Age, weight and circulating concentrations of total testosterone are associated with the relative prostatic size in adult intact male dogs

Holst, Bodil Ström; Nilsson, Sanna

doi:10.1016/j.theriogenology.2022.12.047

Cited by 4 publications

(9 citation statements)

References 44 publications

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“…The dogs that presented with the lowest serum testosterone concentrations all showed poor semen quality (either low total sperm count or low MNS). We could also nd a decrease in testosterone and FAI with age in our samples, in agreement to previously reported [14]. These observations are expected, as testosterone correlates with spermatogenesis and decreases with age in both men [50] and dogs [14].…”

Section: Discussionsupporting

confidence: 92%

“…We could also nd a decrease in testosterone and FAI with age in our samples, in agreement to previously reported [14]. These observations are expected, as testosterone correlates with spermatogenesis and decreases with age in both men [50] and dogs [14]. It is interesting that the correlation with age could be observed even though we were not able to standardize the sampling in regards of time of the day, as testosterone concentrations uctuate.…”

Section: Discussionsupporting

confidence: 90%

“…The median (IQR) sperm motility in dogs with >10 ng/ml AMH in serum was 5% (0-7.5) compared to in dogs with AMH <10 ng/ml, 75% (59-80). Similarly, the MNS count was 15% (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) in dogs with AMH >10 ng/ml and 53% in dogs with AMH <10 ng/ml. There were too few observations to investigate speci c defects in samples with AMH >10ng/mL.…”

Section: Correlation Between Biomarkers and Semen Qualitymentioning

confidence: 97%

“…Testosterone is produced by the Leydig cell in response to the secretion of luteinizing hormone (LH) and is responsible to the development of male characteristics. The concentration of testosterone is lower in men with inferior sperm quality and decreases with age in both men and male dogs [13,14]. Insulin-like peptide 3 (INSL-3) is also produced by the Leydig cell but rather re ects the chronic status of the hypothalamic-pituitarygonadal axis [15].…”

Section: Introductionmentioning

confidence: 99%

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Endocrine and dog factors associated with semen quality

Hallberg,

Olsson,

Lau

et al. 2023

Preprint

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Knowledge of factors associated with semen quality may help in investigations of the aetiology and pathophysiology. We investigated the correlation between biomarkers for testicular cell function (anti-müllerian hormone, AMH, Inhibin B, testosterone, steroid-hormone binding globulin, SHBG, insulin like peptide 3, INSL-3), alkaline phosphate (ALP), canine prostate-specific esterase (CPSE), and heterophilic antibodies with dog variables, semen quality, and fertility. Blood and semen were collected from 65 Bernese Mountain Dogs. We evaluated total sperm count, motility and morphological parameters. The semen quality ranged from poor to excellent, with an average total sperm count of 1.1 × 109 and 50% morphologically normal spermatozoa (MNS). Age and abnormal testicular consistency correlated with decreased motility and MNS. Higher ALP correlated with higher total sperm count.. AMH could not be detected in seminal plasma. AMH in blood correlated with head defects and high AMH concentration correlated with a severe decline in several semen parameters. Testosterone was negatively and CPSE positively correlated with age. No correlations were found for INSL-3, inhibin B, or heterophilic antibodies. Our findings contribute to the understanding of factors associated with semen quality in dogs, particularly related to Sertoli cell function.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Correlation Between Biomarkers and Semen Qualitymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Endocrine and dog factors associated with semen quality

Hallberg,

Olsson,

Lau

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Testosterone is produced by the Leydig cell in response to the secretion of luteinizing hormone (LH) and is responsible to the development of male characteristics. The concentration of testosterone is lower in men with inferior sperm quality and decreases with age in both men and male dogs 5 , 6 . In the circulation, testosterone is largely protein-bound to albumin and more specifically sex-hormone binding globulin, SHBG, and only the free fraction of testosterone may exert biological effects 7 .…”

Section: Introductionmentioning

confidence: 95%

Endocrine and dog factors associated with semen quality

Hallberg,

Olsson,

Lau

et al. 2024

Sci Rep

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Knowledge of factors associated with semen quality may help in investigations of the aetiology and pathophysiology. We investigated the correlation between biomarkers for testicular cell function (anti-müllerian hormone, AMH, Inhibin B, testosterone, free androgen-index (testosterone/sex-hormone binding globulin), insulin like peptide 3, INSL-3), alkaline phosphate (ALP), canine prostate-specific esterase (CPSE), and heterophilic antibodies with dog variables, semen quality, and fertility. Blood and semen were collected from 65 Bernese Mountain Dogs. We evaluated total sperm count, motility and morphological parameters. The semen quality ranged from poor to excellent, with an average total sperm count of 1.1 × 109 and 50% morphologically normal spermatozoa (MNS). Age and abnormal testicular consistency correlated with decreased motility and MNS. Higher ALP correlated with higher total sperm count. AMH could not be detected in seminal plasma. AMH in blood correlated with head defects and high AMH concentration correlated with a severe decline in several semen parameters. Testosterone was negatively and CPSE positively correlated with age. No correlations were found for INSL-3, inhibin B, or heterophilic antibodies. Our findings contribute to the understanding of factors associated with semen quality in dogs, particularly related to Sertoli cell function.

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WSAVA guidelines for the control of reproduction in dogs and cats

Romagnoli,

Krekeler,

de Cramer

et al. 2024

J of Small Animal Practice

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2.1.3.1.2. Prevention and treatment of complications associated with prescrotal orchiectomy in dogs 2.1.3.1.3. Scrotal orchiectomy in dogs 2.1.3.1.4. Orchiectomy in dogs with scrotal ablation 2.1.3.2. Orchiectomy in dogs with cryptorchid testes 2.1.3.2.1. Cryptorchidectomy of an extra-inguinal testis 2.1.3.2.2. Cryptorchidectomy of an inguinal testis 2.1.3.2.3. Ventral midline laparotomy for cryptorchidectomy of an intra-abdominal testis 2.1.3.2.4. Laparoscopic cryptorchidectomy in dogs 2.1.4. Male cats 2.1.4.1. Orchiectomy in cats with descended testes 2.1.4.1.1. Scrotal orchiectomy in cats 2.1.4.2. Orchiectomy in cats with cryptorchid testes 2.1.4.2.1. Cryptorchidectomy of an extra-inguinal testis 2.1.4.2.2. Cryptorchidectomy of an inguinal testis 2.1.4.2.3. Ventral midline laparotomy for cryptorchidectomy of an intra-abdominal testis 2.2. Surgical sterilisation of dogs and cats with preservation of gonadal hormones 2.

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Age, weight and circulating concentrations of total testosterone are associated with the relative prostatic size in adult intact male dogs

Cited by 4 publications

References 44 publications

Endocrine and dog factors associated with semen quality

Endocrine and dog factors associated with semen quality

Endocrine and dog factors associated with semen quality

WSAVA guidelines for the control of reproduction in dogs and cats

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