Ageing-related changes of neural activity associated with spatial contextual memory

Kukolja, Juraj; Thiel, Christiane M.; Wilms, Marcus; Mirzazade, Shahram; Fink, Gereon R.

doi:10.1016/j.neurobiolaging.2007.08.015

Cited by 58 publications

(58 citation statements)

References 62 publications

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“…This is in line with previous data implying that the hippocampal formation (Eldridge et al, 2000;Burgess et al, 2001Burgess et al, , 2002Cabeza et al, 2003;Iidaka et al, 2006;Kukolja et al, 2009) and the amygdala (Rutishauser et al, 2008) are not only involved in encoding but also mediate retrieval of context in episodic memory. Previous studies which have investigated amygdalo-hippocampal interactions in memory processes in humans have mostly used long-term and working memory paradigms involving emotional stimuli (Canli et al, 2000;Dolcos et al, 2004;Richardson et al, 2004;LoPresti et al, 2008), suggesting that the amygdala is primarily involved in emotional processing.…”

Section: Fmri Data: Retrievalsupporting

confidence: 93%

“…We used a spatial source memory task used previously by Cansino et al (2002) and Kukolja et al (2008Kukolja et al ( , 2009. Briefly, the experiment consisted of an encoding and a retrieval session.…”

Section: Methodsmentioning

confidence: 99%

“…Accordingly, in the retrieval session, items were divided into two subtypes: (3) those with those with correct spatial context retrieval (CorSCR) and (4) items with false spatial context retrieval (FalSCR). In some of the analyses, the CorSCR and FalSCR were pooled to reflect item memory rather than spatial context memory (see also Kukolja et al, 2009). All data were analyzed with repeated measures ANOVAs and drug (placebo, physostigmine) as within subject factor.…”

Section: Methodsmentioning

confidence: 99%

“…Consequently, treatment of AD has focused on pharmacological enhancement of cholin-ergic function (Lanctô t et al, 2003;Trinh et al, 2003). Possibly, also the decline of memory functions observed during normal aging (Light, 1991;Spencer and Raz, 1995;NavehBenjamin, 2000;Kukolja et al, 2009) is based on a beginning cholinergic deficit (Bartus et al, 1982;Mesulam, 1996;Cohen et al, 2006;Schliebs and Arendt, 2006). Supporting this notion, nicotinic stimulation has been shown to enhance memory performance in healthy elderly adults in several tasks including verbal and object learning, delayed recall, and word retrieval (Howe and Price, 2001;Min et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Cholinergic Stimulation Enhances Neural Activity Associated with Encoding but Reduces Neural Activity Associated with Retrieval in Humans

Kukolja¹,

Thiel²,

Fink³

2009

Journal of Neuroscience

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The cerebral cholinergic system is centrally involved in memory formation. Studies in rodents suggest that cholinergic stimulation may facilitate encoding of new information but may interfere with retrieval. We investigated the effect of cholinergic stimulation on encoding and retrieval of episodic memory in humans. We also tested whether the putative benefit of cholinergic stimulation on memory function depends on individual baseline performance. Since such effects were expected to be greatest in an older population resulting from an age-related degeneration of the cholinergic system, we recruited 22 healthy older subjects (51-68 years) for an event-related functional magnetic resonance imaging experiment. In two separate scanning sessions, subjects encoded and retrieved items and their spatial context under cholinergic stimulation or placebo with the acetylcholine-esterase inhibitor physostigmine or saline being administered intravenously in a double-blind cross-over design. Baseline performance was recorded at a separate occasion without scanning. Cholinergic stimulation enhanced neural activity for successful versus unsuccessful spatial context encoding in the right hippocampus but reduced activity for successful versus unsuccessful spatial context retrieval in the right amygdala. These data may bridge the gap between rodent and human studies by showing that also in man cholinergic stimulation enhances encoding but interferes with retrieval on a neural level. Furthermore, baseline performance negatively correlated with the effect of cholinergic stimulation. Thus, participants who were worse at baseline benefited more from cholinergic stimulation than those who had better baseline values, indicating that a cholinergic deficit contributes to the memory decline even in healthy older subjects.

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Section: Fmri Data: Retrievalsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cholinergic Stimulation Enhances Neural Activity Associated with Encoding but Reduces Neural Activity Associated with Retrieval in Humans

Kukolja¹,

Thiel²,

Fink³

2009

Journal of Neuroscience

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“…Age-related decline in brain activation in the FG during cognitive performance has been observed [49,50], suggesting that age-related decline may take place in the FG.…”

mentioning

confidence: 99%

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Premkumar

Fannon

Kuipers

et al. 2008

Behavioural Brain Research

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P r e -P r i n t AbstractThe frontal lobe has an extended maturation period and may be vulnerable to the long-term effects of schizophrenia. We tested this hypothesis by studying the relationship between duration of illness (Dol) and grey matter (GM) volume across the whole brain. Sixty-four patients with schizophrenia and 25 healthy controls underwent structural MRI scanning and neuropsychological assessment. We performed regression analyses in patients to examine the relationship between Dol and GM and cerebro-spinal fluid (CSF) volumes across the whole brain, and correlations in controls between age and GM or CSF volume of the regions where GM or CSF volumes were associated with Dol in patients. Correlations were also performed between GM volume in the regions associated with Dol and neuropsychological performance.A longer Dol was associated with lower GM volume in the left dorsomedial prefrontal cortex (PFC), right middle frontal cortex, left fusiform gyrus (FG) and left cerebellum (lobule III).Additionally, age was inversely associated with GM volume in the left dorsomedial PFC in patients, and in the left FG and CSF excess near the left cerebellum in healthy controls.Greater GM volume in the left dorsomedial PFC was associated with better working memory, attention and psychomotor speed in patients. Our findings suggest that the right middle frontal cortex is particularly vulnerable to the long-term effect of schizophrenia illness whereas the dorsomedial PFC, FG and cerebellum are affected by both a long Dol and aging. The effect of illness chronicity on GM volume in the left dorsomedial PFC may be extended to brain structureneuropsychological function relationships. 2

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Episodic Memory in Healthy Older Adults

Rajah¹,

Maillet²,

Grady³

2015

The Wiley Handbook on the Cognitive Neuroscience of Memory

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Ageing-related changes of neural activity associated with spatial contextual memory

Cited by 58 publications

References 62 publications

Cholinergic Stimulation Enhances Neural Activity Associated with Encoding but Reduces Neural Activity Associated with Retrieval in Humans

Cholinergic Stimulation Enhances Neural Activity Associated with Encoding but Reduces Neural Activity Associated with Retrieval in Humans

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Episodic Memory in Healthy Older Adults

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