Age-Specific Sex-Based Differences in Anemia in Patients with Myocardial Infarction

Kanic, Vojko; Kompara, Gregor; Vollrath, Maja; Suran, David; Kanic, Zlatka

doi:10.1089/jwh.2018.7211

Cited by 10 publications

(15 citation statements)

References 31 publications

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“…The higher risk of relatively larger infarct size in patients with lower aHb levels can be explained by several physiological mechanisms. Low aHb levels increase the supply-demand mismatch of oxygen in the myocardium and worsen myocardial ischemia due to the compensatory increase in stroke volume and a faster heart rate [ 25 , 26 ]. Low aHb levels also lead to a redistribution of blood flow from the subendocardial to the subepicardial myocardial layers, and together this can trigger myocardial necrosis [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Untangling the relationship between hemoglobin, peak troponin level, and mortality in patients with myocardial infarction

Kanic

Kompara

Suran

et al. 2022

Bosn J of Basic Med Sci

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Patients with a history of myocardial infarction (MI) and lower admission hemoglobin (aHb) levels have a worse outcome than patients with higher aHb, but lower or similar peaks in enzymatic infarct size. Hemoglobin levels are positively correlated with body surface area (BSA), which is positively correlated with cardiac mass. We hypothesized that patients with lower aHb suffer comparatively greater myocardial injury. We examined the relationships between aHb, and troponin (Tn) normalized to BSA (Tn/BSA) and its association with 30-day mortality. Data from 6055 patients, who were divided into seven groups based on their aHb at 10g/L intervals, were analyzed, and the groups were compared. The relationships between aHb and Tn/BSA and between Tn/BSA and 30-day mortality were assessed. Patients with higher aHb levels had greater BSA (p<0.0001). A negative relationship between aHb and log10Tn/BSA was observed in the entire group, and in men and women separately (p<0.0001, p<0.0001, and p=0.013, respectively). The log10Tn/BSA value was associated with 30-day mortality in the entire group, and in men and women separately (p<0.0001, p=0.014, and p<0.0001, respectively). Our finding suggests that a similar peak Tn value in patients with lower aHb means comparatively greater myocardial injury relative to cardiac mass. This hypothesis helps to explain the worse outcomes in patients with lower aHb. According to our findings, troponin should be indexed to BSA to provide comparable information on cardiac injury relative to cardiac mass. Whether this relationship is causal remains to be clarified.

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Section: Discussionmentioning

confidence: 99%

Untangling the relationship between hemoglobin, peak troponin level, and mortality in patients with myocardial infarction

Kanic

Kompara

Suran

et al. 2022

Bosn J of Basic Med Sci

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“…An association of anemia with clinical outcomes has been previously reported in patients with acute coronary syndrome (ACS) and patients with heart failure. 24,25 The reasons for the abnormal values found were evaluated considering that a diagnosis of anemia represented an exclusion criterion and that reduced HGB levels were detected in 14 of 51 patients of our study's sample. It was found that surgery in the 48 hours before TTS onset and treatment for comorbidities with drugs that can affect blood count may have represented potential causes of anemia.…”

Section: Discussionmentioning

confidence: 99%

“…An association of anemia with clinical outcomes has been previously reported in patients with acute coronary syndrome (ACS) and patients with heart failure. 24,25…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Indices in Patients With Takotsubo Syndrome

Braschi

Frasheri

Lombardo

et al. 2023

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

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Background: Although the prognosis of patients with Takotsubo syndrome (TTS) is relatively favorable, serious complications may occur. This study aimed to investigate the relationship between blood parameters and the occurrence of in-hospital complications. Methods: Clinical charts of 51 patients with TTS were retrospectively evaluated, and data regarding blood parameters assessed during the first 24 hours of hospitalization were studied. Results: Levels of hemoglobin less than 13 g/dL in men and 12 g/dL in women (P < 0.01), levels of mean corpuscular hemoglobin concentration (MCHC) less than 33 g/dL (P = 0.01), and levels of red blood cell distribution width-coefficient of variation higher than 14.5% (P = 0.01) were significantly associated to the occurrence of major adverse cardiovascular events (MACE). Markers, such as, platelets to lymphocytes ratio, lymphocytes to monocytes ratio, neutrophils to lymphocytes ratio, and white blood cell count to mean platelet volume, were unable to differentiate patients with and without complications (P > 0.05). MCHC and estimated glomerular filtration rate were independent predictors of MACE. Conclusions: Blood parameters may have a role in the stratification risk of patients with TTS. Patients showing low levels of MCHC and decreased estimated glomerular filtration rate were more likely to have in-hospital MACE. This should encourage physicians to closely monitor blood parameters in patients with TTS.

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“…Signal detection was evaluated using reporting odds ratio (ROR) with 95% con dence interval (CI) using univariate logistic regression analysis, similar to previously reported results [22]. Adjusted ROR (aROR) for anemia was calculated by adjusting gender since female is more likely to develop anemia in adulthood [23][24][25]. The present study categorized age, body weight, and DPBW as binary variables based on the ndings of previous reports and median value: age (≥ 60 years or < 60 years, and ≥ 80 years or < 80 years), body weight (≥ 50 kg or < 50 kg), and DPBW (≥ 12 mg/kg or < 12 mg/kg) [26].…”

Section: Statistical Analysesmentioning

confidence: 99%

Analysis of Clinical Factors in Olaparib-related Anemia Using Adverse Drug Event Reporting Databases

et al. 2023

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Purpose: Anemia is one of the dose-limiting toxicities of olaparib. The global phase trial con rmed that anemia occurrence in Japanese was relatively high. The factors related to anemia in different nationalities remain unknown. Therefore, this study investigated the factors of olaparib-related anemia in real-world settings using an adverse event reporting system database.Methods: We used data from FDA Adverse Events Reporting System (FAERS) and Japanese Adverse Drug Event Report database (JADER) between 2018 and 2021. FAERS reports from Japan were collected to conduct subgroup analyses, which was de ned as FAERS-Japan. The endpoint was the occurrence of olaparib-related anemia. Disproportionality analysis was conducted to calculate reporting odds ratio (ROR), with a con dence interval of 95%. Adjusted ROR (aROR) was calculated to control for gender differences.Results: In FAERS and JADER, the daily olaparib dose per body weight (DPBW) ≥12 mg/kg was detected to be a positive signal for anemia occurrence (aROR; FAERS, p<0.001, p=0.009, and JADER,], p=0.034). Furthermore, FAERS reports con rmed that females with body weight <50kg, reports from Japan, concomitant use of drugs suppressing vitamin B 12 , and previous platinum treatment history were positive signals of olaparib-related anemia. FAERS-Japan also showed that body weight <50kg and previous platinum treatment history were positive signals for the anemia occurrence. Conclusion: High DPBW poses a signi cant risk of anemia. The co-administration of drugs suppressing vitamin B 12 and previous platinum treatment history are also important information to evaluate the risk of olaparib-related anemia.

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Age-Specific Sex-Based Differences in Anemia in Patients with Myocardial Infarction

Cited by 10 publications

References 31 publications

Untangling the relationship between hemoglobin, peak troponin level, and mortality in patients with myocardial infarction

Untangling the relationship between hemoglobin, peak troponin level, and mortality in patients with myocardial infarction

Erythrocyte Indices in Patients With Takotsubo Syndrome

Analysis of Clinical Factors in Olaparib-related Anemia Using Adverse Drug Event Reporting Databases

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