Agency for Toxic Substances and Disease Registry's Toxicological Profiles: Contribution to Public Health

DeRosa, Chris

doi:10.1177/074823379401000301

Cited by 11 publications

(3 citation statements)

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“…The increase of the Pb levels in the environment is mainly caused by its excessive use in industrial processes, such as welding and smelting [1,2]. However, excessive exposure to it could cause a variety of toxic effects, among which is its adverse influence on the kidney.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zhang

Gao

Guo

et al. 2016

Biol Trace Elem Res

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Lead (Pb) exposure is a global environmental problem that can deplete body antioxidant enzymes, causing damage to various macromolecules and ultimately cell death. Pb exposure could lead to serious renal damage. Baicalin, a traditional Chinese medicine, could protect against renal injury through inhibition of oxidative stress and apoptosis. This study was designed to investigate the protective efficacy of baicalin against Pb-induced nephrotoxicity in mice and to elucidate the potential mechanisms using animal experiment. The results revealed that baicalin decreased Pb-induced bodyweight loss, declined kidney coefficients, and ameliorated renal function and structure in a dose-dependent manner. Meanwhile, baicalin dose dependently increased Pb-induced activity of SOD and GSH-Px, while the content of MDA in the kidney was decreased. In addition, baicalin enhanced the Bcl-2/Bax ratio associated with apoptosis in the kidney. These data indicated that further investigation of the use of baicalin as a new natural chemopreventive agent against Pd poisoning is warranted.

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Section: Introductionmentioning

confidence: 99%

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zhang

Gao

Guo

et al. 2016

Biol Trace Elem Res

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“…10,15 Although increasing attention has been given to Sb isotopes in environmental systems, 10,[17][18][19] only a few studies have investigated the Sb isotopic composition in aquatic environments, including mining sewage and seawater. 10,[20][21][22] Rouxel et al (2003) analyzed 3 123 Sb in seawater, rocks, and deep-sea sediments and reported 3 123 Sb in seawater at 3.7 ± 0.4 3 10 (3, expressed as one over ten thousand, the unit of the Sb isotope). Resongles et al (2015) showed that 3 123 Sb in the upper reaches of the Orb River was in the range of −0.6 to 1.1 3, and 3 123 Sb in the polluted Gardon River was in the range of +2.3-8.3 3.…”

Section: Introductionmentioning

confidence: 99%

“…Our approach is based on previously reported methods but with improvements in preservation, digestion, preconcentration, separation and purication processes. [9][10][11][12]15,[19][20][21][22][23][24]30,31 The new method has addressed the following issues: (1) study on the stabilization time of Sb in water samples with different acid systems. (2) Improved capacity in handling large volume samples (>100 mL) through the development of effective digestion and preconcentration.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to sample preparation for the analysis of Sb isotope ratios in natural water by MC-ICP-MS

Xia

Deng

Sun

et al. 2023

J. Anal. At. Spectrom.

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Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice

Zhang

Chen

et al. 2018

Biol Trace Elem Res

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Lead (Pb) exposure is a global environmental problem and its exposure can lead to serious renal damage by disturbing the pro-oxidant/antioxidant balance and facilitating inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenols in the diet and has been reported to have many biological properties such as antioxidant and anti-inflammatory. In this study, we aimed to investigate the protective efficacy and mechanism of CGA against Pb-induced nephrotoxicity in mice. The results showed that CGA inhibited Pb-induced bodyweight loss, reduced kidney coefficients, and alleviated renal function and structure. Exploration on the potential mechanism demonstrated that CGA suppressed Pb-induced inflammation in the kidney by regulating NF-κB pathway activation. Furthermore, CGA significantly increased Pb-induced reduction in the activity of SOD and GSH-Px, and reduced Pb-induced increase in the content of MDA. The expression of Bax and Bcl-2 associated with apoptosis was also significantly regulated by CGA. These data indicated that CGA may play a potential treatment strategy for Pb toxicity.

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Agency for Toxic Substances and Disease Registry's Toxicological Profiles: Contribution to Public Health

Cited by 11 publications

References 0 publications

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

A novel approach to sample preparation for the analysis of Sb isotope ratios in natural water by MC-ICP-MS

Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice

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