Agenesis of the Inferior Vena Cava

Gensas, Caroline Saltz; Pires, Leonardo Martins; Kruse, Marcelo Lapa; Leiria, Tiago Luiz Luz; Gomes, Daniel Garcia; Lima, Gustavo Glotz de

doi:10.1016/s2214-1235(15)30090-9

Cited by 4 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 8 Thrombosis is often diagnoses incidentally during abdominal imaging, abdominal surgery, or failed catheterization. 9 In our cohort, we observed that the diagnosis of IVCA is frequently made after the occurrence of proximal DVT at a young age. Indeed, up to 5% of patients under 30 years of age with unprovoked proximal DVT have an IVCA.…”

Section: Discussionmentioning

confidence: 74%

Direct Oral Anticoagulants for Inferior Vena Cava Agenesis

Iarossi,

Hermans

2023

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Deep vein thrombosis (DVT) is common in the general population, with an annual incidence of 1 to 2 per 1000 people. Inferior vena cava agenesis (IVCA) increased the risk of developing DVT and is found in approximately 5% of young adults (20-40-year-olds) diagnosed with unprovoked proximal DVT. IVCA can be caused by a defective embryological process, or be a result of intrauterine or perinatal thrombosis. Its estimated incidence in the general population ranges from 0.0005% to 1%, usually involving a partial absence of one of the four segments of the inferior vena cava (IVC). The management during the extended phase of patients with DVT associated with IVCA is not yet harmonized, as it is poorly described in the literature. Patients with IVCA are considered to be at high risk of DVT occurrence, prompting physicians to continue extended anticoagulation, often using vitamin K antagonists. In this retrospective study, we present a cohort of 11 patients diagnosed with IVCA following a DVT, who subsequently received extended treatment with a direct oral anticoagulants. These findings offer reassuring insights into the extended utilization of direct oral anticoagulants, demonstrating both antithrombotic efficacy and a favorable safety profile.

show abstract

Section: Discussionmentioning

confidence: 74%

Direct Oral Anticoagulants for Inferior Vena Cava Agenesis

Iarossi,

Hermans

2023

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…The latter is divided based on location into intrahepatic, suprarenal, renal, and infrarenal segment agenesis. Only 6% of all cases are renal or infrarenal variants [1] , [2] , [3] , 5 , 7] . Some authors suggest that agenesis of the infrarenal IVC segment develops because of intrauterine thrombosis rather than a congenital malformation, but there is still no clear evidence for either theory [2] , [3] , [4] , 8 , 9] .…”

Section: Discussionmentioning

confidence: 99%

“…Its embryonic development is complex and consists of several interconnected phases between the sixth and eighth gestational weeks: formation, regression, and anastomosis of 4 pairs of veins (supracardinal and subcardinal veins, posterior cardinal vein, and vitelline [omphalomesenteric] veins). Understandably, many different malformations can occur, such as duplication, malposition, or agenesis, most of which have no clinical significance [1] , [2] , [3] , [4] . Their incidence in the general population ranges from 0.05% to 8.7% [5] .…”

Section: Introductionmentioning

confidence: 99%

Infrarenal inferior vena cava agenesis presenting as acute abdomen and hydronephrosis – case report

Brkić

Želalić

Zekan-Vučetić

et al. 2023

Radiology Case Reports

View full text Add to dashboard Cite

“…The exuberance of collateral circulation prompted further image studies, with the diagnosis of inferior vena cava agenesis [1,2]. Although considered a rare condition, the number of diagnosed cases is increasing, and it is thought that this condition may be underdiagnosed, mainly because most patients are asymptomatic [3].…”

Section: Discussionmentioning

confidence: 99%

Inferior vena cava agenesis with exuberant collateral circulation

Cristino¹,

Silva²,

Pais³

et al. 2017

IJCRI

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. IJCRI publishes CASE REPORTWe present a case of 55-year-old female with a history of past alcohol consumption (75 g/day for ten years), with no other relevant medical history, who was referred to our hepatology unit. She presented with leukopenia and thrombocytopenia, normal mean corpuscular volume, mildly elevated total bilirubin (1.8 mg/dL), alkaline phosphatase (192 U/L) and gamma-glutamyl transferase (127 U/L), with normal aminotransferases, albumin and coagulation. Physical examination revealed exuberant collateral circulation of the abdominal wall (Figure 1). The esophagoduodenoscopy revealed grade III esophageal varices, and the abdominal ultrasonography showed hypertrophy of the caudate lobe and heterogeneous echotexture, and splenomegaly with collateral circulation of the splenic hilum. The autoimmune study, hepatitis serologies and iron studies were normal, and the transient elastography was 48 Kpa, consistent with liver cirrhosis. A computed tomography (CT) scan of the abdomen (Figure 2A) revealed exuberant retrocrural collateral circulation, with varices in the azygos and hemiazygos systems, hepatorenal and splenorenal spaces, with lack of permeability in the inferior vena cava, between the renal and the suprahepatic veins. The magnetic resonance angiography ( Figure 2B) confirmed inferior vena cava agenesis.Due to beta-blocker intolerance, the esophageal varices were obliterated with endoscopic variceal ligation. She remains in follow-up after three years.

show abstract

Agenesis of the Inferior Vena Cava

Cited by 4 publications

References 8 publications

Direct Oral Anticoagulants for Inferior Vena Cava Agenesis

Direct Oral Anticoagulants for Inferior Vena Cava Agenesis

Infrarenal inferior vena cava agenesis presenting as acute abdomen and hydronephrosis – case report

Inferior vena cava agenesis with exuberant collateral circulation

Contact Info

Product

Resources

About