Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications

Zhang, Xiqi; Tao, Lei; Chi, Zhenguo; Xu, Jiarui; Wei, Yen

doi:10.1039/c4tb00291a

Cited by 316 publications

(197 citation statements)

References 231 publications

(207 reference statements)

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“…In most RE 3 þ -activated phosphors, charge transfer transitions of RE 3 þ ions or host absorption are located in the UV region (150-300 nm) and their intra 4f-4f excitation peaks in NUV region (300-400 nm) are weak [16,17]. The strategy of sensitizing Tb 3 þ by Ce 3 þ can effectively solve the drawback with excitation spectral broadening and enhancement through the ET process from Ce 3 þ to Tb 3 þ ions.…”

Section: 2mentioning

confidence: 97%

“…In recent years, much research effort has been directed towards the synthesis of rare-earth (RE 3 þ ) doped functional materials since they can be used as highly efficient phosphors, catalysts, and optics materials by virtue of their unique optical, electronic, and chemical properties [1][2][3][4]. For applications involving NUV excitation (300-400 nm) for the generation of a variety of display panels, Tb 3 þ ion is a well-known activator that effectively emits green light in diverse host lattices.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced luminescence properties and energy transfer in Ce3+ and Tb3+ co-doped NaCaBO3 phosphor

Qin

Zhang

He³

et al. 2015

Ceramics International

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Section: 2mentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Enhanced luminescence properties and energy transfer in Ce3+ and Tb3+ co-doped NaCaBO3 phosphor

Qin

Zhang

He³

et al. 2015

Ceramics International

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“…In contrast to the dyes forming J-or H-aggregates, the nanoparticles made of dyes with enhanced emission show only the changes in intensity but not the spectral changes. The sensors based on such intensity changes of these dyes were suggested exploring aggregation-dissociation effect (Ding et al 2013 ;Zhang et al 2014 ).…”

Section: Fluorescent Nanoparticles Made Of Organic Dyes and Aggregatimentioning

confidence: 99%

Nanoscale Fluorescence Emitters

Demchenko

2015

Introduction to Fluorescence Sensing

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This chapter provides comparative analysis of properties of different nanoscale materials to absorb and emit visual and near-IR light with the focus on their applications in sensing and imaging technologies. Nowadays we observe that in these applications the novel nanoscale fl uorescent materials appear in strong competition with traditional organic dyes. They demonstrate diverse photophysical behavior and allow obtaining diverse information when they are incorporated into sensor composites or form the images in biological systems. Among these nanoscale emitters are the structures formed of organic dyes or by these dyes incorporated into different types of polymers with the resulting dramatically increased brightness. Collective excitonic effects appear when the aromatic units are coupled in conjugated polymers. Nanoscale structures formed of inorganic carbon in the form of nanodiamonds, graphene and graphene oxide pieces and the so-called carbon dots joined quite recently the family of fl uorophores. Semiconductor quantum dots present a range of bright emitters covering whole visible and near-IR spectral range. Finally, the up-converting nanocrystals make possible visible emission with near-IR excitation. Here we overview the most important features of these nanoscale materials. The following Chap. 6 will be focused on functional nanocomposites that allow extending the useful properties of these basic components.

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“…Very recently, we and others also found that several AIEgens show effi cient ROS production in aggregate state. [ 72,[80][81][82] These unique properties are ideal for mitochondria-targeted PDT as the accumulation of AIEgens in mitochondria or encapsulation of AIEgens by mitochondria-targeted nanocarriers will not compromise their fl uorescence and ROS generation.…”

Section: Introductionmentioning

confidence: 98%

Cellular and Mitochondrial Dual‐Targeted Organic Dots with Aggregation‐Induced Emission Characteristics for Image‐Guided Photodynamic Therapy

Feng

Qin

et al. 2015

Adv Healthcare Materials

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Targeted delivery of drugs toward mitochondria of specific cancer cells dramatically improves therapy efficiencies especially for photodynamic therapy (PDT), as reactive oxygen species (ROS) are short in lifetime and small in radius of action. Different from chemical modification, nanotechnology has been serving as a simple and nonchemical approach to deliver drugs to cells of interest or specific organelles, such as mitochondria, but there have been limited examples of dual-targeted delivery for both cells and mitochondria. Here, cellular and mitochondrial dual-targeted organic dots for image-guided PDT are reported based on a fluorogen with aggregation-induced emission (AIEgen) characteristics. The AIEgen possesses enhanced red fluorescence and efficient ROS production in aggregated states. The AIE dot surfaces are functionalized with folate and triphenylphosphine, which can selectively internalize into folate-receptor (FR) positive cancer cells, and subsequently accumulate at mitochondria. The direct ROS generation at mitochondria sites is found to depolarize mitochondrial membrane, affect cell migration, and lead to cell apoptosis and death with enhanced PDT effects as compared to ROS generated randomly in cytoplasm. This report demonstrates a simple and general nanocarrier approach for cellular and mitochondrial dual-targeted PDT, which opens new opportunities for dual-targeted delivery and therapy.

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Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications

Cited by 316 publications

References 231 publications

Enhanced luminescence properties and energy transfer in Ce3+ and Tb3+ co-doped NaCaBO3 phosphor

Enhanced luminescence properties and energy transfer in Ce3+ and Tb3+ co-doped NaCaBO3 phosphor

Nanoscale Fluorescence Emitters

Cellular and Mitochondrial Dual‐Targeted Organic Dots with Aggregation‐Induced Emission Characteristics for Image‐Guided Photodynamic Therapy

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