Ageing, Monoamines, and Monoamine-Oxidase Levels

Age-Related Differences in Catecholamine Fluorescence of Human Vascular Tissue

“…However, it is stressed that the present results are qualitative rather than quantitative. These findings are consistent with the results of a quantitative study in brain tissue by Robinson et al [1972], who reported a progressive fall in the noradrenaline content of the tissue with increasing age. A further finding of the latter workers was that monoamine oxidase activity increased markedly in the brain tissue after the age of 35 years.…”

Changes in Neuroendocrine Control of Anterior Pituitary Function during Aging

“…PRL-secreting microadenomas often are found in young as well as in elderly individuals of both sexes. A decrease has been reported in brain catechol amines of old human subjects [25] which may contribute to development of these pituitary tumors. There is no definite evidence that prolonged estrogen or other steroid stimula tion can produce prolactinomas in humans [22], although estrogens can stimulate increased PRL secretion in men and women [7],…”

Biochemistry of Mental Depression

“…Robinson and his colleagues (70,72) have measured the concentration of noradrenaline in the hindbrain of 55 patients and have been able to demonstrate that decade by decade the concentration of this amine decreases. The finding is consistent with the increasing concentration of MAO in the brain with age.…”