Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases

Subjectively Perceived Side-Effects of Anti-Epileptic Drugs in Chronic Refractory Epilepsy

“…Note however that the percentage explained variance is low, indicating that the complaints are also related to other factors, in this group probably the epilepsy. The mood complaints of patients using LEV treatment were an essential factor in our study and are in line with a number of studies and meta-analyses [27][28][29][30]. LEV had an adverse event profile within the range of the other older drugs like PHT but with a different profile; self-reported anger and hostility were particularly frequent [13,15].…”

Levetiracetam use in critically ill patients

“…Thus, LEV use is particularly attractive in the setting of traumatic brain injury due to its minimal cognitive effects. Another explanation for these somewhat unusual findings may be that LEV has been reported to cause or worsen behavioral and mood problems in patients with preexisting psychiatric or psychological problems [35,36] but a recent analysis of the data from randomized trials questioned these findings [37]. If LEV actually worsens morbidity, it may not be an appropriate agent for empiric anticonvulsant use after traumatic brain injury.…”

Levetiracetam in combined therapy for focal epilepsy: experience with 80 patients

“…Psychische Nebenwirkungen bis hin zu stationär behandlungsbedürftigen paranoiden Psychosen stellen eine relevante Nebenwirkung von LEV dar, die in der hier behandelten Patientengruppe im Gegensatz zu einem Teil anderer Berichte [8,12,27] überwiegend nicht milde waren, bei mehreren Patienten stationär behandelt werden mussten und am häufigsten zum Absetzen der Medikation führten [13,15]. In einer Analyse von Studiendaten wiesen Cramer et al [12] darauf hin, dass andere Antikonvulsiva der 2.…”