Ageing in Iran

Danial, Zahra; Motamedi, Mohammad Hosein Kalantar; Mirhashemi, Seyyed Mehdi; Kazemi, Alireza; Mirhashemi, Amir Hossein

doi:10.1016/s0140-6736(14)62278-9

Cited by 29 publications

(25 citation statements)

References 2 publications

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“…According to the previous studies in Iran, CRC is the fourth most common cancer in Iranian men after gastric, bladder, and prostate cancers, and the second most common cancer in Iranian women. The existing reports unravel >4000 new cases of CRC are diagnosed every year in Iran [8,19]. Though the incidence of CRC in Iran is relatively low compared to many countries, it is worryingly increasing [18].…”

Section: Discussionmentioning

confidence: 99%

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Ranjbary

Mehrzad

Abdollahi

et al. 2019

Preprint

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Background: The incidence of colorectal cancer (CRC) is rising, worldwide, and is attributed to genetics and epigenetic factors. We aimed to evaluate the key clinicodemographical/epidemiological-and molecular impacts on metastatic CRC in CRC patients from a highly populated area in northeastern Iran. Retrospective clinical materials-based cohort design and patients were analyzed with respect to age, sex, colorectum anatomy, metastasis, mortality as well as to expression of molecular markers B3GALNT2, mucin I ( MUC1), P53 and Ki67. Methods: Patients, 6260 registered CRC with 3829 underwent surgery, from three medical university hospitals in the study area, during 2006-2016, were analyzed for the clinicodemographic aspects of age, sex, stage of CRC, history of smoking, familial/occupational status and post-surgery survival period as well as mRNA/protein expression of B3GALNT2, MUC1, P53 and Ki67. Factors were set to estimate mortality and risk of metastatic CRC. Results: ~61%, ~33% and ~6% of adenocarcinomatous CRC were located in colon, rectum and rectosigmoid, respectively, of which younger-and older than 50 was mainly in transvers colon-and colorectum, respectively. Post-surgery survival period of metastatic CRC patients was remarkably longer in patients aged > 50 than those < 50 years old, and worse in females than males. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression in metastatic stage III CRC were highly associated with increased metastasis and mortality. B3GALNT2 high , MUC1 high , P53 low and Ki67 high mRNA/protein expression correlated with increased risk of a progressed CRC state and mortality. The risk to develop metastatic CRC was higher in males, younger, urban residing-and employed individuals, indicative of a plausible non-genetics/epigenetics contribution to CRC. Conclusions: The role of possible diagnostic biomarkers, B3GALNT2, MUC1 and Ki67, but not P53, in the etiology/early detection of metastatic CRC is promising. Epigenetic contribution to metastatic CRC risk is predominant.

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Section: Discussionmentioning

confidence: 99%

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Ranjbary

Mehrzad

Abdollahi

et al. 2019

Preprint

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“…On the other hand, the results of a prediction study (using Box-Jenkins models) show an increasing trend of TB cases in Iran [58]. Considering the fact that Iran has long borders with Afghanistan and Pakistan which are regarded as high-burden countries for TB in the Eastern Mediterranean Region, in addition to the low efficacy of BCG vaccine, increasing trend of TB cases in Iran, especially in over 65 year-old people and the ageing population (10.5% and 21.7% of total population in 2020 and 2050, respectively) [59], call for an urgent and comprehensive program for prevention and control of TB in this country.…”

Section: Tb In Iranmentioning

confidence: 99%

BCG vaccine and pulmonary tuberculosis

Tafreshi

2016

vacres

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Tuberculosis (TB) is one of the most important public health problems in the world and has been declared as a global emergency by the World Health Organization (WHO) in 1993. Bacillus Calmette-Guérin (BCG) is one of the first developed vaccines to prevent TB. Unfortunately, BCG vaccine has had a limited duration of protection and has shown controversial and variable levels of efficacy, especially against pulmonary TB. On the other hand, efforts in production of new forms of this vaccine have been in vain and revaccination is not considered as a suitable strategy to control the disease. Considering that TB affects adults mostly between the ages of 15 and 59, pulmonary TB is more common than disseminated TB and BCG vaccine has had a minimal effect on the global burden of pulmonary TB. Before introducing a new, safe and effective vaccine, combined strategies in the field of control and treatment of TB rather than vaccination are necessary.

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“…The MOHME is the main provider of inpatient health services owning the majority of hospital beds (70%), with the remaining hospital beds belonging to social security organization (11%), private sector (15%), military hospitals, oil company hospitals, and others (4%) . Iran's health system suffers from some challenges in financing, human resources, service quality, aging, and non‐communicable diseases …”

Section: Iran's Health Systemmentioning

confidence: 99%

Informal caregivers in hospitals: Opportunities and threats

Amiresmaili

Emrani

2018

Health Planning & Management

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This study shows some roles for informal caregivers including mental supports, consultation, decision-making, and care roles. Concerning the shortage of manpower in Iran's hospitals, nurses have less time to take care of each patient; therefore, using informal caregivers as an implicit strategy to overcome nursing shortage and to reduce hospital costs seems to be beneficial. We suggest that an appropriate plan is necessary to make use of them for filling this gap to some extent, as well as providing training sessions and facilities for companions acting as informal caregivers.

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Ageing in Iran

Cited by 29 publications

References 2 publications

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

BCG vaccine and pulmonary tuberculosis

Informal caregivers in hospitals: Opportunities and threats

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