Aged Red Garlic Extract Suppresses Nitric Oxide Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages Through Inhibition of NF-<i>κ</i>B

Ryu, Jinhyun; Park, Hye-Jin; Jeong, Yi-Yeong; Han, Sunkyu; Shin, Jung-Hye; Lee, Soo Jung; Kang, Min Jung; Sung, Nak‐Ju; Kang, Dawon

doi:10.1089/jmf.2014.3214

Cited by 19 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As oxidative stress is thought to be the mechanism through which dengue virus acts to trigger the pro-inflammatory immune response during infection, and garlic has previously been shown to suppress nitric oxide production [ 28 ], inhibit oxidative injury [ 29 ] and decrease reactive oxygen species (ROS) levels [ 32 ], we examined the anti-oxidant activity of garlic organosulfur compounds during dengue virus infection. Oxidative stress induced by lipid peroxidation has been shown to contribute to inflammation.…”

Section: Resultsmentioning

confidence: 99%

“…The results of these studies suggest that blocking the oxidative stress response may reduce the pro-inflammatory response leading to severe symptoms in dengue virus infection. Garlic has been shown to suppress nitric oxide production through the inhibition of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), downregulating expression of inducible nitric oxide synthase (iNOS) and blocking nuclear translocation of NF-κB [ 28 ]. Garlic has also been found to inhibit oxidative injury in liver through adenosine monophosphate (AMP)-activated protein kinase [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

Hall

Troupin

Londoño-Rentería

et al. 2017

Viruses

View full text Add to dashboard Cite

Dengue virus (DENV) is a mosquito-borne flavivirus that causes significant global human disease and mortality. One approach to develop treatments for DENV infection and the prevention of severe disease is through investigation of natural medicines. Inflammation plays both beneficial and harmful roles during DENV infection. Studies have proposed that the oxidative stress response may be one mechanism responsible for triggering inflammation during DENV infection. Thus, blocking the oxidative stress response could reduce inflammation and the development of severe disease. Garlic has been shown to both reduce inflammation and affect the oxidative stress response. Here, we show that the garlic active compounds diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin reduced inflammation during DENV infection and show that this reduction is due to the effects on the oxidative stress response. These results suggest that garlic could be used as an alternative treatment for DENV infection and for the prevention of severe disease development.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

Hall

Troupin

Londoño-Rentería

et al. 2017

Viruses

View full text Add to dashboard Cite

show abstract

“…Although a recent research paper reported that the antiinflammatory activity of garlic OSCs help reduce TNF-α, IL-6, and iNOS [120], whether DADS can suppress inflammatory bowel disease and the molecular mechanisms haven't been investigated yet [116]. Many studies has been shown that DADS could suppress nitric oxide production through inhibiting the activation of NF-κB (nuclear factor kappa B), and attenuating expression of inducible nitric oxide synthase (iNOS) and blocking the nuclear translocation of NF-κB [121].…”

Section: The Inhibition Of Inflammation By Dadsmentioning

confidence: 98%

The Progress of Diallyl Disulfide in Anti-Cancer

Lz¹,

Liao²,

Wang³

et al. 2017

Chemotherapy

View full text Add to dashboard Cite

Considerable evidence in recent years suggests that garlic has anti-proliferative effects on various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds (OSCs), such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than watersoluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can reduce carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. The mechanisms of these action of DADS include activation of metabolic enzymes that detoxify carcinogens, suppression of the formation of DNA adducts, antioxidant effects, regulation of cell-cycle progression, induction of apoptosis, and inhibition of angiogenesis and metastasis. These topics are discussed in depth in this review.

show abstract

“…LPS activates NF-κB, a transcription factor that is involved in inflammatory response. Previous studies have indicated that aged red garlic extract and garlic oil derivatives such as DAS, DADS, and allyl methyl sulfide (AMS) could exert anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages through inhibition of iNOS expression, NO production, prostaglandin E 2 (PGE 2 ), and NF-κB (Liu et al, 2006;Shin et al, 2013;Lee et al, 2015;Ryu et al, 2015). ASC, an analogue of garlic compound, has been shown to exert an inhibitory effect on the growth of TM12 cells through modulating the expression of cell cycle regulatory proteins, inducing the loss of DNA integrity, and increasing the rate of apoptosis (Zhu et al, 2000a;Zhu et al, 2000b;Jiang et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Promoting effect of Se-allylselenocysteine on 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Cheng¹,

Jiang²,

Hsiao³

et al. 2020

JFB

View full text Add to dashboard Cite

Se-allylselenocysteine (ASC), an analogue of garlic compound, has been shown to inhibit mammary carcinogenesis in vivo and cell growth in vitro. However, the function of ASC on anti-inflammatory effects remains largely unknown. Therefore, we investigated whether ASC has an anti-inflammatory effect on lipopolysaccharide (LPS) -induced inflammation or an anti-tumour effect promoting on DMBA/TPA-induced skin tumorigenesis and tried to elucidate the mechanisms involved. Herein, the results showed that ASC inhibited LPS-induced production of nitric oxide (NO) with a decreased protein level of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. However, ASC enhanced LPS-induced cyclooxygenase-2 (COX-2) protein levels and mRNA expression. Interestingly, we found for the first time that topical application of ASC on the dorsal skin of DMBA-initiated and TPA-promoted mice significantly accelerated skin tumorigenesis and raised tumour multiplicity as compared to the positive control group (DMBA/TPA). The number of tumours that were 1–3 mm, 3–5 mm, and >5 mm in size per mouse increased in a dose-dependent manner in the ASC pre-treated groups. Pre-treatment with ASC showed a significant increase in the expression of COX-2 compared with the positive control group. In summary, that ASC may modulate the COX-2 protein expression and promoting DMBA/TPA-induced skin cancer in mice.

show abstract

Aged Red Garlic Extract Suppresses Nitric Oxide Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages Through Inhibition of NF-κB

Cited by 19 publications

References 36 publications

Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stress during Dengue Virus Infection

The Progress of Diallyl Disulfide in Anti-Cancer

Promoting effect of Se-allylselenocysteine on 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Contact Info

Product

Resources

About