Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation

Liu, Peng; Li, Heng; Xu, Hongyu; Gong, Jinsong; Jiang, Min; Xu, Zhenghong; Shi, Jinsong

doi:10.1016/j.isci.2023.107754

iScience

2023

DOI: 10.1016/j.isci.2023.107754

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Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation

Peng Liu,

Heng Li,

Hongyu Xu

et al.

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2024

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Cited by 3 publications

References 62 publications

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Differential protein expression and metabolite profiling in glaucoma: Insights from a multi‐omics analysis

Mok,

Park,

Han

2024

BioFactors

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Various substances within the aqueous humor (AH) can directly or indirectly impact intraocular tissues associated with intraocular pressure (IOP), a critical factor in glaucoma development. This study aims to investigate individual changes in these AH substances and the interactions among altered components through a multi‐omics approach. LC/MS analysis was conducted on AH samples from patients with exfoliation syndrome (XFS, n = 5), exfoliation glaucoma (XFG, n = 4), primary open‐angle glaucoma (POAG, n = 11), and cataracts (control group, n = 7). Subsequently, differentially expressed proteins and metabolites among groups, alterations in their network interactions, and their biological functions were examined. Both data‐independent acquisition and data‐dependent acquisition methods were employed to analyze the AH proteome and metabolome, and the results were integrated for a comprehensive analysis. In the proteomics analysis, proteins upregulated in both the XFG and POAG groups were associated with lipid metabolism, complement activation, and extracellular matrix regulation. Metabolomic analysis highlighted significant changes in amino acids related to antioxidant processes in the glaucoma groups. Notably, VTN, APOA1, C6, and L‐phenylalanine exhibited significant alterations in the glaucoma groups. Integration of individual omics analyses demonstrated that substances associated with inflammation and lipid metabolism, altered in the glaucoma groups, showed robust interactions within a complex network involving PLG, APOA1, and L‐phenylalanine or C3, APOD, and L‐valine. These findings offer valuable insights into the molecular mechanisms governing IOP regulation and may contribute to the development of new biomarkers for managing glaucoma.

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Differential protein expression and metabolite profiling in glaucoma: Insights from a multi‐omics analysis

Mok,

Park,

Han

2024

BioFactors

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The preparation, modification and hepatoprotective activity of chitooligosaccharides: A review

Liu,

Chen,

et al. 2024

International Journal of Biological Macromolecules

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Electrochemical Sensing of Phenylalanine using Polyaniline-Based Molecularly Imprinted Polymers

Sarangi,

Srivastava,

Gogoi-Tiwari

et al. 2024

J. Phys. Chem. B

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Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation

Cited by 3 publications

References 62 publications

Differential protein expression and metabolite profiling in glaucoma: Insights from a multi‐omics analysis

Differential protein expression and metabolite profiling in glaucoma: Insights from a multi‐omics analysis

The preparation, modification and hepatoprotective activity of chitooligosaccharides: A review

Electrochemical Sensing of Phenylalanine using Polyaniline-Based Molecularly Imprinted Polymers

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