Aggregate consumer exposure to UV filter ethylhexyl methoxycinnamate via personal care products

Ultraviolet filter contact and photocontact allergy: consumer exposure and risk assessment for octocrylene from personal care products and sunscreens

“…Aggregate exposure is not commonly incorporated into QRA studies and it was included for the first time in a recent QRA case study performed by the Dutch National Institute of Public Health and the Environment . Furthermore, our approach of using individual‐level data for exposure estimation including data on specific PCPs used by respondents is well suited for substances not present in all PCPs of a given category, such as OCT, to avoid overestimation of exposure …”

“…Additionally, PCP use patterns in other countries can differ and thus result in different exposures. Limitations of the probabilistic modelling methodology at an individual level have been discussed by Manová et al . (see also Supplementary Methods S1).…”

Nanoparticles and nanofibers for topical drug delivery

“…Octyl methoxycinnamate ( OMC ), also called ethylhexyl methoxycinnamate , is used as an active ingredient in sunscreens [118]. Puglia et al [119] incorporated two components, OMC and diethyltoluamide, into SLNs and used differential scanning calorimetry to determine the percutaneous absorption.…”

Cyanobacterial metabolites as a source of sunscreens and moisturizers: a comparison with current synthetic compounds

“…EHMC has been the subject of significant debate regarding its accumulation in human tissue, and possible risks associated with potential endocrine-disrupting effects (Manová et al, 2015). Investigations on rats into the effects of exposure to high concentrations of EHMC showed a marked decrease in the levels of thyroid hormones, which could affect both reproductive and neurological development (Axelstad et al, 2011;Klammer et al, 2007).…”

“…In order to better protect against UV radiation, consumers demand PCPs with a high sun protection factor (SPF), and therefore are exposed to significantly larger amounts and also a wider variety of UV filters (Manová et al, 2013). The estimated worldwide production of UV filters is about 10 000 metric tonnes per year requiring high production volumes (Manová et al, 2015). The most important aspect of the development of a new UV filter is safety: a sunscreen must be heat-and photo-stable, non-irritant, non-sensitizing and non-phototoxic.…”