AGES effect on the biomechanics of the knee tendon

Adouni, Malek; Gouissem, Afif; Khatib, Fadi Al; Mbarki, Raouf

doi:10.1016/j.rineng.2023.101155

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…All MD simulations were performed using LAMMPS molecular dynamics software [ 36 ] ( Fig 1 ). Additional details about the developed model can be found in the S1 File and our prior works [ 18 , 24 , 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

Knee joint biomechanics and cartilage damage prediction during landing: A hybrid MD-FE-musculoskeletal modeling

et al. 2023

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Understanding the mechanics behind knee joint injuries and providing appropriate treatment is crucial for improving physical function, quality of life, and employability. In this study, we used a hybrid molecular dynamics-finite element-musculoskeletal model to determine the level of loads the knee can withstand when landing from different heights (20, 40, 60 cm), including the height at which cartilage damage occurs. The model was driven by kinematics–kinetics data of asymptomatic subjects at the peak loading instance of drop landing. Our analysis revealed that as landing height increased, the forces on the knee joint also increased, particularly in the vastus muscles and medial gastrocnemius. The patellar tendon experienced more stress than other ligaments, and the medial plateau supported most of the tibial cartilage contact forces and stresses. The load was mostly transmitted through cartilage-cartilage interaction and increased with landing height. The critical height of 126 cm, at which cartilage damage was initiated, was determined by extrapolating the collected data using an iterative approach. Damage initiation and propagation were mainly located in the superficial layers of the tibiofemoral and patellofemoral cartilage. Finally, this study provides valuable insights into the mechanisms of landing-associated cartilage damage and could help limit joint injuries and improve training programs.

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Section: Methodsmentioning

confidence: 99%

Knee joint biomechanics and cartilage damage prediction during landing: A hybrid MD-FE-musculoskeletal modeling

et al. 2023

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“…As an essential structural component within the knee joint, the ACL determines the function and longevity of the entire knee structure. Previous studies have focused primarily on the mechanical properties of the ACL as an important stabilizer for knee joint motion [24] . KOA induced by ACL degeneration is believed to be caused by an imbalance in knee mechanics, which accelerates local cartilage wear and tear, thereby leading to an earlier onset of OA [25] .…”

Section: Discussionmentioning

confidence: 99%

Identification of anterior cruciate ligament fibroblasts and their contribution for knee osteoarthritis progression by single-cell analyses

Zhang

et al. 2023

Preprint

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Objective A better Understanding of the key regulatory cells in the anterior cruciate ligament (ACL), and their role and regulatory mechanisms in knee osteoarthritis (KOA) progression can facilitate the development of targeted treatment strategies for KOA. Methods The relationship between ACL degeneration and KOA was first explored using human ACL specimens and mouse models. Next, single-cell RNA sequencing (scRNA-seq) and single-cell detection of transposase accessible and chromatin sequencing (scATAC-seq) data were integrated to reveal the transcriptional and epigenomic landscape of ACL in normal and osteoarthritis (OA) states. Results Six cell populations were identified in the human ACL, among which were inflammation-associated fibroblasts (IAFs). Degeneration of the ACL during OA mechanically alters the knee joint homeostasis and influences the microenvironment by regulating inflammatory- and osteogenic-related factors, thereby contributing to the progression of KOA. Specifically, a IAF subpopulation identified in OA ACL was found to enhance the transcription and secretion of EGER via SOX5 upregulation, with consequent activation of the EGER–EGFR signaling pathway. These molecular events led to the upregulation of downstream inflammatory and osteogenic factors, and the downregulation of the extracellular matrix-associated factor, thereby leading to knee osteoid formation, cartilage degeneration, and OA progression. Conclusions In summary, this study identifies a novel subpopulation of fibroblasts in the ACL, which confirms the importance of the ACL in knee joint homeostasis and disease. Additionally, the specific mechanism by which these IAFs regulate KOA progression was uncovered, which provides new foundation for the development of targeted treatments for KOA.

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“…The subject-specific Musculoskeletal-FE model (Fig. 1 ) was created by scaling a previously developed and validated model 51 , 60 – 63 using data extracted from the OpenSim model and X-ray measurements. In this model, the hip and ankle joints were represented as three-dimensional and two-dimensional spherical joints, respectively.…”

Section: Methodsmentioning

confidence: 99%

The effect of body weight on the knee joint biomechanics based on subject-specific finite element-musculoskeletal approach

Adouni,

Aydelik,

Faisal

et al. 2024

Sci Rep

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Knee osteoarthritis (OA) and obesity are major public health concerns that are closely intertwined. This intimate relationship was documented by considering obesity as the most significant preventable risk factor associated with knee OA. To date, however, the effects of obesity on the knee joint's passive-active structure and cartilage loading have been inconclusive. Hence, this study investigates the intricate relationship between obesity and knee OA, centering on the biomechanical changes in knee joint active and passive reactions during the stance phase of gait. Using a subject-specific musculoskeletal and finite element approach, muscle forces, ligament stresses, and articular cartilage contact stresses were analyzed among 60 individuals with different body mass indices (BMI) classified under healthy weight, overweight, and obese categories. Our predicted results showed that obesity significantly influenced knee joint mechanical reaction, increasing muscle activations, ligament loading, and articular cartilage contact stresses, particularly during key instances of the gait cycle—first and second peak loading instances. The study underscores the critical role of excessive body weight in exacerbating knee joint stress distribution and cartilage damage. Hence, the insights gained provide a valuable biomechanical perspective on the interaction between body weight and knee joint health, offering a clinical utility in assessing the risks associated with obesity and knee OA.

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AGES effect on the biomechanics of the knee tendon

Cited by 4 publications

References 40 publications

Knee joint biomechanics and cartilage damage prediction during landing: A hybrid MD-FE-musculoskeletal modeling

Knee joint biomechanics and cartilage damage prediction during landing: A hybrid MD-FE-musculoskeletal modeling

Identification of anterior cruciate ligament fibroblasts and their contribution for knee osteoarthritis progression by single-cell analyses

The effect of body weight on the knee joint biomechanics based on subject-specific finite element-musculoskeletal approach

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