An experimental study was performed to investigate the effects of spouting gas velocity, fluidizing gas velocity, sound wave frequency and sound wave pressure level on fluidization behaviors of ultrafine particles in an acoustic spout-fluid bed with a draft tube. A half-cylinder with a diameter of 120 mm and height of 1200 mm was used as the fluidization column, TiO2ultrafine particles with an average diameter of 290 nm were employed as the bed materials while the high-speed atmosphere jet was utilized as the spouting gas. Results showed that high-speed jet as spouting gas could effectively disrupt the agglomerates of TiO2ultrafine particles and reduce the agglomerate size significantly. The introduced fluidized gas in annulus was conducive to eliminate dead-zone in the bottom of bed. Sound wave could break bubbles, restrain channeling making the axial fluidization state in annular region to be more uniform and homogeneous, thus significantly improved the fluidization quality of agglomerates in the annulus, reduced the minimum spouting velocity of particles, and promoted the stable circulation of inner particles in spout-fluid bed with a draft tube.