Age-specific reference ranges for serum prostate-specific antigen

Anderson, James R.; Strickland, Daniel; Corbin, David E.; Byrnes, John A.; Zweiback, B.S. Eugene

doi:10.1016/s0090-4295(99)80158-7

Cited by 70 publications

(33 citation statements)

References 12 publications

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“…22 This fact led Oesterling et al 24 to develop age reference ranges for white men from Olmsted County, Minnesota. 24 Other groups [25][26][27][28] have reported normal reference ranges similar to theirs, all based on a predominantly white population of men without prostate cancer, and all designed so that the test would have 95% specificity.…”

Section: Introductionmentioning

confidence: 91%

Age-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients

Battikhi

2003

Prostate Cancer Prostatic Dis

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In this study, the normal distribution of total prostate-specific antigen (TPSA) and free prostate-specific antigen (FPSA) values and the appropriate reference ranges for prostate-specific antigen (PSA) in Jordanian patients were established; the values were then compared to those of other studies. Serum TPSA and FPSA levels in 1852 men with no diagnostic prostate cancer, as well as in patients whose PSA value was obtained as part of the clinical work-up of symptoms relating to nonneoplastic urologic conditions, were estimated during the period 1993-2001: 1561 (84.3%) were above 40 y of age or older. We studied the data as a function of age to determine the usefulness of measuring TPSA, FPSA, and their ratio as screening tests for prostate cancer risk patients. Using the 95th percentile, the recommended age-specific reference ranges of TPSA and FPSA values were as follows: for the age group 30-34 y, 2.3 and 0.51 ng/ml, respectively; for the age group 35-39 y, 2.9 and 0.59 ng/ml, respectively; for the age group 40-44 y, 3.2 and 0.63 ng/ml, respectively; for the age group 45-49 y, 3.75 and 0.71 ng/ml, respectively; for the age group 50-54 y, 3.8 and 0.83 ng/ml, respectively; for the age group 55-59 y 3.75 and 0.96 ng/ ml, respectively; for the age group 460 y old, 4.3 and 1.26 ng/ml, respectively. There was a continuous increase in TPSA and FPSA means and medians throughout the study period with a significant correlation (Po0.001, Po0.05) for TPSA and FPSA levels), respectively, and advancing age group. With regard to the ratios of FPSAto-TPSA for each age group we found no correlation between them. As a result, the appropriate upper limit of normal 95th percentile for all ratios was 0.23 for men for all ages. The establishment of appropriate reference ranges for TPSA and FPSA as well as ratios will allow the practicing urologist to incorporate these new parameters into diagnostic evaluation of men at risk for early, potentially curable prostate cancer.

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Section: Introductionmentioning

confidence: 91%

Age-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients

Battikhi

2003

Prostate Cancer Prostatic Dis

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“…Serum PSA was found to be elevated with age and was clearly shown in various studies conducted among Asian populations such as Chinese, south India, Koreans, Singaporeans, and Japanese [4,7,[13][14][15][16][17][18][19][20][21][22][23][24][25][26] Dubey concluded that in India there is no scientific rationale to advocate routine use of PSA for early detection of PC in Indian males due to low incidence of PC. But the importance to establish reference range of serum PSA for healthy south Indian males to interpret PSA result in benign as well as malignant disorders of prostate was given by Malati and Kumari [4].…”

Section: Discussionmentioning

confidence: 99%

Establishment of Age Specific Reference Range of Serum PSA Level among Healthy Indian Hindu and Muslim Males

Yadav¹

2014

Biochem Anal Biochem

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Aim: This study was aimed to investigate the racial and ethnic differences in age specific references range of serum Prostate Specific Antigen (PSA) among healthy Indian Hindu and Muslim males and its comparison with Asian population. Method:The present study was done at Medanta-The Medicity on 1300 adult Indian male patients who were visiting in the executive health checkup package. Out of 1300 subjects, 1060 healthy subjects were Hindus and 193 were Muslims without any prostate disease ranging from age 19-97 years, while rest 47 were excluded due to some urological diseases. Statistical analysis was carried out. Mean + SD, median and the central 95 percentile were calculated for each age group. Result:The age specific reference range of serum PSA values in healthy Hindu males is 0.69 ng/ml in those younger than 40 years; 0.83 ng/ml in 40-49 years; 1.13 ng/ml in 50-59 yrs group; 1.46 ng/ml in 60-69 yrs group; 1.83 ng/ml in men's older than 70 years age group. Whereas the age specific reference range of serum PSA values in healthy Muslim males is 0.86 in those younger than 40 years; 1.01 ng/ml in 40-49 years; 1.41 ng/ml in 50-59 yrs group; 1.70 ng/ml in 60-69 yrs group; 2.92 ng/ml in men's older than 70 years age group. Conclusion:Present study highlighted the age-specific reference range of serum PSA in Healthy Hindu Males are on lower side as compared to Muslim males. The data also suggested that the PSA levels are associated with increasing age.

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“…Assays for PSA have been marketed with an upper limit of normal of 4.0 ng/ml [3]. However, several investigators have demonstrated that for patients without clinically evident prostate cancer, serum PSA levels increase with increasing age and age-specific upper limits of normal have been proposed [3].…”

Section: Discussionmentioning

confidence: 99%

“…However, several investigators have demonstrated that for patients without clinically evident prostate cancer, serum PSA levels increase with increasing age and age-specific upper limits of normal have been proposed [3]. Anderson et al [3] have proposed age-specific ranges for PSA values which are: 1.5 ng/ml for patients 40-49, 2.5 ng/ml for patients 50-59, 4.5 ng/ml for patients 60-69, and 7.5 ng/ml for patients 70-79.…”

Section: Discussionmentioning

confidence: 99%

Prostatic Adenocarcinoma Diagnosed by Prostate-Specific Antigen Analysis of Pleural Fluid

Brown

Ginsberg²,

Harkaway³

1998

Urol Int

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Adenocarcinoma of the prostate may result in a malignant pleural effusion. However, most of these cases involve patients with either a known primary prostate cancer or radiographic evidence of pulmonary metastases. Occasionally, the initial diagnosis of prostate cancer is made because of prostate-specific antigen (PSA) staining cells in the pleural fluid. We report a case of adenocarcinoma of the prostate that was suspected only because of an elevated PSA in the pleural fluid in a patient who lacked malignant cytology, a history of prostate cancer, and radiographic evidence of pulmonary disease.

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Age-specific reference ranges for serum prostate-specific antigen

Cited by 70 publications

References 12 publications

Age-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients

Age-specific reference ranges for prostate-specific antigen (PSA) in Jordanian patients

Establishment of Age Specific Reference Range of Serum PSA Level among Healthy Indian Hindu and Muslim Males

Prostatic Adenocarcinoma Diagnosed by Prostate-Specific Antigen Analysis of Pleural Fluid

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