AGEing of Collagen: The Effects of Glycation on Collagen’s Stability, Mechanics and Assembly
Daniel Sloseris,
Nancy R. Forde
Abstract:Advanced Glycation End Products (AGEs) are the end result of the irreversible, non-enzymatic glycation of proteins by reducing sugars. These chemical modifications accumulate with age and have been associated with various age-related and diabetic complications. AGEs predominantly accumulate on proteins with slow turnover rates, of which collagen is a prime example. Glycation has been associated with tissue stiffening and reduced collagen fibril remodelling. In this study, we investigate the effects of glycatio… Show more
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