Aggregation behavior of the surfactant bearing pyrrolidinium head group in the presence of polyacrylic acid

Vasilieva, Elmira A.; Лукашенко, С. С.; Васильева, Л. А.; Pavlov, Rais; Gaynanova, Gulnara A.; Zakharova, L. Ya.

doi:10.1007/s11172-019-2390-x

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…Binary IA-12/PAA systems were studied by the variation of the amphiphile concentration and three fixed concentrations of polyelectrolyte (1, 3 and 5 mM). In accordance with our previous reports [41,42], a spontaneous pH of~4 occurs under these conditions, which corresponds to an~8% degree of polyelectrolyte ionization. This means that PAA can be specified as a weak polyelectrolyte bearing a negative charge.…”

Section: Mixed Systems Based On Ia-12 and Polyacrylic Acidsupporting

confidence: 93%

“…The latter is probably caused by the shift of the pK a value induced by micelles. Under these conditions, only~8% of carboxylic groups are ionized [41], which is probably responsible for the weak influence of the polyelectrolyte concentration on electrostatic interactions. Second, the charge behavior of the IA-12/PAA binary systems can be guided by a fine balance between several factors, including the variation in the solution pH as a function of the polymer and surfactant concentration and a shift in pK a values.…”

Section: Mixed Systems Based On Ia-12 and Polyacrylic Acidmentioning

confidence: 99%

“…This allo trolling the aggregation capacity and functional activity of the systems based Therefore, this study is devoted to the elucidation of the self-assembling beha practical potentiality of the systems based on imidazolium amphiphiles bearing a hydrophobic tail (IA-12, Figure 1) and two polyanions: (i) synthetic polyelectroly acrylic acid, PAA, Figure 1) and (ii) a DNA decamer (oligonucleotide). phiphile/polyelectrolyte, systems their aggregation characteristics in aqueous s were quantified under different surfactant concentrations and fixed polyelectro centrations in accordance with an earlier protocol [41].…”

Section: Introductionmentioning

confidence: 99%

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Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry, conductometry, dynamic and electrophoretic light scattering and fluorescent spectroscopy and microscopy. It has been established that PAA addition to the surfactant system resulted in a ca. 200-fold decrease in the aggregation threshold of IA-12, with the hydrodynamic diameter of complexes ranging within 100–150 nm. Electrostatic forces are assumed to be the main driving force in the formation of IA-12/PAA complexes. Factors influencing the efficacy of the complexation of IA-12 with oligonucleotide were determined. The nonconventional mode of binding with the involvement of hydrophobic interactions and the intercalation mechanism is probably responsible for the IA-12/oligonucleotide complexation, and a minor contribution of electrostatic forces occurred. The latter was supported by zeta potential measurements and the gel electrophoresis technique, which demonstrated the low degree of charge neutralization of the complexes. Importantly, cellular uptake of the IA-12/oligonucleotide complex was confirmed by fluorescence microscopy and flow cytometry data on the example of M-HeLa cells. While single IA-12 samples exhibit roughly similar cytotoxicity, IA-12–oligonucleotide complexes show a selective effect toward M-HeLa cells (IC50 1.1 µM) compared to Chang liver cells (IC50 23.1 µM).

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Section: Mixed Systems Based On Ia-12 and Polyacrylic Acidsupporting

confidence: 93%

Section: Mixed Systems Based On Ia-12 and Polyacrylic Acidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

et al. 2021

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“…Our early investigations demonstrated the complexation of cationic surfactants with pyrrolidinium and imidazolium head groups containing a hydroxyethyl moiety with PAA [ 52 , 53 ]. It was shown that the properties of polymer–colloid systems significantly depend on many factors, including the surfactant head group structure [ 18 ] and the presence of functional groups.…”

Section: Resultsmentioning

confidence: 99%

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

et al. 2023

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Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions.

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Control of the phase formation process in solutions of anionic polyelectrolyte—cationic surfactant complexes in a microfluidic channel

Bezrukov

Galyametdinov

2020

Russ Chem Bull

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Aggregation behavior of the surfactant bearing pyrrolidinium head group in the presence of polyacrylic acid

Cited by 10 publications

References 18 publications

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

Control of the phase formation process in solutions of anionic polyelectrolyte—cationic surfactant complexes in a microfluidic channel

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