Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women

Thomasini, Ronaldo Luis; Pereira, Daniele Sirineu; Pereira, Fabiana Souza Máximo; Mateo, Elvis Cueva; Mota, Thamires Nader; Guimarães, Gabrielle Gontijo; Pereira, Leani Souza Máximo; Lima, Cristiano Xavier; Teixeira, Mauro Martins; Teixeira, Antônio Lúcio

doi:10.1371/journal.pone.0180841

Cited by 52 publications

(49 citation statements)

References 35 publications

(42 reference statements)

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“…However, reactivation of HCMV infection is also common at old age, probably reflecting weakening immune control 37 . Detection of viral DNA increases after the age of 60–70 years 110 , 111 , and viral DNA is frequently detected in urine and plasma of elderly people 112 , 113 .…”

Section: Epidemiological Convergencementioning

confidence: 99%

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

Cobelens¹,

Nagelkerke

Fletcher

2018

F1000Res

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Although several factors are known to increase the risk of tuberculosis, the occurrence of tuberculosis disease in an infected individual is difficult to predict. We hypothesize that active human cytomegalovirus infection due to recent infection, reinfection or reactivation plays an epidemiologically relevant role in the aetiology of tuberculosis by precipitating the progression from latent tuberculosis infection to disease. The most compelling support for this hypothesis comes from the striking similarity in age-sex distribution between the two infections, important because the age-sex pattern of tuberculosis disease progression has not been convincingly explained. Cytomegalovirus infection and tuberculosis have other overlapping risk factors, including poor socio-economic status, solid organ transplantation and, possibly, sexual contact and whole blood transfusion. Although each of these overlaps could be explained by shared underlying risk factors, none of the epidemiological observations refute the hypothesis. If this interaction would play an epidemiologically important role, important opportunities would arise for novel approaches to controlling tuberculosis.

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Section: Epidemiological Convergencementioning

confidence: 99%

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

Cobelens¹,

Nagelkerke

Fletcher

2018

F1000Res

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“…The impact of cytomegalovirus infection HIV-infected [14] and transplant patients [15] is well recognized. Most recently, the cytomegalovirus has been associated with immunosenescence and, perhaps, frailty syndrome in the elderly [16]. It is not clear whether is the virus that modulates the immune system as a mechanism of evasion or the immune system declines along with the aging and to allow the virus replication.…”

Section: Cytomegalovirusmentioning

confidence: 99%

Introductory Chapter: Human Herpesvirus - A Short Introduction

Thomasini¹

2020

Human Herpesvirus Infection - Biological Features, Transmission, Symptoms, Diagnosis and Treatment

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“…Interestingly, while older persons have a similar number of T cells than younger persons, they have a higher frequency of senescent T cells ( 50 , 51 ). Older persons also have higher levels of EBV and CMV in the blood than younger persons ( 52 , 53 ), and older persons may develop EBV lymphoproliferative disorders in the absence of an immune deficiency disease ( 54 ). Thus, an increased number of senescent T cells has been associated with impaired control of EBV and CMV infections.…”

Section: Mechanism For Impaired Control Of Herpesvirus Infections In mentioning

confidence: 99%

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome

Cohen

2018

Front. Immunol.

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The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. They present with lymphoproliferation and often have infections, particularly recurrent respiratory infections and/or severe virus infections. The most frequent virus infections are due to Epstein–Barr virus (EBV) and cytomegalovirus (CMV); patients often present with persistent EBV and/or CMV viremia, EBV lymphoproliferative disease, or CMV lymphadenitis. No patients have been reported with CMV pneumonia, colitis, or retinitis. Other herpesvirus infections have included herpes simplex pneumonia, recurrent zoster, and varicella after vaccination with the varicella vaccine. Additional viral infections have included adenovirus viremia, severe warts, and extensive Molluscum contagiosum virus infection. The increased susceptibility to virus infections in these patients is likely due to a reduced number of long-lived memory CD8 T cells and an increased number of terminally differentiated effector CD8 T cells.

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Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women

Cited by 52 publications

References 35 publications

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

Introductory Chapter: Human Herpesvirus - A Short Introduction

Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome

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