Aggregation behaviour of synthetic peptide surfactants

Artificial Enzymes

“…While micelles provide hydrophobic reaction sites effective for acceleration of various enzyme-mimetic reactions, those aggregates are generally soft and difficult to achieve conformational fixation of substrates for regio- and stereospecific reactions. Peptide surfactants bearing amino acid residue(s), such as 7 , developed by Murakami et al may improve such a weak aspect of micellar aggregates, since the amphiphiles tend to form tight aggregates relative to those formed with simple surfactants, originating from the intramicellar hydrogen-bonding interaction. − …”

“…Peptide surfactants bearing amino acid residue(s), such as 7, developed by Murakami et al may improve such a weak aspect of micellar aggregates, since the amphiphiles tend to form tight aggregates relative to those formed with simple surfactants, originating from the intramicellar hydrogen-bonding interaction. [34][35][36][37] It is well recognized that incorporation of substrate species into aqueous micelles proceeds through hydrophobic, electrostatic, and charge-transfer interactions. On the other hand, the hydrogen-bonding interaction between a substrate and a catalyst seems to be also effective for stereoselective catalysis in the hydrophobic micellar phases.…”