Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation

Yoo, Jae Ho; Kim, Hye Ok; Wha, Sun; Park, Chan Woo; Yang, Kwang Moon; Song, In Ok; Koong, Mi Kyoung; Kang, Inn Soo

doi:10.5653/cerm.2011.38.2.93

Cited by 53 publications

(35 citation statements)

References 15 publications

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“…The distribution of AMH concentrations in women with PCOS was quite different from that in women with regular menstruation, as has been previously reported by Yoo et al [10]. The mean serum AMH levels of 1,298 women (mean age, 34.4±0.1 year) with regular menstruation was 3.6±0.1 ng/mL and decreased with age (Figure 1A).…”

Section: Resultssupporting

confidence: 56%

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Can high serum anti-Müllerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients?

Hwang

Sung

Koo

et al. 2013

Clin Exp Reprod Med

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ObjectiveTo evaluate correlations between serum anti-Müllerian hormone (AMH) levels, phenotypes of polycystic ovary syndrome (PCOS), obesity, and metabolic parameters in patients with PCOS.MethodsA total of 175 patients with PCOS were diagnosed according to the Rotterdam Consensus were included. Exclusion criteria were age over 40, FSH>25 mIU/mL, and 17a-OHP>1.5 ng/mL. The Phenotypes of PCOS were divided into a severe form (oligo-anovulation, ANOV/hyperandrogenism/polycystic ovary morphology [PCOM]; n=59) and a mild form without HA (ANOV/PCOM, n=105). The serum AMH levels were classified into 3 groups (<5 vs. 5-10 vs. >10 ng/mL). Obesity was defined as body mass index (BMI) ≥25 kg/m2 (n=34).ResultsThe mean age was 25.9±5.7 year and mean AMH level was 10.1±5.4 ng/mL. The BMI (kg/m2) was higher in group 1 (24.2±6.3) than in group 2 (21.9±4.3, p=0.046) or group 3 (21.6±3.3, p=0.019). There was no difference among the three groups in age, menstrual interval, antral follicle counts, androgens, or other metabolic parameters. The obesity group showed significantly lower AMH (7.7±3.9 ng/mL vs. 10.7±5.6 ng/mL), p=0.004) and low-density lipoprotein levels (93.1±21.2 mg/dL vs. 107.5±39.3 mg/dL, p=0.031), and showed higher total T (0.74±0.59 ng/mL vs. 0.47±0.36 ng/mL, p=0.001), free T (2.01±1.9 vs. 1.04±0.8 pg/mL, p=0.0001), and free androgen index (6.2±7.9 vs. 3.5±3.0, p=0.003). After controlling for age factors and BMI, the serum AMH levles did not show any significant correlations with other hormonal or metabolic parmeters.ConclusionFor PCOS patients under the age 40, serum AMH is not negatively correlated with age. High serum AMH levels can not predict the phenotype of PCOS and metabolic disturbances in PCOS patients in the non-obese group. Further study might be needed to define the relation more clearly.

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Section: Resultssupporting

confidence: 56%

“…(A) In women with regular menstruation (Adapted from Yoo et al Clin Exp Reprod Med 2011;38:93-7 [10]). (B) In women with PCOS (in present study).…”

Section: Figurementioning

confidence: 99%

Can high serum anti-Müllerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients?

Hwang

Sung

Koo

et al. 2013

Clin Exp Reprod Med

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“…Yoo et al19 reported that the AMH levels are significantly correlated with the OV in Korean women with PCOS.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Volume in Korean Women with Polycystic Ovary Syndrome and Its Related Factors

et al. 2017

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ObjectivesThe aim of this study was to determine the relationship of ovarian volume (OV) to age, height, and weight in Korean young women with the polycystic ovary syndrome (PCOS) undergoing ultrasonography (US) and to investigate the relationship between ovarian follicle count and volume on US and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin.MethodsA total of 272 Korean nulliparous women aged 15 to 39 years who were newly diagnosed with PCOS at a university hospital were included in this study. Evaluation of the ovaries and measurement of OVs in all cases were randomly performed by ultrasound. The OV and follicle number (FN) were obtained in all cases.ResultsIn Korean women with PCOS, mean OV was 7.9 ± 3.6 cm3 (right) and 6.7 ± 3.1 cm3 (left). Mean FN in the PCOS group was 14.2 ± 4.6 (right) and 13.8 ± 4.3 (left). OV and ovarian FN were unrelated to patient weight, height and body mass index. The left ovarian FN was related to patient age. AMH levels ranged from 5.31 to 43.1 ng/mL and the mean level was 13.9 ± 7.2 ng/mL. Serum AMH was related to OV and FN, and serum total testosterone was related to FN in Korean women with PCOS.ConclusionsIn Korean nulliparous women with PCOS, OV was smaller than that in other ethnic groups and the right OV was larger than the left OV. Ovarian FN, AMH, testosterone are good markers for the diagnosis of PCOS in Korean women.

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“…19 The AMH has been studied in different populations. 13,[20][21][22][23] It is known that AMH levels are not altered in women using hormonal contraceptives. 24 Some studies have evaluated AMH levels in patients with cancer and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Anti-müllerian Hormone in Reproductive Age Women With Systemic Lupus Erythematosus

Velarde-Ochoa

Esquivel‐Valerio

Vega‐Morales

et al. 2015

Reumatología Clínica (English Edition)

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Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation

Cited by 53 publications

References 15 publications

Can high serum anti-Müllerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients?

Can high serum anti-Müllerian hormone levels predict the phenotypes of polycystic ovary syndrome (PCOS) and metabolic disturbances in PCOS patients?

Ovarian Volume in Korean Women with Polycystic Ovary Syndrome and Its Related Factors

Anti-müllerian Hormone in Reproductive Age Women With Systemic Lupus Erythematosus

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