Aggregation Mechanism of Ag Atoms Deposited on Liquid Surfaces

Zhang, Xiaofei; Zhang, Chuhang; Yang, Bo; Lv, Neng; Pan, Qifa; Ye, Gao-Xiang

doi:10.1143/jpsj.80.104603

Cited by 10 publications

(13 citation statements)

References 22 publications

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“…It can be seen that H increases with l first and then approaches a saturation value, and as N increases, H would be saturated more quickly, which is quite similar to the experimental observation. [22] The simulation result shown in Fig. 5 reveals that the diffusion step length may greatly influence the growth process of the clusters.…”

Section: Resultsmentioning

confidence: 97%

“…Based on the experimental observations, [15,22] the appropriate parameters are selected and the typical simulation images are shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

“…3 is in agreement with the experimental observations. [19,22] Obviously, N c increases with the critical size s c , and as shown in The average height of the aggregates, namely H, equals the average number of the particles on each occupied lattice site. The dependence between H and N is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Crossover from 2-dimensional to 3-dimensional aggregations of clusters on square lattice substrates

et al. 2015

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Section: Resultsmentioning

confidence: 97%

“…Based on the experimental observations, [15,22] the appropriate parameters are selected and the typical simulation images are shown in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

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Crossover from 2-dimensional to 3-dimensional aggregations of clusters on square lattice substrates

et al. 2015

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“…This phenomenon may be due to the internal condensation of Ag films during the growth process; when the film thickness increased from 1 to 5 nm, silver islands gradually formed and the number of islands continued to increase and thus the surface coverage increased significantly. As the thickness of the silver films further increased, silver islands tended to grow higher rather than wider, resulting in the almost unchanged film coverage. , …”

Section: Results and Discussionmentioning

confidence: 99%

Deposition of Ag Films on Liquid Substrates via Thermal Evaporation for Surface-Enhanced Raman Scattering

Sun

Wang

et al. 2020

ACS Omega

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Surface-enhanced Raman scattering (SERS) substrates were prepared by depositing Ag atoms on liquid surfaces via thermal evaporation at room temperature. These free-sustained substrates result in the formation of uniform Ag films, in which ramified Ag aggregates consist of substantial Ag nanoclusters with narrow gaps of several nanometers in between. SERS spectra of rhodamine 6G were investigated for this substrate to evaluate the SERS performance of this characteristic film morphology, and the results indicated that the SERS intensity from the closely-packed Ag nanostructures and small intervals were significantly enhanced. The dependence of SERS enhancement on the film thickness, nanoparticle size, and gap width was studied. An analytical model was proposed to simulate the electric field distribution during SERS detection, and the results validated the experimental observations.

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“…The Src kinases have multiple substrates that lead to diverse biological effects in cancer cells, including changes in proliferation, motility, invasion, survival and angiogenesis (10). Dasatinib suppresses tumor angiogenesis, invasion, and metastasis by inhibiting Src expression (11). Cardiovascular and hematologic toxicity are dose limiting for dasatinib; thus, it is necessary to develop new anticancer combination therapy with lower concentrations of dasatinib to avoid these major side-effects (12).…”

Section: Introductionmentioning

confidence: 99%

Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo

Zhang

Zhou

et al. 2013

Oncology Reports

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Abstract. The present study showed that the combination of dasatinib and combretastatin A-4 (CA-4) exhibited synergistic cytotoxicity in multiple types of cancer, including ovarian, hepatocellular, lung and prostate carcinoma. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis. A clear increase in γ-H2AX expression was observed in the dasatinib + CA-4 group compared with the mono-treatment groups, indicating that dasatinib plus CA-4 may induce double-strand breaks (DSBs) in HO-8910 cells. Moreover, the increased anticancer efficacy of dasatinib combined with CA-4 was further validated in a human HO-8910 ovarian cancer xenograft model in nude mice. Our study is the first to show that the combination of dasatinib with CA-4 could be a novel and promising therapeutic approach for the treatment of cancer. IntroductionCombretastatin A-4 (CA-4), a natural product isolated from the bark of a south african tree combretum caffrum, is a highly effective antiangiogenic agent that causes vascular shutdown, leading to tumor death (1). CA-4 phosphate (CA-4P), a water soluble pro-drug of CA-4, is rapidly dephosphorylated to the active compound CA-4 and shows reversible binding kinetics to tubulin, leading to disruption of microtubular structures (2,3). Although CA-4P is being studied in clinical trials as a vascular disrupting agent, cardiovascular toxicity and neurotoxicity are dose limiting for CA-4P (4,5). These severe side-effects currently represent the main obstacles to broad clinical application of CA-4P (2). Thus, it is important to develop new antitumor combination therapy with lower concentrations of CA-4 and more specificity for tumor endothelial cells than normal endothelial cells to avoid cardiac toxicity from endothelial damage.Tyrosine kinase inhibitors (TKIs) are rapidly being integrated into the management of a variety of malignant diseases (6). Dasatinib, a novel orally bioactive TKI currently used to treat patients with hematologic and solid malignancies, correlated with a combined targeting of PDGFR-β and VEGFR/c-Src signaling pathways (7-9). The Src kinases have multiple substrates that lead to diverse biological effects in cancer cells, including changes in proliferation, motility, invasion, survival and angiogenesis (10). Dasatinib suppresses tumor angiogenesis, invasion, and metastasis by inhibiting Src expression (11). Cardiovascular and hematologic toxicity are dose limiting for dasatinib; thus, it is necessary to develop new anticancer combination therapy with lower concentrations of dasatinib to avoid these major side-effects (12). Dasatinib has shown synergistic anticancer activity in combination with chemotherapeutic agents including paclitaxel, ixabepil...

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Aggregation Mechanism of Ag Atoms Deposited on Liquid Surfaces

Cited by 10 publications

References 22 publications

Crossover from 2-dimensional to 3-dimensional aggregations of clusters on square lattice substrates

Crossover from 2-dimensional to 3-dimensional aggregations of clusters on square lattice substrates

Deposition of Ag Films on Liquid Substrates via Thermal Evaporation for Surface-Enhanced Raman Scattering

Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo

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