Agglomeration behavior of lipid-capped gold nanoparticles

Ranjan, Rajeev; Kirillova, Maria A.; Esimbekova, Elena N.; Жарков, С. М.; Kratasyuk, Valentina A.

doi:10.1007/s11051-018-4215-5

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…A vial of the lyophilized preparation contained 0.5 mg bacterial luciferase (EC Four different types of AuNPs (AuNP1, AuNP2, AuNP3 and AuNP4) were prepared using the method described previously (Abhijith et al, 2014;Ranjan et al, 2018)…”

Section: Methodsmentioning

confidence: 99%

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Ethylene Diamine Functionalized Citrate-Capped Gold Nanoparticles for Metal-Enhanced Bioluminescence

Ranjan

Kirillova

Kratasyuk

2020

Journal of Siberian Federal University. Biology

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Metal-enhanced bioluminescence (MEB) is a complex photophysical event which manifests itself in manifold luminescence enhancement and depends on many parameters. The parameters include the distance between the luminescent source and the nanomaterial surface, the size and shape of nanoparticles, localized surface plasmon resonance (LSPR) peaks of the nanomaterial and the dielectric constant of the surrounding medium. Studying distance-dependent MEB in the presence of linkers of specified length may provide new insights into luminescence enhancement. In this regard, the present investigation is aimed to understand the role of ethylene diamine as a potential linker in model systems for distance-dependent metal-enhanced bioluminescence (MEB) with gold nanoparticles (AuNPs). Four different types of AuNPs (AuNP1, AuNP2, AuNP3, AuNP4) were synthesized by varying the trisodium citrate (TC) and silver nitrate (AgNO3) concentrations with maximum absorbance values of 0.99, 1.24, 1.21 and 1.38 respectively and the corresponding LSPR peaks (λmax) of 520 nm, 535 nm, 525 nm, and 525 nm. Luminescence enhancement up to 1.44-fold was observed when ethylene diamine (ED) was used as a linker in the presence of 1-N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC), ATP and AuNP1. The sample consisting of FMN, EDC and AuNP1 showed 1.3-fold luminescence enhancement. It was noted that AuNPs synthesized using AgNO3 as an additional component did not enhance luminescence in all the investigations. The suggested technique of using linkers of predetermined lengths may also prove fairly effective for studying other parameters which can influence MEB and cause sensitivity enhancement of luminescence-based biosensors

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Section: Methodsmentioning

confidence: 99%

“…AuNPs aggregation can be visually observed. It takes less than a minute to observe color change from red to blue or purple in case the agglomeration of AuNPs occurs (Ranjan et al, 2018). The stability of AuNPs depends upon the capping agent.…”

Section: Effect Of Edc and Ed On Aunps Stabilitymentioning

confidence: 99%

Ethylene Diamine Functionalized Citrate-Capped Gold Nanoparticles for Metal-Enhanced Bioluminescence

Ranjan

Kirillova

Kratasyuk

2020

Journal of Siberian Federal University. Biology

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“…These results were obtained as part of the optimization process to identify the lowest concentration of NaCl required to induce agglomeration in both the aptamer-functionalized (ssDNA-PEI-Au-PS) and nonfunctionalized labels (PEI-Au-PS). The layered particles showed a two-fold improvement in ionic strength stability when compared with traditional citrate-reduced AuNPs. , For all subsequent experiments, the label particles were stabilized in a solution of NaCl (75 mM) before immobilization on the testing zones of the microfluidic device.…”

Section: Resultsmentioning

confidence: 99%

“…The layered particles showed a two-fold improvement in ionic strength stability when compared with traditional citratereduced AuNPs. 48,49 For all subsequent experiments, the label particles were stabilized in a solution of NaCl (75 mM) before immobilization on the testing zones of the microfluidic device.…”

Section: Resultsmentioning

confidence: 99%

Ionic Strength Influences on Biofunctional Au-Decorated Microparticles for Enhanced Performance in Multiplexed Colorimetric Sensors

Díaz‐Amaya

Zhao

Allebach

et al. 2020

ACS Appl. Mater. Interfaces

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The rising development of biosensors offers a great potential for health, food, and environmental monitoring. However, in many colorimetric platforms, there is a performance limitation stemming from the tendency of traditional Au nanoparticles toward nonspecific aggregation in response to changing ionic strength (salt concentration). This work puts forward a new type of colorimetric aptamer-functionalized labeling of microparticles, which allows to leverage an increase in ionic strength as a positive driver of enhanced detection performance of analytical targets. The resulting device is a cost-effective, instrument-free, portable, and reliable aptasensor that serves as basis for the fabrication of universal paper-based colorimetric platforms with the capability of multiplex, multireplicates and provides quantitative colorimetric detection. A controlled fabrication process was demonstrated by keeping 90% of the signal obtained from the as-fabricated devices (n = 40) within ± 1 standard deviation (SD) (relative SD = 5.69%) and following a mesokurtic normal-like distribution (p = 0.385). We propose for the first time a salt-induced aggregation mechanism for highly stable multilayered label particles (ssDNA-PEI-Au-PS) as the basis of the detection scheme. The use of DNA aptamers as capture biomolecules and PEI as an encapsulating agent allows for a sensitive and highly specific colorimetric response. As a proof of concept, multiplexed detection of mercury (Hg 2+ ) and arsenic (As 3+ ) was demonstrated. In addition, we introduced a robust image analysis algorithm for testing zone segmentation and color signal quantification that allowed for analytical detection, reaching a limit of detection of 1 ppm for both targeted analytes, with enough evidence (p > 0.05) to prove the high specificity of the fabricated device versus a pool of possible interferent ions.

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“…The maintenance of peak positions of AuNPs during incubations indicated extra stability of S‐AuNPs as stated elsewhere (Leonard, Ahmmad, Okamura, & Kurawaki, ). In the study of Ranjan et al, aggregation tendency of AuNPs synthesized using either trisodium citrate or silver nitrate was investigated in aqueous sodium chloride solutions of varying concentrations after capping AuNPs with lipid mixtures (Ranjan, Kirillova, Esimbekova, Zharkov, & Kratasyuk, ). Their findings were akin to ours in such a way that capped AuNPs could withstand the aggregation at all salt levels.…”

Section: Discussionmentioning

confidence: 99%

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

Aktürk

Gök

Erdemli

et al. 2019

J Biomedical Materials Res

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Herein, an easy one‐pot synthesis method for gold nanoparticles (AuNPs), involving only gold salt and sericin extracted from silkworm cocoon in the presence of ultraviolet C (UVC) radiation, was developed. Nanoparticle formation was confirmed by characteristic surface plasmon resonance peaks at 520–540 nm wavelengths, and the influence of silk sericin on enhancing the colloidal stability of AuNPs was confirmed. Transmission electron microscopy examination showed the average size (<10 nm) and size distribution decreased significantly with higher sericin concentration. No antibacterial activity was observed on Gram‐positive Bacillus subtilis or Gram‐negative Escherichia coli for sole AuNPs (0.065–0.26 mg/ml), but the conjugation of AuNPs with streptomycin antibiotic decreased significantly the required minimum inhibitory concentration doses, as also confirmed with agar plating, Scanning Electron Microscopy and Atomic Force Microscopy analyses. Furthermore, sericin‐capped AuNPs showed high cell viabilities (>100%) and no sign of any detectable apoptosis or necrosis in 1‐day incubation. Also, high real‐time cell proliferation results of AuNPs competitive with positive control groups implied excellent in vitro biocompatibility. These results evidenced that sericin enhanced the colloidal stability of AuNPs and the biological activities of sericin‐capped AuNPs reported here could render them suitable nanoscale vehicles for biomedical applications.

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Agglomeration behavior of lipid-capped gold nanoparticles

Cited by 4 publications

References 32 publications

Ethylene Diamine Functionalized Citrate-Capped Gold Nanoparticles for Metal-Enhanced Bioluminescence

Ethylene Diamine Functionalized Citrate-Capped Gold Nanoparticles for Metal-Enhanced Bioluminescence

Ionic Strength Influences on Biofunctional Au-Decorated Microparticles for Enhanced Performance in Multiplexed Colorimetric Sensors

One‐pot facile synthesis of silk sericin‐capped gold nanoparticles by UVC radiation: Investigation of stability, biocompatibility, and antibacterial activity

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