Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury

Song, Hui‐Fang; He, Sheng; Li, Shuhong; Wu, Yin; Wu, Jun; Guo, Jian; Shao, Zhengbo; Zhai, Xiaoyan; Gong, Hui; Lu, Li; Fang, Wei; Weisel, Richard D.; Xie, Jun; Li, Ren‐Ke

doi:10.1016/j.jacbts.2017.07.014

Cited by 34 publications

(28 citation statements)

References 24 publications

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“…sGene, genes encoding secreted proteins; sLungGenes, genes encoding secreted proteins that are preferentially expressed in the adult lung; z-P Lung , lung-preferential expression Z score. mesenchymal stromal cells (57,58). Our analysis of the human and mouse tissue databases indicated preferential expression of Ndnf in the normal adult lung in humans (Figure 1 and Supplemental Figures 1 and 2) and mice ( Figure 1 and Supplemental Figure 3), which we validated using several approaches.…”

Section: Resultsmentioning

confidence: 57%

Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

Zhang

Kai

et al. 2019

JCI Insight

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Section: Resultsmentioning

confidence: 57%

Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

Zhang

Kai

et al. 2019

JCI Insight

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“…Recently, several strategies have been explored to rejuvenate senescent MSCs, and subsequently enhance their functions. Overexpression of neuron-derived neurotrophic factor was found to rejuvenate aged BM-MSCs and improve their function in repairing the aged heart after ischemia [82]. microRNA (miR)-10a rejuvenated aged BM-MSCs and enhanced the cardiacprotection following infarction in mice via increased paracrine effects [83].…”

Section: Msc Functionsmentioning

confidence: 99%

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Fan

Zhang

et al. 2020

Cell. Mol. Life Sci.

369

282

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Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms underlying the tissue regenerative properties and immunomodulatory effects of MSCs. We focused on discussing the functional roles of paracrine activities, direct cell-cell contact, mitochondrial transfer, and extracellular vesicles related to MSC-mediated effects on immune cell responses, cell survival, and regeneration. This will provide an overview of the current research on the rapid development of MSC-based therapies. Keywords Regenerative potential • Integration of MSCs • Immunomodulation • Soluble factors • Cell-cell contact • Mitochondrial transfer • Extracellular vesicles Abbreviations AHR Airway hyper-responsiveness Alix ALG-2-interacting protein X Ang-1 Angiopoietin-1 ASCs Adipose-derived stem cells BAX BCL-2-associated X protein BCL-2 B-cell lymphoma 2 CASP3 Caspase 3 CX43 Connexin 43 CXCR4 Chemokine receptor type 4 DC Dendritic cell Cellular and Molecular Life Sciences

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“…Recently, it was proved that young rat MSCs experienced robust tissue genesis [49] . It was confirmed that reduced regenerative capacity of aged stem cells hampers organ regeneration, but not migration due to injury [50] .…”

Section: Discussionmentioning

confidence: 84%

Sexual Dimorphism in Relation to Structural Changes in Renal Cortex in Different Age Groups: Possible Role of Endogenous SCs

Zickri

Hamoud

2019

Egyptian Journal of Histology

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Background: Chronic kidney disease (CKD) is an inevitable process which might be the major cause of death in senile age. In certain diseases male gender is a risk factor. The mitotic division of resident SCs might be stimulated by cellular injury and contribute to the restoration of damaged cells. Aim of study: The current study is designed to study the sexual dimorphism in relation to structural changes in the renal cortex in prepubertal, pubertal and postpubertal age groups of rat. In addition, possible role of endogenous stem cells (SCs). Materials and methods: Thirty albino rats were divided into three groups, Pre-pubertal, pubertal and post-pubertal each was subdivided into two subgroups male and female respectively. The body weight (BW), kidney weight (KW), cross sectional area (CA) and serum creatinine (sC) were determined. Kidney sections were subjected to histological, histochemical, immunohistochemical, morphometric and statistical studies. Results: BW and glomerular area values recorded age related changes. While KW, CA, sC, count of dark nuclei, area of collagen, thickness of tubular basement membrane, count of proliferation marker proved age and sex related changes. Conclusion: Progressive age related increase in BW, KW, CA, sC and glomerular area (GA) was found, that became reciprocal for the GA in postpubertal rats due to atrophy. Elevated sC, enhanced apoptosis, fibrosis and thickened tubular basement membrane (tBM) and reduced cellular proliferation were detected. Enhanced SCs migration in response to injury were more noticeable in male postpubertal rats.

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Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury

Abstract: Visual Abstract

Cited by 34 publications

References 24 publications

Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

Sexual Dimorphism in Relation to Structural Changes in Renal Cortex in Different Age Groups: Possible Role of Endogenous SCs

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