Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice

Xue, Xue; Yang, Jingyu; He, Yi; Wang, Lirong; Liu, Ping; Yu, Lisha; Bi, Guo‐Hua; Zhu, Mingming; Liu, Yueyang; Xiang, Rongwu; Yang, Xiaoting; Fan, Xinyu; Wang, Xiaomin; Jia, Qi; Zhang, Hongjie; Wei, Tuo; Cui, Wei; Ge, Guanglu; Xi, Zheng‐Xiong; Wu, Chunfu; Liang, Xing‐Jie

doi:10.1038/nnano.2016.23

Cited by 50 publications

(29 citation statements)

References 32 publications

(58 reference statements)

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“…Recently, a study reported that SWNTs (see Figure 1) could alleviate methamphetamine addiction by oxidized excessive dopamine [43]. In this study, aggregated form of SWNTs not only inhibited drug craving and relapse in mice, but also attenuated methamphetamine-induced conditioned place preference.…”

Section: Advances In the Therapeutic Effects Of Carbon Nanotubes On Msupporting

confidence: 52%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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Abstract:Nervous system diseases, such as Alzheimer's disease, stroke, and Parkinson's disease, are spreading around the world. These diseases involve complicatedly pathological processes, and so far, there are no effective medicines for therapy. Another type of psychiatric disorder is induced by drugs. The synthetic drugs, represented by methamphetamine, are becoming widely abuse. At present, the cure of methamphetamine dependence is mainly symptomatic treatment, but the recurrence rate is very high. As the common brain impairments in neuropsychiatric disease, it is necessary to summary novel strategies effectively restored brain function. In recent years, carbon nanotubes have attracted the attention due to their unique properties in the field of translational medicine. Recently, new advances reported that carbon nanotubes as a nanomedicine to treat various neuropsychiatric disorders. The purpose of this review is to introduce the therapeutic approaches and mechanisms of carbon nanotubes on neuropsychiatric disorders.

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Section: Advances In the Therapeutic Effects Of Carbon Nanotubes On Msupporting

confidence: 52%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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“…295,296 Carbon nanotubes have unique properties that make them a highly promising system for biomedical application, as they can be used to deliver therapeutic drugs and diagnostic agents into cells. 297,298 However, carbon nanotubes can also absorb light in the near-infrared region as photosensitizers and can kill cancer cells by localized photothermal effects. 299 …”

Section: Ruthenium(ii)-based Nanomaterials Systemsmentioning

confidence: 99%

The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

et al. 2017

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Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer drugs are organic molecules, while metallodrugs are very scarce. The advent of first metal based therapeutic agent, cisplatin, launched a new era in the application of transition metal complexes for therapeutic design. Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anti-cancer agents that serve as alternatives to cisplatin and its derivertives. The ruthenium(III) complexes have successfully been used in clinical research and their mechanisms of anticancer action have been reported in large volumes over the past few decades. Ruthenium(II) complexes have also attracted significant attention as anticancer candidates; however, only few of them have been reported comprehensively. In this review, we discuss the development of ruthenium(II) complexes as anticancer candidates and biocatalysts, including arene ruthenium complexes, polypyridyl ruthenium complexes, and ruthenium nanomaterial complexes. This review focuses on the likely mechanisms of action of ruthenium(II)-based anticancer drugs and the relationship between their chemical structures and biological properties. This review also highlights the catalytic activity and the photoinduced activation of ruthenium(II) complexes, their targeted delivery, and their activity in nanomaterial systems.

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“…Recently, evidences in the literature have shown a strong correlation between the nature of this complex multilayer of biomolecules (often called biomolecular corona) and the cellular uptake of nanoparticles in vitro and in vivo 5678910111213. In this respect a key role is played by the organization and mutual orientation of the molecules on the nanoparticle surface.…”

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confidence: 99%

In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

et al. 2016

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Nanoparticles interacting with, or derived from, living organisms are almost invariably coated in a variety of biomolecules presented in complex biological milieu, which produce a bio-interface or ‘biomolecular corona' conferring a biological identity to the particle. Biomolecules at the surface of the nanoparticle–biomolecule complex present molecular fragments that may be recognized by receptors of cells or biological barriers, potentially engaging with different biological pathways. Here we demonstrate that using intense fluorescent reporter binders, in this case antibodies bound to quantum dots, we can map out the availability of such recognition fragments, allowing for a rapid and meaningful biological characterization. The application in microfluidic flow, in small detection volumes, with appropriate thresholding of the detection allows the study of even complex nanoparticles in realistic biological milieu, with the emerging prospect of making direct connection to conditions of cell level and in vivo experiments.

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Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice

Cited by 50 publications

References 32 publications

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials

In situ characterization of nanoparticle biomolecular interactions in complex biological media by flow cytometry

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