Ageing reduces skin wetness sensitivity across the body

Wildgoose, Charlotte; Valenza, Alessandro; Stella, Alex Buoite; Feka, Kaltrina; Bianco, Antonino; Filingeri, Davide

doi:10.1113/ep090027

Cited by 10 publications

(24 citation statements)

References 50 publications

(70 reference statements)

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“…Skin biophysical characteristics (as skin hydration) might influence skin and thermal wetness perception 31 ; in this study, we were not able to collect such data, although any effect of migraine on such characteristics should not be expected. The involvement of TRPM-8 receptors should be further investigated, given their already elucidated role in the disposition to migraine and the modulation of skin wetness sensation.…”

Section: Limitations and Future Perspectivesmentioning

confidence: 84%

“…Patients had to be pain‐free during the measurements that were performed at least 72 h before or after the cessation of a migraine attack and/or use of analgesic medications. Based on sex and age distribution, a sample of similar controls was selected from a normative dataset from healthy participants assessed with identical procedures as the ones described here, during this and other experiments conducted in our laboratories (36 individuals were selected from 40) 30,31 . To account for interindividual differences, a sample size at least three times greater than the migraine sample was selected.…”

Section: Methodsmentioning

confidence: 99%

“…These analyses established the generalized effect of migraine on wetness and thermal sensing over the different tested areas, and its interaction with stimulus temperature. 31 In the event of statistically significant main effects or interactions, post hoc analyses were conducted with Sidak's test. Normality testing using the Shapiro-Wilk test was performed for all datasets.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Based on sex and age distribution, a sample of similar controls was selected from a normative dataset from healthy participants assessed with identical procedures as the ones described here, during this and other experiments conducted in our laboratories (36 individuals were selected from 40). 30,31 To account for interindividual differences, a sample size at least three times greater than the migraine sample was selected. Specifically, we were able to devise normative values for cold-wetness, neutral-wetness, and warmwetness sensing based on 36 for the forehead and posterior neck, and on 16 for the finger pad.…”

Section: Introductionmentioning

confidence: 99%

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Skin wetness sensitivity across body sites commonly affected by pain in people with migraine

et al. 2022

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Objective:The objective of this study was to evaluate skin wetness perception and thermal sensitivity in people with migraine and similar healthy controls.Background: Environmental triggers, such as cold and humidity, are known triggers for pain in people with migraine. Sensory inputs might be implicated in such heightened responses to cold-humid environments, such that a migraine-induced hypersensitivity to cold wetness could be present in people with migraine. However, we lack empirical evidence on skin thermal and wetness sensitivity across skin sites commonly associated with reported pain in migraine, such as the forehead.Methods: This prospective cross-sectional observational study, conducted in a university hospital setting, evaluated skin wetness perceptions and thermal sensations to wet non-noxious warm-wet, neutral-wet, and cold-wet stimuli applied to the forehead, the posterior neck, and the index finger pad of 12 patients with migraine (mean and standard deviation for age 44.5 ± 13.2 years, 7/12 [58%] women) and 36 healthy controls (mean and standard deviation for age 39.4 ± 14.6 years, 18/36 [50%] women).Results: On the forehead, people with migraine reported a significantly higher wetness perception than healthy controls across all thermal stimulus (15.1 mm, 95% confidence interval [CI]: 1.8 to 28.5, p = 0.027, corresponding to ~ 15% difference), whereas no significant differences were found on the posterior neck nor on the index finger pad.We found no differences among groups in overall thermal sensations (−8.3 mm, 95% CI:

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Section: Limitations and Future Perspectivesmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Skin wetness sensitivity across body sites commonly affected by pain in people with migraine

et al. 2022

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“…To leverage a larger normative data set than the one provided by the 11 CTR participants tested in the current study, we utilized additional data from healthy participants assessed with identical procedures as the ones described here, during other experiments conducted in our laboratory. These data sets were those presented by Valenza et al ( 24 ) (i.e., N = 20; 10 young males and 10 young females) and Wildgoose et al ( 30 ) ( N = 20; 10 younger and 10 older males), which included assessments of static cold-, neutral-, and warm-wetness sensitivity over the forehead and finger pad. Specifically, on combination of the 3 normative data sets (see Supplemental material; all Supplemental material is available at https://doi.org/10.17028/rd.lboro.16716922.v1 ), we were able to devise normative values for cold-, neutral-, and warm-wetness sensing based on an n = 51 for the forehead, and on an n = 31 for the finger pad.…”

Section: Methodsmentioning

confidence: 99%

Regional skin wetness perception and its modulation by warm and cold whole body skin temperatures in people with multiple sclerosis

Christogianni

Bibb

Filtness

et al. 2022

American Journal of Physiology-Regulatory, Integrative and Comp

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Skin wetness sensing is important for thermal stress resilience. Individuals with Multiple Sclerosis (MS) present greater vulnerability to thermal stress; yet it is unclear whether they present wetness sensing abnormalities. We investigated the effects of MS on wetness sensing and their modulation with changes in mean skin temperature (Tsk). Twelve MS participants (5M/7F; 48.3±10.8y; EDSS range: 1-7), and 11 healthy controls (4M/7F; 47.5±11.3y) undertook three trials, during which they performed a quantitative sensory test with either a thermo-neutral (30.9°C), warm (34.8°C), or cold (26.5°C) mean Tsk. Participants reported on visual analogue scales local wetness perceptions arising from the static and dynamic application of a cold-, neutral-, and warm-wet probe (1.32cm2; water content: 0.8ml), to the index-finger pad, forearm, and forehead. Data were analysed for the group-level effect of MS, as well as for its individual variability. Our results indicated that MS did not alter skin wetness sensitivity at a group level, across the skin sites and temperature tested, neither under normothermia nor under conditions of shifted thermal state. However, when taking an individualised approach to profiling wetness sensing abnormalities in MS, we found that 3 out of the 12 MS participants (i.e. 25% of the sample) presented a reduced wetness sensitivity on multiple skin sites, and to different wet stimuli (i.e. cold-, neutral-, and warm-wet). We conclude that some individuals with MS may possess reduced wetness sensitivity; however, this sensory symptom may vary greatly at an individual level. Larger-scale studies are warranted to characterise the mechanisms underlying such individual variability.

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Remapping Wetness Perception in Upper Limb Amputees

Ploumitsakou,

Muheim,

Felouzis

et al. 2024

Advanced Intelligent Systems

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Recent research has made remarkable strides in restoring sensory feedback for prosthetic users, including tactile, proprioceptive, and thermal feedback. Herein, a sensory modality that has been largely neglected is explored: the ability to perceive wetness. Providing moisture‐related information to prosthesis users can increase their overall sensory palette toward a more natural sensory experience. A rapid decrease in skin temperature is found to trigger the illusion of contact with something wet. Two body parts were tested, the upper arm and the lateral abdomen, in a group of non amputated participants, and it was found that a wetness sensation can be elicited and maintained for at least 10 s in 86% and 93% of participants, respectively. It is then demonstrated how to mediate the wetness sensation in real‐time using a thermal wearable device that mimics the thermal properties of the skin. Finally, two upper limb amputee individuals used their prosthetic arm, sensorized with the device, to discriminate between three levels of moisture; their detection accuracy was similar to one they had with their intact hands. The current study is a stepping stone for future prostheses aimed at restoring the richness of sensory experience in upper limb amputees.

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Ageing reduces skin wetness sensitivity across the body

Cited by 10 publications

References 50 publications

Skin wetness sensitivity across body sites commonly affected by pain in people with migraine

Skin wetness sensitivity across body sites commonly affected by pain in people with migraine

Regional skin wetness perception and its modulation by warm and cold whole body skin temperatures in people with multiple sclerosis

Remapping Wetness Perception in Upper Limb Amputees

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