Agglutination Tube Racks for use with the Microscope*

Relationship and probability in mendelian populations

“…This s u g g e s t s t h a t c o r r e c t i o n f o r t h e underestimated s t a n d a r d e r r o r s could be made by a s s i g n i n g reduced weights (weight w , 0 < w < 1 ) t o each gene o r i n d i v i d u a l i n a r e l a t e d group, t h e weights being independent of observed phenotype f r e q u e n c i e s b u t f i x e d solel y by t h e mode of r e l a t i o n s h i p p r e s e n t e d . This " d i r e c t weight i n g method" w a s i n v e s t i g a t e d (Cotterman, 1947) Here t h e genotype-phenotype r e l a t i o n s u s u a l l y defy adequate d e s c r i p t i o n i n terms of "dominance ,'I and gene frequency e s t i m a t i o n may be e x c e e d i n g l y complex even f o r samples of u n r e l a t e d i n d i v i d u a l s . T h i s methodological gap seems p a r t i c ul a r l y u n f o r t u n a t e inasmuch a s t h e r e are p r o b a b l y no genes i n any organism whose f r e q u e n c i e s have been more e x t e n s i v e l y i n v e s t i g a t e d .…”

“…6 , p u t t i n g k, = r -k 2 and q / ( l + q ) = c. Cotterman (1947) , and Finney (1948). But we w i l l develop a g e n e r a l formula r e g a r d i n g gene frequency information t h a t has not p r e v i o u s l y been p r e s e n t e d and which i l l u s t r a t e s one f u r t h e r a p p l i c a t i o n of t h e phylotype and genotype p a i r proba b i l i t i e s of s e c t i o n s 4 and 7.…”