Aggregation‐Induced Emission Macromolecular Materials for Antibacterial Applications

Zuo, Yunfei; Kwok, Ryan T. K.; Sun, Jianwei; Lam, James C.W.; Tang, Ben Zhong

doi:10.1002/marc.202300104

Cited by 9 publications

(2 citation statements)

References 71 publications

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“…In the face of the challenges posed by bacterial infections and drug resistance, achieving sensitive bacterial detection and monitoring the effectiveness of antibacterial treatments are the basis for accurate treatment of bacterial infections . Aggregation-induced emission (AIE) luminogens (AIEgens) are fluorescent probes which can be responsive to the bacterial microenvironment and enable accurate bacterial targeting, tracking, sterilization, and repair . Bioactive glass is an inorganic material exhibiting biological activity, characterized by exceptional biocompatibility and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

“… 32 Aggregation-induced emission (AIE) luminogens (AIEgens) 33 are fluorescent probes which can be responsive to the bacterial microenvironment and enable accurate bacterial targeting, tracking, sterilization, and repair. 34 Bioactive glass is an inorganic material exhibiting biological activity, characterized by exceptional biocompatibility and bioactivity. It can engage in chemical interactions with biological tissues, thereby facilitating tissue regeneration and wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

Lin,

Tan,

Deng

et al. 2024

ACS Omega

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Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial and powerful wound microenvironment regulation and protection function to promote wounds heal quickly. In this study, a multifunctional composite dressing (HA-AMP/SF/Alg/Rb-BG-AIEgens) was synthesized by combining a mesoporous bioactive glass framework loaded with AIEgens (Rb-BG-AIEgens) with cross-linked antimicrobial peptide grafted hyaluronic acid (HA-AMP), sodium alginate (Alg), and silk fibroin (SF). It is important to note that the Rb-BG-AIEgens can achieve real-time and sensitive bacterial detection. HA-AMP can achieve broad spectrum antibacterial and avoid the residue of drug-resistant bacteria. The HA-AMP/SF/Alg/Rb-BG-AIEgens dressing can up-regulate related proliferative proteins, thereby promoting regeneration of tissue and the rapid healing of chronic wounds. With good biocompatibility and antibacterial ability, HA-AMP/SF/Alg/Rb-BG-AIEgens dressing has great potential to become a next generation wound dressing for clinical biological fluid management and chronic bacterial infection treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

Lin,

Tan,

Deng

et al. 2024

ACS Omega

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Antibacterial Plasma Coating with Aggregation‐Induced Emission Photosensitizers to Prevent Surgical Site Infections

Sahu,

Ninan,

Nguyen

et al. 2024

Adv Materials Inter

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Surgical site infections (SSI) are major post‐operative complications following surgery. Reducing SSI is a global urgency as they account for huge pecuniary, physiological, and emotional burdens for patients. Antibiotic resistance is the main challenge for surgeons dealing with SSIs. Aggregation‐induced emission photosensitisers (AIE PS) with their distinct optical characteristics, biocompatibility, low toxicity, and target specificity, hold the potential for the treatment of SSI. Herein, a synergetic strategy combining plasma polymerization and AIE PS is adopted to develop coatings that can eradicate SSI‐causing bacteria. These coatings can preferentially kill Gram‐negative and Gram‐positive bacteria over mammalian cells after triggered by light irradiation. The cell viability and immunostaining studies confirmed their biocompatibility on mammalian cells. The antibacterial mechanistic studies explored their ability to generate reactive oxygen species (ROS), which is crucial for overcoming antibiotic resistance. Thus, this study opens an avenue toward antibacterial coatings to decrease the prevalence of SSI.

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Malleable, Ultrastrong Antibacterial Thermosets Enabled by Guanidine Urea Structure

Yu,

Li,

Liu

et al. 2024

Advanced Science

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Dynamic covalent polymers (DCPs) that strike a balance between high performance and rapid reconfiguration have been a challenging task. For this purpose, a solution is proposed in the form of a new dynamic covalent supramolecular motif—guanidine urea structure (GUAs). GUAs contain complex and diverse chemical structures as well as unique bonding characteristics, allowing guanidine urea supramolecular polymers to demonstrate advanced physical properties. Noncovalent interaction aggregates (NIAs) have been confirmed to form in GUA‐DCPs through multistage H‐bonding and π‐π stacking, resulting in an extremely high Young's modulus of 14 GPa, suggesting remarkable mechanical strength. Additionally, guanamine urea linkages in GUAs, a new type of dynamic covalent bond, provide resins with excellent malleability and reprocessability. Guanamine urea metathesis is validated using small molecule model compounds, and the temperature dependent infrared and rheological behavior of GUA‐DCPs following the dissociative exchange mechanism. Moreover, the inherent photodynamic antibacterial properties are extensively verified by antibacterial experiments. Even after undergoing three reprocessing cycles, the antibacterial rate of GUA‐DCPs remains above 99% after 24 h, highlighting their long‐lasting antibacterial effectiveness. GUA‐DCPs with dynamic nature, tuneable composition, and unique combination of properties make them promising candidates for various technological advancements.

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Aggregation‐Induced Emission Macromolecular Materials for Antibacterial Applications

Cited by 9 publications

References 71 publications

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

Antibacterial Antimicrobial Peptide Grafted HA/SF/Alg Wound Dressing Containing AIEgens for Infected Wound Treating

Antibacterial Plasma Coating with Aggregation‐Induced Emission Photosensitizers to Prevent Surgical Site Infections

Malleable, Ultrastrong Antibacterial Thermosets Enabled by Guanidine Urea Structure

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