2024
DOI: 10.1101/2024.07.03.601920
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Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy

Yixuan Wang,
Daniel R. Bergman,
Erica Trujillo
et al.

Abstract: Since the introduction of the first immune checkpoint inhibitor (ICI), immunotherapy has changed the landscape of molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and for all patients. There has been a growing interest in using mathematical and computational models to optimize clinical responses. Ordinary differential equations (ODEs) have been widely used for mechanistic modeling in immuno-oncology and immunotherapy because they allow rapid simulations of temporal chan… Show more

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