Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropin-releasing hormone agonist therapy

McCluggage, W. Glenn; Jamieson, Timothy A.; Dobbs, Stephen; Grey, Alistair

doi:10.1016/j.ygyno.2005.09.033

Cited by 114 publications

(58 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are sporadic reports on using gonadotropin-releasing hormone (GnRH) analogs for the preoperative reduction of AAM and prevention of postoperative recurrence (12)(13)(14)(15). However, there have been no reports of their use for the treatment of AMFB.…”

Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Shoji

Takeshita

Mukaida

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract.A 50-year-old woman (gravida 2, para 2) first noticed a small nodule in the right labium majus 2 years prior to the initial visit to the Hachinohe Red Cross Hospital (Hachinohe, Japan), which had gradually increased in size. On physical examination, a well-circumscribed, elastic, firm, goose egg-sized, subcutaneous mass protruding from the right labium majus was identified. On magnetic resonance imaging (MRI), the lesion was hypointense on T1-weighted images and was well-circumscribed, strongly enhanced and homogeneous on gadolinium-enhanced images, measuring 7.5x4 cm. The same tumor had measured 2.6 cm on an MRI performed 6 years earlier. Based on the clinical course and imaging findings, angiomyofibroblastoma was diagnosed and surgical resection of the tumor was performed. The tumor was well-circumscribed and highly vascular. The intraoperative blood loss was 70 ml. Histopathologically, the tumor cells were concentrated around blood vessels, were spindle-shaped to oval with mild atypia, and were positive for vimentin, desmin, neural cell adhesion molecule (N-CAM), CD-34, estrogen receptor and progesterone receptor, and negative for S-100. Based on these findings, the diagnosis of angiomyofibroblastoma was confirmed. Angiomyofibroblastoma is a benign mesenchymal tumor that occurs in the female external genitalia. Differentiation of this tumor from aggressive angiomyxoma, a fast-growing infiltrative malignancy that occurs in the same region, may be challenging. The diagnosis of angiomyofibroblastoma is usually based on the histopathological findings of the resected specimen. The present case is of value, as the angiomyofibroblastoma was successfully diagnosed preoperatively based on the clinical course and imaging findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma of the vulva diagnosed preoperatively: A case report

Shoji

Takeshita

Mukaida

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…In view of the positive ER and PR status of some AAMs, primary treatment with GnRH agonists has been carried out successfully. 9 For example, McCluggage et al reported the case where after tumorectomy of the right vulva residual pelvic tumour was treated with 3.6 mg goselerin acetate once a month. Complete resolution on magnetic resonance imaging was achieved after 8 months of treatment, with no recurrence after 1 year.…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of a rare tumour: aggressive angiomyxoma

Rudra¹,

Bajaj²

2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

“…Surgical excision is the treatment of choice, although treatment with gonadotropin-releasing hormone agonists (Leuprolide) is an emerging therapy [7].…”

Section: Discussionmentioning

confidence: 99%