Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats

Alkreathy, Huda M.; Damanhouri, Zoheir A.; Ahmed, Nessar; Slevin, Mark; Ali, Soad Shaker; Osman, Amira

doi:10.1016/j.fct.2010.01.005

Cited by 79 publications

(62 citation statements)

References 34 publications

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“…61 In addition, recent studies demonstrated the bioavailability of grape seed proanthocyanidins to the target organs exhibiting a superior protection against oxidative DNA damage and oxidative stress relative to vitamin C, E and β-carotene. 12 In support of our findings, it has been reported that various chemical compounds such as carvedilol, 62 rosmarinic acid, 63 dexrazoxane 64,65 as well as herbal agents including GSE, 18,39 saffron extract 66 and garlic extract 67 found to potentially be protective against DOX-induced cardiotoxicity. Based on reported studies GSE produces protective effect by several mechanisms including antioxidant effect, 68,69 decreasing the number of apoptotic cells, 70 prevention of DNA fragmentation, 15,71 regulation of the expression levels of the pro-apoptotic protein Bax-alpha, 72 increasing antiapoptotic protein Bcl-2 73 and inhibition of apoptotic signaling pathways.…”

Section: Cardioprotective Effect Of Grape Seed Extractsupporting

confidence: 75%

Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats

Razmaraii¹,

Babaei²,

Nayebi³

et al. 2016

Adv Pharm Bull

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Section: Cardioprotective Effect Of Grape Seed Extractsupporting

confidence: 75%

Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats

Razmaraii¹,

Babaei²,

Nayebi³

et al. 2016

Adv Pharm Bull

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“…As a global inflammatory marker and a critical component of the immune system, high-sensitivity C-reactive protein (hsCRP) is widely used to assess patient health [24]. Lipshultz et al 2005 [52] showed that the survivors of childhood acute lymphoblastic leukemia (ALL) had significantly elevated levels of hsCRP when compared to levels in sibling controls. In this experiment, MDA levels were significantly increase (P<0.05) in the cardiotoxic rats as compared with sham group.…”

Section: Discussionmentioning

confidence: 99%

Effects of caffeic acid on doxorubicin induced cardiotoxicity in rats

Mohammad¹,

Aharis²,

Yousif³

et al. 2013

AJBM

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Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, its use is limited by the development of life-threatening cardiomyopathy.Doxorubicin generates free radicals and induces oxidative stress associated with cellular injury. Further, it has been shown that free radicals are involved in doxorubicin-induced toxicity. The goal of this study is to investigated the cardio-protective effects of caffeic acid on doxorubicin induced cardiotoxicity. The rats were randomized into three equal groups, sham group without treatment, doxorubicin treated group at a dose 3mg/kg IP every other two days and group treated with doxorubicin plus caffeic acid 40mg/day. Two weeks later LV function measurment were performed and blood samples were collected from the heart to measurment plasma levels of cardiac troponin-I (cTn-I), oxidative stress parameter malondialdehyde (MDA) and high a sensitive c-reactive protein (hs-CRP). The hearts were excised for cardiac tissue cytokines (TNF-α, IL-1β, IL-10) measurement and microscopic examination. Rats in the Dox+caffeic acid group had improved LV function, reduced cytokine expression, decreased myocardial marker injury (cTn-I) and less MDA, hs-CRP levels in comparison with the Dox group. Pathological finding appeared nearly normal in the Dox+caffeic acid without fibrosis. The results of the present study reveal that caffeic acid has a promising cardioprotective effect against doxorubicin-induced cardiotoxicity.

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“…This finding indicates that these doses led to 0.59 times lower risk of decreased SOD levels compared to cumulative doxorubicin doses of <90 mg/m 2 . However, this outcome was not statistically significant, nor was it consistent with a study by Akreathy et al 11 which examined cardiotoxicity caused by doxorubicin in mice. They found that doxorubicin reduced total serum antioxidant levels, increasing cardiotoxicity (P<0.05).…”

Section: Resultsmentioning

confidence: 39%