Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury

Yorifuji, Takashi; Tsuda, Toshihide; Kawakami, Norito

doi:10.1007/s00420-007-0179-y

Cited by 19 publications

(10 citation statements)

References 24 publications

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“…but due to the displacement at the active sites; mercury interfaces with the activity of the essential mineral. Symptons that can be caused by a deficiency of minerals displaced by mercury include: [29] [30]  Magnesium: irregular heartbeat, chocolate cravings, cramps, PMS, receding gums, elevated blood pressure, etc.  Iron: Anemia, fatigue etc.…”

Section: Mineral Displacementmentioning

confidence: 99%

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Biological Influences of Mercury on Living Organisms

Gaur¹,

Singh

et al. 2017

IJMBS

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Human Beings have been exposed to heavy metals for an immeasurable amount of time. The industrialization of work has dramatically increased the overall environmental load of heavy metal toxins to the point that our societies are dependent upon them for proper functioning. [1] Industry and commercial process have actively mined refined manufactured, burned and manipulated heavy metals compounds and for a number of reasons. Today heavy metals are abundant in our drinking water, air and soil, due to our increased use of these compounds. [2] They are present virtually every area of modern consumerism from construction materials to cosmetics, medicines, processed foods, fuel sources and personal care products. [3,4] It is very difficult for anyone to avoid exposure to any of the many harmful heavy metals that are prevalent in our environment. [5] While it does not appear that we are going to neither neutralise the threat of heavy metal toxicity in our communities nor decrease our utilisation of the many commercial goods, we can take steps to understand this threat and put into action policies of prevention and treatment that may help to lessen the negative impact created by these metals on our health. [6]

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Section: Mineral Displacementmentioning

confidence: 99%

“…Mental effects are among the most common due to mercury's strong affinity for the brain. Mercury inhibits the effects of certain neurotransmitters: [30] [33]  Dopamine: Controls pain, well being.…”

Section: Brain and Learningmentioning

confidence: 99%

Biological Influences of Mercury on Living Organisms

Gaur¹,

Singh

et al. 2017

IJMBS

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“…149 The International Agency for Research on Cancer evaluated the strength of evidence for carcinogenity of mercury in a standardized manner using data from animal and human studies. Methylmercury compounds are classified as possible carcinogens to humans (group 2B).…”

Section: Mercury In the Environmentmentioning

confidence: 99%

Mercury Exposure and Children's Health

Blüml¹,

McCarty

Steckling³

et al. 2010

Current Problems in Pediatric and Adolescent Health Care

418

222

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Acute or chronic mercury exposure can cause adverse effects during any period of development. Mercury is a highly toxic element; there is no known safe level of exposure. Ideally, neither children nor adults should have any mercury in their bodies because it provides no physiological benefit. Prenatal and postnatal mercury exposures occur frequently in many different ways. Pediatricians, nurses, and other health care providers should understand the scope of mercury exposures and health problems among children and be prepared to handle mercury exposures in medical practice. Prevention is the key to reducing mercury poisoning. Mercury exists in different chemical forms: elemental (or metallic), inorganic, and organic (methylmercury and ethyl mercury). Mercury exposure can cause acute and chronic intoxication at low levels of exposure. Mercury is neuro-, nephro-, and immunotoxic. The development of the child in utero and early in life is at particular risk. Mercury is ubiquitous and persistent. Mercury is a global pollutant, bio-accumulating, mainly through the aquatic food chain, resulting in a serious health hazard for children. This article provides an extensive review of mercury exposure and children’s health.

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“…A study on cancer mortality in three regions of Japan, contaminated with MeHg (Minamata and Ashikita communities with higher exposure than in Amasuka) was performed by Yorifuji et al (2007).…”

Section: Miscellaneous Endpointsmentioning

confidence: 99%

Collate the literature on toxicity data on mercury in experimental animals and humans (Part I – Data on organic mercury)

Hassauer

Kaiser

Schneider

et al. 2012

EFSA Supporting Publications

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It was the scope of this project to collate, compile and summarise the scientific literature on the toxicity of methyl mercury, inorganic mercury and total mercury in humans and experimental animals published since 2002 and not evaluated in former JECFA risk assessments. Epidemiological data on MeHg toxicity confirmed former findings on an association between prenatal exposure and developmental neurotoxicity. Recent findings also support an influence of methyl mercury on the cardiovascular and immune system. Existing epidemiological data reveal several shortcomings limiting their suitability for risk assessment. Developmental neurotoxicity seems to be the most critical effect of MeHg in animals. A LOAEL of 0.01 mg/kg b.w. per day has been reported in young mice for locomotor activity exposed in utero. Rats seem to be less sensitive towards this endpoint: a NOAEL of 0.04 mg/kg b.w. per day has been reported in this species for locomotor activity. Systemic effects other than neurotoxicity have been mostly observed at higher doses than those producing neurotoxicity. No qualified epidemiological data appropriate for the evaluation of the toxicity of inorganic mercury after oral intake have been identified due to several limitations of the studies, e.g. small study group, insufficient control for confounders, inadequate exposure assessment. Toxicological studies in experimental animals widely confirmed former findings with respect to the target organs (neuro-, liver-, kidney-, immune-and reproductive toxicity, oxidative stress). The animal studies indicate that there might be relevant toxicological effects (developmental toxicity, liver toxicity) of inorganic mercury at dose levels similar or below the BMDL 10 value used for the derivation of the existing PTWI. However, due to some limitations of the studies no final conclusions can be drawn from these studies and the findings need further confirmation.

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Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury

Cited by 19 publications

References 24 publications

Biological Influences of Mercury on Living Organisms

Biological Influences of Mercury on Living Organisms

Mercury Exposure and Children's Health

Collate the literature on toxicity data on mercury in experimental animals and humans (Part I – Data on organic mercury)

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