Aggravated toxicity of copper sulfide nanoparticles <i>via</i> hypochlorite-induced nanoparticle dissolution

Kong, Long; Wang, Xiaohong; Li, Xiaoyü; Liu, Jian; Che, Xin; Qin, Yingju; Huang, Xinxin; Zhou, Hongyu; Martyniuk, Christopher J.; Yan, Bing

doi:10.1039/d1en01203g

Cited by 6 publications

(2 citation statements)

References 66 publications

(79 reference statements)

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“…However, the use of hypochlorite, a common disinfectant in wastewater treatment, may increase the potential risks of toxicity to aquatic life and human health by promoting the dissolution of CuS NPs in water. A recent study has shed light on the impact of hypochlorite disinfection on the chemical stability of CuS NPs and the exacerbated toxicity of CuS NPs resulting from the dissolution induced by hypochlorite [117]. The results revealed that hypochlorite oxidation compromised the chemical stability of CuS NPs and heightened the bioavailability of dissolved copper in zebrafish embryos.…”

Section: Copper Sulfide Nanoparticlesmentioning

confidence: 99%

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

Mutalik,

Nivedita,

Sneka

et al. 2024

IJMS

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Nanomaterials are widely used in various fields, and ongoing research is focused on developing safe and sustainable nanomaterials. Using zebrafish as a model organism for studying the potentially toxic effects of nanomaterials highlights the importance of developing safe and sustainable nanomaterials. Studies conducted on nanomaterials and their toxicity and potential risks to human and environmental health are vital in biomedical sciences. In the present review, we discuss the potential toxicity of nanomaterials (inorganic and organic) and exposure risks based on size, shape, and concentration. The review further explores various types of nanomaterials and their impacts on zebrafish at different levels, indicating that exposure to nanomaterials can lead to developmental defects, changes in gene expressions, and various toxicities. The review also covers the importance of considering natural organic matter and chorion membranes in standardized nanotoxicity testing. While some nanomaterials are biologically compatible, metal and semiconductor nanomaterials that enter the water environment can increase toxicity to aquatic creatures and can potentially accumulate in the human body. Further investigations are necessary to assess the safety of nanomaterials and their impacts on the environment and human health.

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Section: Copper Sulfide Nanoparticlesmentioning

confidence: 99%

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

Mutalik,

Nivedita,

Sneka

et al. 2024

IJMS

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show abstract

“…These suggested that partial sulfidation might decrease the dissolution of Cu oxide NPs in the extracellular medium. Moreover, the cellular acidic environment and free radicals could accelerate the dissolution of metal sulfide . In the biological system, a few studies reported that CuS could undergo degradation under both in vivo and in vitro conditions. , Recently, Curcio et al found that CuS was quickly dismantled into smaller units in the cells.…”

Section: Introductionmentioning

confidence: 99%

Cu(I)/Cu(II) Released by Cu Nanoparticles Revealed Differential Cellular Toxicity Related to Mitochondrial Dysfunction

Wang

2023

Environ. Sci. Technol.

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Cu-based nanoparticles (NPs) have been increasingly fabricated, and different Cu species (i.e., Cu+ and Cu2+) of these NPs are tuned to achieve differential physicochemical properties. Although ion release is one of the major toxic mechanisms of Cu-based NPs, differences in cytotoxicity between released Cu(I) and Cu(II) ions are largely unknown. In this study, the A549 cells exhibited a lower tolerance to Cu(I) compared with Cu(II) accumulation. Bioimaging of labile Cu(I) indicated that the change of the Cu(I) level upon CuO and Cu2O exposure displayed different trends. We then developed a novel method to selectively release Cu(I) and Cu(II) ions within the cells by designing Cu x S shells for Cu2O and CuO NPs, respectively. This method confirmed that Cu(I) and Cu(II) exhibited different cytotoxicity mechanisms. Specifically, excess Cu(I) induced cell death through mitochondrial fragmentation, which further led to apoptosis, whereas Cu(II) resulted in cell cycle arrest at the S phase and induced reactive oxygen species generation. Cu(II) also led to mitochondrial fusion, which was likely due to the influence of the cell cycle. Our study first uncovered the difference between the cytotoxicity mechanisms of Cu(I) and Cu(II), which could be greatly beneficial for the green fabrication of engineered Cu-based NPs.

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A systematic overview of metal nanoparticles as alternative disinfectants for emerging SARS-CoV-2 variants

Soni,

Marya,

Sharma

et al. 2024

Arch Microbiol

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Aggravated toxicity of copper sulfide nanoparticles via hypochlorite-induced nanoparticle dissolution

Abstract: Sulfidation has been considered as a primary detoxification process for metal and metal oxide nanoparticles (NPs). Copper sulfide nanoparticles (CuSNPs) are deemed relatively non-toxic to aquatic wildlife due to their...

Cited by 6 publications

References 66 publications

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

Cu(I)/Cu(II) Released by Cu Nanoparticles Revealed Differential Cellular Toxicity Related to Mitochondrial Dysfunction

A systematic overview of metal nanoparticles as alternative disinfectants for emerging SARS-CoV-2 variants

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