Agent-Based Computational Modeling of Wounded Epithelial Cell Monolayers

Abstract

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A virtual look at Epstein–Barr virus infection: Simulation mechanism

“…Indeed, a C-ImmSim model captures important elements of EBV infection [46]. Other studies using agent-based simulation to address the course of specific diseases include [47][48][49][50][51][52][53][54].…”

The role of laser fluence in cell viability, proliferation, and membrane integrity of wounded human skin fibroblasts following helium‐neon laser irradiation

“…The central scratch has been used with multiple cell types and, as the monolayers heal the wound in a characteristic manner, they have been used to study cell polarization, matrix remodeling, cell migration, and numerous other processes [12]. Kornyei et al (2000) [14] used an in vitro scratch-wound model to investigate astroglial responses to mechanical injury while Saga et al (2003) [15], Liang et al (2004) [16], Farooqui et al (2004) [17], and Walker et al (2004) [18] used the cell scratch-wound model to study the proliferative and migratory responses of different cells. Lau et al (2001) [19] focused on the production of four inflammatory cytokines in primary culture using an injury model which simulated in vivo mechanical trauma and reported that all four cytokines began to increase 1 hour post-scratch and remained at high levels throughout the experiment [19].…”

Multi-scale interaction of particulate flow and the artery wall

“…ABMs have been successfully applied to problems similar to that discussed here, which are defined in figure 5 (57,58). It is appropriate to conclude this section by highlighting one final advantage of our multi-scale methodology.…”