC as a Precursor to Central Mucoepidermoid Carcinoma

Central Mucoepidermoid Carcinoma, A Case Report with Molecular Analysis of the TORC1/MAML2 Gene Fusion

Primary intraosseous squamous cell carcinoma derived from a maxillary cyst: A case report and literature review

Contact Info

Product

Resources

About