Aggregate formation and surface activity property of an amphiphilic derivative of chitosan

Sui, Weiping; Song, Guilan; Chen, Guohua; Xu, Guiying

doi:10.1016/j.colsurfa.2004.09.019

Cited by 47 publications

(20 citation statements)

References 15 publications

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“…The surface tension measurements of chitosan and O-chitosan solutions at various concentrations were carried out on a Krss K12 Processor Tensionmeter with the plate method of Wilbelmy at 30 ±0.1 . All solutions were kept at room temperature for 1 d before surface tension measurement (Sui et al, 2005).…”

Section: Surface Tension Measurementmentioning

confidence: 99%

The aggregation behavior and formation of nanoparticles of oleoylchitosan in dilute aqueous solution

Chen

Sun

et al. 2008

J. Ocean Univ. China

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Oleoylchitosans (O-chitosans) with different degrees of substitution (DS) were synthesized by reacting chitosan with oleoyl chloride. The chemical structures of the products were characterized by 1 H NMR and FT-IR. These results suggested the formation of an amide linkage between the amino groups of chitosan and the carboxyl groups of oleic acid. The viscosity of O-chitosan sharply increased with the increase of concentration, whereas that of unmodified chitosan rose only slightly. This increase became larger as the DS increased. All of the O-chitosans could reduce surface tension slightly. The critical aggregation concentration (CAC) of O-chitosans with DS 5%, 11%, and 27% were 79.43 mgL -1 , 31.6 mgL -1 , and 10 mgL -1 , respectively. Nanoparticles were prepared using an O/W emulsification method. The mean diameters of the polymeric amphiphilic nanoparticles of O-chitosans with DS 5% and 11% were around 327.4 nm and 275.3 nm, respectively.

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Section: Surface Tension Measurementmentioning

confidence: 99%

The aggregation behavior and formation of nanoparticles of oleoylchitosan in dilute aqueous solution

Chen

Sun

et al. 2008

J. Ocean Univ. China

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“…[12][13][14] In our previous report, we synthesized a series of amphiphilic derivatives of carboxymethylchitosan (CMCHS) prepared by reaction of CMCHS with alkyl glycidol ether. [15,16] And their application properties such as surface activity, foaming property, emulsifying ability, and moisture retention have been studied. The aim of this work was to evaluate one of the hydrophobic modified derivative, (2-hydroxyl-3-butoxyl) propyl-carboxymethylchitosan (HBP-CMCHS), as potential drug carrier using Silymarin as an example.…”

Section: Introductionmentioning

confidence: 99%

“…Many kinds of soluble chitosan derivatives were prepared [1,13] , and some of them can form aggregates in solution, especially for the amphiphilic derivatives. [13][14][15][16] These micelles or nanoparticles can be used as peptide delivery system, gene delivery system, or drug delivery system. [12][13][14] In our previous report, we synthesized a series of amphiphilic derivatives of carboxymethylchitosan (CMCHS) prepared by reaction of CMCHS with alkyl glycidol ether.…”

Section: Introductionmentioning

confidence: 99%

Micellar Solubilization and In Vitro Release of Silymarin in the self‐Aggregates of an Amphiphilic Derivative of Chitosan

Sui

Yin

Kong

2010

Macromolecular Symposia

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Summary:The amphiphilic derivatives of chitosan, (2-hydroxyl-3-butoxyl)-propylcarboxymethyl-chitosan (HBP-CMCHS), can form micelles with the inner core of hydrophobic segments and the outer shell of hydrophilic segments. The typical poor water-soluble drug silymarin was solubilized in the HBP-CMCHS micellar by physical entrapped method. Results showed that the solubilizing capacity was enhanced by increasing the concentration of HBP-CMCHS with the same dosage of silymarin. Silymarin-loaded micellar system of HBP-CMCHS was characterized by TEM and DLS. TEM photograph revealed that the micelles were spherical and silymarin was solubilized in the cores of the spherical polymeric micelles. DLS showed that after solubilization the size of the micelles became bigger. In vitro tests showed that silymarin was slowly released from micellar solution and the release lasted up to 40 h by means of the dialysis method.

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“…Observe the transmission electron microscopy (TEM) observation at 75 kV with H-7000 (JEM-100CXII, Japan) in the micellar solution, which is negatively stained with 2% phosphotungstic acid and placed on a copper grid coated with film [9] .…”

Section: Characterization Of Acyclovir-loaded Micellarmentioning

confidence: 99%

Preparation of O’O-lauroyl Chitosan and Self-assembly Micellar Solubilization of Acyclovir

Tan¹

2017

dtetr

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Aggregate formation and surface activity property of an amphiphilic derivative of chitosan

Cited by 47 publications

References 15 publications

The aggregation behavior and formation of nanoparticles of oleoylchitosan in dilute aqueous solution

The aggregation behavior and formation of nanoparticles of oleoylchitosan in dilute aqueous solution

Micellar Solubilization and In Vitro Release of Silymarin in the self‐Aggregates of an Amphiphilic Derivative of Chitosan

Preparation of O’O-lauroyl Chitosan and Self-assembly Micellar Solubilization of Acyclovir

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