“…For instance, ribosome stalling that can occur due to stochastic perturbations of translation, mutations, or a number of biotic or abiotic fluctuations in the environment will lead to the aborted synthesis of a nascent polypeptide chains. These aborted polypeptides are recognized by the cellular surveillance machinery and modified by the addition of carboxy-terminal alanine and threonine residues (CAT tails) (Brandman et al, 2012;Kostova et al, 2017;Sitron, Park, & Brandman, 2017;Sitron, Park, Giafaglione, & Brandman, 2020;Sitron & Brandman, 2019). This, in turn, leads to their aggregation and targeted degradation through the sequestration of a group of specialized proteins called molecular chaperones that recognize the aberrant conformation of the CAT-tailed polypeptides (Sitron et al, 2017(Sitron et al, , 2020Sitron & Brandman, 2019).…”