Aggrenox (Asasantin retard)‐induced Stevens–Johnson syndrome

Jao, Tun; Tsai, Tsung‐Hua; Jeng, Jiann‐Shing

doi:10.1111/j.1365-2125.2008.03340.x

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…Stevens–Johnson syndrome is a rare, life-threatening, and severe blistering mucocutaneous disease, most commonly caused by drugs. [ 2 ]…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of SJS is estimated to be between 1.1 and 7.7 cases per million, with 16% of cases showing a past history of short-term use of the anti-epileptic drug. [ 2 ] Lamotrigine is an analog of phenyltriazine class, a potential anti-epileptic drug, which is known to cause SJS, strengthening the probable association between lamotrigine and SJS. [ 5 9 ] The risk of skin reactions is increased when the starting dose of lamotrigine is high when the dose is increased rapidly and when used in combination with valproate.…”

Section: Discussionmentioning

confidence: 99%

“…In 1940, it was commonly called as “Steven–Johnson's syndrome (SJS).”[ 1 ] SJS, is a serious mucocutaneous illness with systemic symptoms characterized by the presence of flat, atypical target lesions, and epidermal detachment encompassing <10% of the total body surface area with two or more mucosal sites affected usually. [ 2 ] There are various factors, which precipitate this condition, including viral infections, medications, and systemic illness. [ 3 4 ] There are more than 200 drugs that have been associated with the development of SJS.…”

mentioning

confidence: 99%

“…The drugs such as antibiotics, anti-epileptics, and nonsteroidal anti-inflammatory drugs are the common agents responsible for SJS. [ 2 3 5 6 ]…”

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confidence: 99%

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Stevens-Johnson syndrome induced by a combination of lamotrigine and valproic acid

et al. 2015

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Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance.

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“…Stevens–Johnson syndrome is a rare, life-threatening, and severe blistering mucocutaneous disease, most commonly caused by drugs. [ 2 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…The drugs such as antibiotics, anti-epileptics, and nonsteroidal anti-inflammatory drugs are the common agents responsible for SJS. [ 2 3 5 6 ]…”

mentioning

confidence: 99%

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Stevens-Johnson syndrome induced by a combination of lamotrigine and valproic acid

et al. 2015

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“…Salava et al [ 35 ] reported on a female patient with generalized eczema under dipyridamole treatment and a positive patch test for type-IV sensitization. A case of dipyridamole-induced Stevens-Johnson syndrome has been reported in Taiwan [ 36 ].…”

Section: Antiplatelet Drugsmentioning

confidence: 99%

Hypersensitivity reactions to modern antiplatelet and anticoagulant drugs

Scherer

2015

Allergo J Int

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Anticoagulation and antiplatelet drugs are among the most commonly used medical drugs. In addition to the long-established heparins, hirudins, coumarins and antiplatelet drugs such as acetylsalicylic acid, numerous novel and predominantly synthetic pharmacologic agents have come onto the market in recent years. These new agents act at various sites in coagulation and have significantly broadened treatment options. Whilst immunological hypersensitivity reactions are on the whole rare, they have a considerable impact on patient management when they do occur. The present overview discusses the currently known hypersensitivity reactions to anticoagulant and antiplatelet agents, with particular attention to the newer substance classes including P2Y12 inhibitors, glycoprotein IIb/IIIb receptor antagonists, direct factor Xa inhibitors and direct thrombin inhibitors.

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