Aggregation and Crosslinking of Poly(<i>N,N</i>‐dimethylacrylamide)‐<i>b</i>‐pullulan Double Hydrophilic Block Copolymers

Plucinski, Alexander; Willersinn, Jochen; Lira, Rafael B.; Dimova, Rumiana; Schmidt, Bernhard V. K. J.

doi:10.1002/macp.202070031

Cited by 5 publications

(4 citation statements)

References 60 publications

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“…The feature of our ultra-high-molar mass polyacrylamide w/ w emulsion system is relevant for application as water droplets and polymer-enriched phases are formed, similar to what we found in previous studies with double-hydrophilic block copolymers. 47,63 This effect might be useful for partitioning and separation of biomolecules.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

All-Aqueous Multi-phase Systems and Emulsions Formed via Low-Concentration Ultra-high-Molar Mass Polyacrylamides

2021

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Aqueous multi-phase systems have attracted a broad interest in recent years, which is mainly due to their applicability in biology for purification and isolation of biomolecules and also for separation of particles as well as environment for enzymatic reactions. Here, three polyacrylamides poly(N,N-dimethylacrylamide), poly(acrylamide), and poly(4-acryloylmorpholine) with ultrahigh molar mass were synthesized via photo-induced reversible addition−fragmentation chain-transfer polymerization (M n > 700,000 g•mol −1 ). The polymers were combined to form aqueous multi-phase systems with low total polymer concentration as low as 1.1 to 2.1 wt %. Furthermore, the aqueous multi-phase system could be transformed into water-in-water (w/w) emulsions, stabilized by layered double hydroxide nanoparticles. Due to the low polymer content, these aqueous multi-phase systems open up new pathways, for example, in the separation of biomolecules or the compartmentalization of aqueous environments in catalysis.

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Section: ■ Results and Discussionmentioning

confidence: 99%

All-Aqueous Multi-phase Systems and Emulsions Formed via Low-Concentration Ultra-high-Molar Mass Polyacrylamides

2021

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“…Nano‐sized delivery systems based on polysaccharide nanoparticles have been widely employed in carrying biomedical properties such as proteins, vaccines, genes, nucleic acids, polypeptides, and drugs in many fields of study and application ( Figure ). [ 41,42 ] The following sections cover the practical uses of polysaccharide nanoparticles in a variety of domains.…”

Section: Polysaccharide‐based Hybrid Materials For Bio and Non‐bio Se...mentioning

confidence: 99%

Polysaccharides‐Based Nano‐Hybrid Biomaterial Platforms for Tissue Engineering, Drug Delivery, and Food Packaging Applications

et al. 2022

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Polysaccharides have received immense interest in recent years for outstanding properties, including biocompatibility, biodegradability, renewable origin, and ease of modification. Owing to their considerable bioactivities, natural abundance, immunoactivity, and chemical modifiability in a variety of applications, they are considered potential biomaterials for the biomedical, biotechnological, and industrial sectors of the modern world. Polysaccharide‐based novel nanocomposites from starch, chitin and chitosan, alginates, cellulose, dextran, and hyaluronic acid with unique functional and structural attributes have been the subject of extensive study to promote their usage in a variety of fields, including biomedicine, food industry, and nonbiological sectors. Furthermore, polysaccharide‐based metal and nonmetal oxides, graphene, and carbon nanotubes have been used with various combinations in diverse fields of research. This review spotlights the application prospects of polysaccharides‐based hybrid nano‐biomaterials in tissue engineering, drug delivery, and food packaging concerning the biological and chemical properties, cross‐linking membranes, and focuses on the relationship between their composition and properties.

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“…3−5 Therefore, DHBCs may undergo reversible or irreversible changes in their physical properties or chemical structures, which particularly paves the way for the implementation of DHBC-based constructs in biomedicine. 6,7 Poly(acrylic acid) (PAA) is a pH-responsive polymer with a pK a value of 4.75. 8 Nanostructures bearing PAA moieties exhibit significant dimensional changes upon a change in pH due to deprotonation/protonation of carboxyl groups.…”

Section: ■ Introductionmentioning

confidence: 99%

Poly(acrylic acid)-b-Poly(vinylamine) Copolymer: Decoration with Silver Nanoparticles, Antibacterial Properties, Quorum Sensing Activity, and Cytotoxicity on Breast Cancer and Fibroblast Cell Lines

Ghaffarlou

Sütekin

Hammamchi

et al. 2022

ACS Appl. Polym. Mater.

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An elegant integration of primary amine-bearing segments into the acrylic acid-containing blocks and the subsequent addition of silver nanoparticles (Ag NPs) to this double hydrophilic block copolymer endowed the resulting well-defined self-assembled construct with promising antimicrobial and anti-quorum-sensing activity and high cytotoxicity against breast cancer cells. Poly(N-vinylformamide) (PNVF), precursor of amphoteric poly(vinyl amine) (PVAm), was chain-extended from pH-responsive poly(acrylic acid) (PAA) macro-chain-transfer agent synthesized via reversible addition–fragmentation chain transfer polymerization by the interchange of xanthates (RAFT/MADIX). PAA-b-PNVF block copolymers with molecular weights in the range of 12500–21800 Da and dispersities between 1.29 and 1.44 were characterized by FTIR, elemental analysis, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, and size exclusion chromatography (SEC). PAA-b-PVAm copolymer was obtained by hydrolysis of the PNVF block. The decoration of PAA-b-PVAm with monodisperse Ag NPs to yield AgNPs@PAA-b-PVAm proceeded through a simple and green approach by amine-induced reduction of Ag ions in aqueous media. The formation of AgNPs@PAA-b-PVAm was characterized by UV/vis spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and atomic force microscopy (AFM). AgNPs@PAA-b-PVAm displayed superior antimicrobial and anti-QS activity. The cell proliferation was tested with an MTT assay on L929 and MCF-7 cell lines. Both the AgNP-decorated and the bare copolymer showed significantly higher cytotoxicity on cancer cells compared to healthy ones.

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Aggregation and Crosslinking of Poly(N,N‐dimethylacrylamide)‐b‐pullulan Double Hydrophilic Block Copolymers

Cited by 5 publications

References 60 publications

All-Aqueous Multi-phase Systems and Emulsions Formed via Low-Concentration Ultra-high-Molar Mass Polyacrylamides

All-Aqueous Multi-phase Systems and Emulsions Formed via Low-Concentration Ultra-high-Molar Mass Polyacrylamides

Polysaccharides‐Based Nano‐Hybrid Biomaterial Platforms for Tissue Engineering, Drug Delivery, and Food Packaging Applications

Poly(acrylic acid)-b-Poly(vinylamine) Copolymer: Decoration with Silver Nanoparticles, Antibacterial Properties, Quorum Sensing Activity, and Cytotoxicity on Breast Cancer and Fibroblast Cell Lines

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