Age-Stratified Prevalence and Predictors of Neoplasia Among U.S. Adults Undergoing Screening Colonoscopy in a National Endoscopy Registry

Liang, Peter S.; Williams, Jennie L.; Dominitz, Jason A.; Corley, Douglas A.; Zauber, Ann G.

doi:10.1053/j.gastro.2022.05.036

Cited by 18 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of feasibility issues, data on CRCs detected were not available, a minor limitation given the likely imprecise point estimates for any age category and for both reporting periods. Prevalence of any adenoma and advanced adenoma are broadly comparable with previous reports of screening colonoscopy in persons younger than 50 years, 9,15,16 with the limitation that these previous reports of screening colonoscopy in persons younger than 50 may have included a higherthan-average proportion of persons with 1 or more firstdegree relatives with CRC.…”

supporting

confidence: 81%

Uptake of Colorectal Cancer Screening in 45 to 49 Year Olds: An Early-Inning View from the Endoscopy Suite

Imperiale

2022

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

supporting

confidence: 81%

Uptake of Colorectal Cancer Screening in 45 to 49 Year Olds: An Early-Inning View from the Endoscopy Suite

Imperiale

2022

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…the ADR for two serial groups for this age range in a third study (Ladabaum et al, 2022) encompassed those similar numbers (22.0% in the first group and 34.3% in the second group). All of these studies had strikingly similar results with Liang et al's (2022) investigation: 28.3%, which is the largest analysis of colonoscopies on record (table 1).…”

supporting

confidence: 68%

“…Males consistently had more adenomas than females in each age group in three of the studies (Bilal et al, 2022;Liang et al, 2022;Shaukat et al, 2022), whereas neither crockett and Ladabaum (2022) nor Ladabaum et al (2022) reported ADRs by gender. Some practices where one gender may predominate might merit gender-based ADR determinations.…”

mentioning

confidence: 89%

“…Liang, Williams, Dominitz, Corley, and Zauber (2022) also analyzed the GIQuIC Registry but from January 1, 2010, to December 31, 2020. Because they analyzed 4 more years of data compared with Bilal et al (2022), their results are the largest analysis of colonoscopy data on individuals of average-risk and younger than 50 years.…”

Section: Adenoma Detection Rates For Ages 45–49 Yearsmentioning

confidence: 99%

See 1 more Smart Citation

Adenoma Detection Rate Benchmarks: An Updated Analysis

Morrow

Greenwald

2023

Gastroenterology Nursing

View full text Add to dashboard Cite

Early-onset colorectal cancer prompted organizations to reduce the recommended screening initiation age from 50 to 45 years. The American Society for Gastrointestinal Endoscopy Quality Assurance in Endoscopy Committee recommends 3 priority quality indicators for colonoscopy services. The adenoma detection rate is considered the most important measure with the established benchmark based upon studies of patients 50 years or older. The incidence of polyps increases with age, so this change has an as-yet-unknown effect on the new benchmark. Five studies were reviewed. Based upon the results, 45- to 50-year-old patients should be included in facilities' adenoma detection rate calculations using the currently recommended benchmarks of 25% for women and men combined, or 20% for women and 30% for men when the genders are calculated separately. Males consistently had more adenomas than females in each of the 3 studies that separated genders, a detail that might merit gender-based adenoma detection rate determinations in some practices. One study indicated caution is advised; it recommends males and females be calculated separately and different benchmarks be used for each gender. The adenoma detection rate has been shown to increase over time. More studies are needed to guide screening quality metrics.

show abstract

“…Exclusion criteria included patients with inflammatory bowel disease, known familial adenomatous polyposis or Lynch syndrome, 10 or more polyps at index colonoscopy, or prior CRC. A total of 150 patients with early-onset CRC were matched with patients with average-onset colon cancer (n = 75) and rectal cancer (n = 75) based on sex and indication for colonoscopy because these factors are known to influence colonoscopic findings . Matching cases for patients with early-onset CRC were identified by consecutive review of a list of randomly selected patients with average-onset CRC until an equivalent number of matched cases was obtained.…”

Section: Methodsmentioning

confidence: 99%

Synchronous Neoplasia Rates at Colonoscopic Diagnosis of Early-Onset vs Average-Onset Colorectal Cancer

2023

View full text Add to dashboard Cite

ImportanceThe incidence of early-onset colorectal cancer (CRC) (age, &lt;50 years) continues to increase globally within high-income countries.ObjectiveTo examine and compare rates of synchronous neoplasia found in patients at colonoscopic diagnosis of early-onset CRC with rates found at diagnosis of average-onset CRC.Design, Setting, and ParticipantsIn this multisite retrospective and cross-sectional study conducted at Mayo Clinic sites and in the Mayo Clinic Health System from January 1, 2012, to December 31, 2022, 150 randomly selected patients with early-onset CRC were identified from the electronic health record and matched with 150 patients with average-onset CRC based on sex and colonoscopic indication. Patients with known hereditary syndromes, past history of CRC, or inflammatory bowel disease were excluded.Main Outcomes and MeasuresColonoscopic findings (polyp size, number, site) and related histopathologic findings (adenoma, advanced adenoma, sessile serrated polyp) were analyzed in association with cancer clinicopathologic features and molecular data (mismatch repair status, KRAS, and BRAFV600E).ResultsAmong 300 patients (156 men [52%]), the median age at diagnosis was 43 years (IQR, 39-47 years) for those with early-onset CRC and 67 years (IQR, 57-76) for those with average-onset CRC. Overall, 85% of patients were symptomatic at CRC diagnosis. Cancer stage, grade, molecular features, body mass index, and family history did not differ significantly between these groups. Among patients with colon cancer, the overall prevalence of synchronous neoplasia was similar, yet advanced adenomas were 3 times more frequent in those with early-onset vs average-onset cancers (31 of 75 [41%] vs 10 of 75 [13%]; P &lt; .001). This difference was not associated with cancer stage or primary location. Among patients with rectal cancer, nonadvanced adenomas were less frequent among the early-onset group than the average-onset group (21 of 75 [28%] vs 36 of 75 [48%]), and although the prevalence of advanced adenomas was similar (11 of 75 [15%] vs 14 of 75 [19%]), they were more commonly located in the rectum (early onset, 5 of 11 [45%] vs average onset, 1 of 14 [7%]). Patients with early-onset cancer of the colon were significantly more likely than those with early-onset cancer of the rectum to have a synchronous advanced adenoma (31 of 75 [41%] vs 11 of 75 [15%]; P &lt; .001).Conclusions and RelevanceIn this cross-sectional study, synchronous advanced adenomas were more commonly found in patients with early-onset colon cancer compared with average-onset colon cancer, and they were distributed throughout the colon. In contrast, advanced adenomas were not increased in patients with rectal cancer and, when detected, were predominantly located in the rectum.

show abstract

Age-Stratified Prevalence and Predictors of Neoplasia Among U.S. Adults Undergoing Screening Colonoscopy in a National Endoscopy Registry

Cited by 18 publications

References 28 publications

Uptake of Colorectal Cancer Screening in 45 to 49 Year Olds: An Early-Inning View from the Endoscopy Suite

Uptake of Colorectal Cancer Screening in 45 to 49 Year Olds: An Early-Inning View from the Endoscopy Suite

Adenoma Detection Rate Benchmarks: An Updated Analysis

Synchronous Neoplasia Rates at Colonoscopic Diagnosis of Early-Onset vs Average-Onset Colorectal Cancer

Contact Info

Product

Resources

About