Aggressive and fatal statin-induced dermatomyositis: a case report

Chemello, Raíssa Massaia Londero; Benvegnú, Ana Maria; Dallazem, Lia Natália Diehl; Chemello, Diego

doi:10.1093/omcr/omx063

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Statin‐induced DM has an age range of 44–76 years with no apparent predilection for sex. The onset of DM after initiation of statin therapy is nonspecific, with presentation as early as 3 days following treatment initiation to as long as 6 years after …”

Section: Methodsmentioning

confidence: 78%

“…One case was reported to result in death from complications of pulmonary fibrosis . The second involved death from complications of dysphagia, leading to aspiration pneumonia and sepsis and eventual death during hospitalization after 2 months of being diagnosed with statin‐induced DM . Otherwise, the majority of cases demonstrated a self‐limiting course with eventual resolution.…”

Section: Methodsmentioning

confidence: 99%

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Statin‐induced dermatomyositis for the practicing dermatologist: a review of the literature

2019

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Statins cause a spectrum of muscle-related adverse events, including autoimmune myopathies such as dermatomyositis (DM). This review aims to describe the events of statin-induced DM and amyopathic dermatomyositis (ADM) to increase awareness for practicing dermatologists about harmful interactions with the most commonly prescribed lipid-lowering medication. PubMed was searched for relevant literature related to statininduced DM and ADM. Numerous cases of statin-induced DM have been reported in individuals with no history of DM or other autoimmune conditions. Statins also cause ADM, although this is a rare association. Because of the widespread use of statins worldwide for atherosclerotic disease prevention, it may be of benefit to practicing dermatologists and all clinicians to assess for a history of DM when prescribing statins and inquire if patients with a DM-like presentation are taking or have taken a statin medication.ª

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Section: Methodsmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

Statin‐induced dermatomyositis for the practicing dermatologist: a review of the literature

2019

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“…DM has been known to be an iatrogenic, autoimmune, and a paraneoplastic syndrome. Several previous cases of statininduced DM have been reported in the literature with courses ranging from relatively benign to fatal [1]. We present the case of a patient with atorvastatin-induced DM.…”

Section: Introductionmentioning

confidence: 90%

“…Statins are generally well tolerated and safe, making them an excellent choice in therapy. However, there are common instances of statin-induced myalgias and rare instances of moderate-to-severe cases of statin-induced myopathies [1][2][3][4][5][6]. Statin-induced myopathy consists of a spectrum of disease conditions including polymyositis (PM), dermatomyositis (DM), and immune-mediated necrotizing myositis (IMNM).…”

Section: Introductionmentioning

confidence: 99%

Weak Knees: A Case of Atorvastatin-induced Dermatomyositis

Gutierrez

Faraji

Pacheco

2020

Cureus

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HMG-CoA reductase inhibitors (statins) are one of the most widely used medications in the primary care setting, and like any medications they have many side effects. The common ones include myalgias and rare ones include dermatomyositis. Here we present the case of atorvastatin-induced dermatomyositis with an unfortunate progression. This mandates a low threshold for first contact doctors to screen their patients for new-onset muscle weakness and rash after starting a statin recently, like our patient who had started atorvastatin several months before. This case adds to the previously reported cases and provides further evidence for statins being triggers of immune-mediated disease. The appropriate management of this condition requires a collaborative effort involving clinical judgment, laboratory testing, and imaging.

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“…In this context, some cases of association of statins with polymyositis [3][4][5][6][7][8][9][10][11][12][13][14][15][16] and with dermatomyositis [10][11][12]15,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] have been described.…”

mentioning

confidence: 99%

Polymyositis, Dermatomyositis, and Statins: A Review

Turrin

2019

CMI

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BACKGROUND: Statins are a well-recognized cause of a variety of skeletal myopathic effects, which generally resolve when discontinuing the treatment. Among autoimmune manifestations associated with statins, there are typical polymyositis (PM) and typical dermatomyositis (DM). OBJECTIVE: To perform a review on published case reports and case series about statin-associated PM and DM. METHODS: This literature comprehensive search was conducted mainly on PubMed, but also congress abstracts and university websites were considered. Given the paucity of cases, the search was extended to include articles in all languages with English abstract. RESULTS: Twenty-eight PM and 30 DM cases have been described with prevalence in female (64%) and senile age. The drugs most frequently involved were atorvastatin and simvastatin. The differential diagnosis should be made among the main myositis subtypes: immuno-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and overlap syndrome with myositis (OM), including anti-synthetase syndrome (ASS). CONCLUSIONS: Even though the onset of polymyositis or dermatomyositis is a rare phenomenon, it is advisable to consider their presence in patients taking statins and with a non-reversible elevation of creatine phosphokinase. Polimiosite, dermatomiosite e statine: una reviewCMI 2018; 12(1): 89-102 https://doi.org/10.7175/cmi.v12i1.1364

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Aggressive and fatal statin-induced dermatomyositis: a case report

Cited by 8 publications

References 12 publications

Statin‐induced dermatomyositis for the practicing dermatologist: a review of the literature

Statin‐induced dermatomyositis for the practicing dermatologist: a review of the literature

Weak Knees: A Case of Atorvastatin-induced Dermatomyositis

Polymyositis, Dermatomyositis, and Statins: A Review

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