Aggressive behavior of Her-2 positive colloid breast carcinoma: A case report in a metastatic breast cancer

Anwar, Sumadi Lukman; Dwianingsih, Ery Kus; Avanti, Widya Surya; Choridah, Lina; Suwardjo,; Aryandono, Teguh

doi:10.1016/j.amsu.2020.02.010

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…Demographic variables were distributed evenly among intrinsic breast cancer subtypes ( Table 1). Diagnosis of breast cancer in women younger than 40 years old correlated with a higher risk of metastasis (Table 3and 4) confirming our previous report of aggressive behavior in younger patients [27,28]. In relation to distant metastasis, younger age and late menopause were associated with increased risks and the odds ratio was higher in the luminal subtype for women younger than 40 years old and in TNBC for women with menopause older than 50 years old.…”

Section: Discussionsupporting

confidence: 86%

Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia

et al. 2020

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Background: More than one third of breast cancer patients including those that are diagnosed in early stages will develop distant metastasis. Patterns of distant metastasis and the associated risks according to the molecular subtypes are not completely revealed particularly in populations of patients with delayed diagnosis and advanced stages. Methods: Breast cancer patients (n = 1304) admitted to our institute (2014-2017) were evaluated to identify the metastatic patterns and the associated risks. Metastatic breast cancers at diagnosis were found in 245 patients (18.7%), and 1059 patients were then grouped into non-metastatic and metastatic groups after a median follow-up of 3.8 years. Results: Infiltration of the tumor to the skin and chest wall prevailed as the most powerful predictor for distant metastasis (OR 2.115, 95% CI 1.544-2.898) particularly in the luminal Alike subtype (OR 2.685, 95% CI 1.649-4.371). Nodal involvement was also significantly associated with the risk of distant metastasis (OR 1.855, 95% CI 1.319-2.611), and the risk was higher in the Luminal Alike subtype (OR 2.572, 95% CI 1.547-4.278). Luminal Alike subtype had a significant higher risk of bone metastasis (OR 1.601, 95% CI 1.106-2.358). In respect to treatment, a combination of anthracyclines and taxanes-based chemotherapy was significantly associated with lower distant organ spread in comparison with anthracycline-based chemotherapy (OR 0.510, 95% CI 0.355-0.766) and the effect was stronger in Luminal Alike subtype (OR 0.417, 95% CI 0.226-0.769). Classification into Luminal and non-Luminal subtypes revealed significant higher risks of bone metastasis in the Luminal subtype (OR 1.793, 95% CI 1.209-2.660) and pulmonary metastasis in non-Luminal breast cancer (OR 1.445, 95% CI 1.003-2.083).

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Section: Discussionsupporting

confidence: 86%

Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia

et al. 2020

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“…According to the clinical characteristics of primary cancer, patients with bilateral breast cancer were more frequently diagnosed in more advanced diseases, although the significant association was found only in the tumor size (T status, Table 3 ). Our last results might indicate the involvement of metastatic process of cancer cells in the development of contralateral cancer because the risk factors are overlapping with risks of distant spread as shown in our previous report [ 8 , 15 ]. However, some studies reported a lack of association between advanced tumor and risk of bilateral cancer [ 5 , 12 , 16 ].…”

Section: Discussionsupporting

confidence: 74%

Clinical characteristics and the associated risk factors of the development of bilateral breast cancers: A case-control study

Anwar

Prabowo

Avanti

et al. 2020

Annals of Medicine and Surgery

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Background The clinical impacts of bilateralism on prognosis and clinical decision-making remain contradictory particularly in areas with low incidence and delayed diagnosis of primary breast cancer. Identification of women at risk of bilateral breast cancer is required to improve patient management and to design the appropriate surveillance. Methods A total of 1083 women were enrolled and analyzed for the presence of synchronous and metachronous bilateral breast cancer as cases and unilateral breast cancer as controls during the median follow-up of 4.8 years. Results The incidence of bilateral breast cancer was 7.5% (81 of 1083). In comparison with unilateral breast cancers, bilateral cases were significantly diagnosed in younger women ( P = 0.037, mean age was 35.6 years) who had a larger tumor size ( P = 0.012, mean tumor size was 8 cm in diameter). Histological type of lobular cancer was identified as one of the risk factors for the development of contralateral breast cancer (OR 5.564, 95% CI: 3.219–9.620) and synchronous bilateral breast cancer (OR 2.561, 95% CI: 1.182–5.550). Bilateral breast cancer had significantly shorter progression-free survival (Mean survival was 26.6 vs 52.5 months for bilateral and unilateral breast cancers, respectively; P = 0.001) and shorter time to develop distant metastasis (Mean survival was 41.7 vs 104 months for bilateral and unilateral breast cancers, respectively; P = 0.001). Conclusion Patients with first primary breast tumors with lobular histological type and advanced stages were observed to have higher risks for the development of contralateral breast cancers.

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“…In addition, the standard adjuvant treatment after surgery was not delivered due to loss of follow-up for 4 years until the presentation of distant metastasis. Our case also reflects the complexity of sociocultural factors in the management of breast cancer in LMICs, in which low cancer awareness, a misconception concerning cancer treatments and cures, and barriers to accessing medical treatment are associated with delayed diagnosis, late-stage presentation, and a higher risk of metastasis [ 17 – 20 ]. Similar factors are associated with low and non-adherence to medical treatment of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Concurrent manifestations of Horner’s syndrome and esophageal metastasis of breast cancer: case report of a young woman after a period of non-adherence to treatment: a case report

et al. 2021

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Background Esophageal involvement and Horner’s syndrome are rare manifestations of breast cancer distant metastases that can pose a significant challenge in diagnosis and treatment. In addition to the more aggressive behavior of breast cancer diagnosed in young women, non-adherence to treatment is associated with increased risk of distant metastasis. Case presentation A 36-year-old Javanese woman presented to our institution with dysphagia, hoarseness, and frequent hiccups. In the 6 weeks prior to the current admission, the patient also reported tingling in the neck and shoulder, anhidrosis in the left hemifacial region, and drooping of the upper left eyelid. She was previously managed as tuberculoid laryngitis. Plain X-rays showed burst fractures of the cervical vertebrae and slight pleural effusion. Laryngoscopy revealed bowing of the vocal cords and liquid residue in the vallecula that was reduced upon chin tuck. Esophageal metastasis was confirmed with endoscopy showing thickening of the wall and positive cytology swab with ductal malignant cells. The patient had a history of breast cancer with a period of loss to follow-up of 4 years. Conclusions Physicians should consider potential distant metastasis of breast cancer to the esophagus and sympathetic nervous system of the neck particularly in a high-risk woman with presentation of dysphagia and manifestations of Horner’s syndrome.

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Aggressive behavior of Her-2 positive colloid breast carcinoma: A case report in a metastatic breast cancer

Cited by 8 publications

References 19 publications

Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia

Risk factors of distant metastasis after surgery among different breast cancer subtypes: a hospital-based study in Indonesia

Clinical characteristics and the associated risk factors of the development of bilateral breast cancers: A case-control study

Concurrent manifestations of Horner’s syndrome and esophageal metastasis of breast cancer: case report of a young woman after a period of non-adherence to treatment: a case report

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