Ageing and cardiovascular responses to head-up tilt in healthy subjects

Tahvanainen, Anna; Leskinen, Miia; Koskela, Jenni; Ilveskoski, Erkki; Nordhausen, Klaus; Oja, Hannu; Kähönen, Mika; Kööbi, Tiit; Mustonen, Jukka; Pörsti, Ilkka

doi:10.1016/j.atherosclerosis.2009.06.001

Cited by 38 publications

(43 citation statements)

References 23 publications

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“…In the healthy adult, these events stimulate the baroreflex, which increases sympathetic activity leading to an increase in heart rate and vasoconstriction of the resistance and capacitance vessels in the lower limbs (4). These mechanisms act to restrict the degree of blood pooling and permit the restoration of cardiac output and blood pressure (24,28). In contrast, a blunted baroreflex response or a failure to elevate vascular resistance leads to excessive blood pooling in the legs and indicates an impaired autonomic nervous system (25,26).…”

Section: Introductionmentioning

confidence: 99%

The validity and reliability of continuous-wave near-infrared spectroscopy for the assessment of leg blood volume during an orthostatic challenge

et al. 2016

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DisclaimerThe University of Gloucestershire has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material.The University of Gloucestershire makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited.The University of Gloucestershire makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights.The University of Gloucestershire accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. PLEASE SCROLL DOWN FOR TEXT. ABSTRACTNear-infrared spectroscopy (NIRS) can potentially be used to assess the cardiovascular autonomic system by monitoring orthostatic challenge-induced shifts in lower limb blood volume. However, in order to be of clinical utility the test must be valid, reliable, and relatively simple to conduct. reliability. This orthostatic test may present a relatively simple and inexpensive approach for assessing the cardiovascular autonomic nervous system. Abstract word count: 248

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Section: Introductionmentioning

confidence: 99%

The validity and reliability of continuous-wave near-infrared spectroscopy for the assessment of leg blood volume during an orthostatic challenge

et al. 2016

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“…However, previous studies have demonstrated change in posture (supine to seated) to decrease shear stress and increase the vascular tone of these vessels, 29,30 which would be expected to increase AIx. Similarly, previous studies have shown total peripheral resistance to increase during tilt-table testing, 17,22 which would indicate increased tone of the small vessel beds. 31 The forward travelling wave is determined by cardiac function, including heart rate and stroke volume.…”

Section: Reliability Of Central Hemodynamic Responsesmentioning

confidence: 99%

“…The remainder of the response may be explained by the large drop in stroke volume which occurs in response to an orthostatic challenge. 17,22 While not yet validated for use with oscillometric devices, the interpretation of future studies would be aided through the addition of the emerging wave reflection magnitude method, 33,34 which includes decomposition of forward and backward pressure waves. The AIx and wave reflection magnitude are likely to provide complimentary information; AIx provides an integrated summary of the relations among reflected wave timing, amplitude, and ventricular function, whereas reflection magnitude is less likely to be influenced by confounding variables, including heart rate.…”

Section: Reliability Of Central Hemodynamic Responsesmentioning

confidence: 99%

Reliability of oscillometric central hemodynamic responses to an orthostatic challenge

et al. 2015

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“…A decrease of arterial compliance, depending on age, is accelerated in varied cardiovascular disorders [3]. With increasing age, the cardiovascular system loses its efficiency and large arteries dilate and stiffen as a result of changes in the vessel wall [4], [5].…”

Section: Introductionmentioning

confidence: 99%