Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women: A nationwide Population-Based Study

Du, Xiaofang; Ding, Ting; Zhang, Hanwang; Zhang, Cuilian; Ma, Wenzhi; Zhong, Ying; Qu, Wei; Zheng, Jie; Liu, Yi; Li, Zhiying; Huang, Kecheng; Deng, Song; Ma, Liyuan; Yang, Jun; Jiang, Jingjing; Yang, Shuhong; Huang, Jia; Wu, Meng; Li, Fang; Lu, Yao; Luo, Aiyue; Wang, Shixuan

doi:10.1177/1933719115625843

Cited by 44 publications

(33 citation statements)

References 38 publications

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“…Consistent with this, age was reported to account for 84% variation of the number of follicles in a previous study of women aged less than 51 years (61). Our findings aligns with the majority of longitudinal and cross-sectional studies (8, 9, 27, 28, 36, 62–65) that reported an inverse association between age and AMH concentrations. With regard to the menstrual cycle, AMH concentrations are suggested not to exhibit the large fluctuations typical of other ovarian hormones before menopause.…”

Section: Discussionsupporting

confidence: 92%

“…Our statistically non-significant testosterone results are consistent with three studies (9, 43, 44) but not with five others that reported significant positive associations between AMH and testosterone (28, 42, 65, 85, 86). Similarly, our statistically non-significant androstenedione results are consistent with one study (44) but not with two others that reported positive associations (42, 86).…”

Section: Discussionsupporting

confidence: 83%

“…Of 11 studies that reported results from healthy women on the association of BMI with AMH concentrations (9, 27, 28, 31–33, 36, 41–44), seven reported no significant association (9, 27, 36, 41–44), whereas four observed a significant inverse association (28, 31–33). Our non-significant association between BMI and AMH is consistent with the results from most studies of healthy women.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, eight studies (9, 28, 42–44, 65, 85, 86) examined associations of AMH with testosterone, three with androstenedione (42, 44, 86), and two with SHBG (9, 86). Our statistically non-significant testosterone results are consistent with three studies (9, 43, 44) but not with five others that reported significant positive associations between AMH and testosterone (28, 42, 65, 85, 86).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported significantly lower AMH concentrations associated with oral contraceptive use (9, 24–27), higher body mass index (BMI) (28–33), earlier age at menarche (26, 27, 34, 35), parity (35), alcohol consumption (36), and smoking (27, 37, 38), but these associations have not been consistent in other studies (8–10, 26, 27, 35, 36, 39–44). Many earlier studies included women who were infertile or who had PCOS, which may have influenced associations and reduces generalizability more broadly to normal premenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

Jung

Allen

Arslan

et al. 2017

Fertility and Sterility

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Objective To identify reproductive, lifestyle, hormonal and other correlates of circulating anti-Müllerian Hormone (AMH) concentrations in mostly late premenopausal women Design Cross-sectional study Setting Nine cohorts that participated in the Prospective Study of AMH and Gynecologic Cancer Risk Patient(s) 671 premenopausal women not known to have cancer. Intervention(s) None Main Outcome Measure(s) AMH concentrations were measured in a single laboratory using the picoAMH enzyme-linked immunosorbent assay. Multivariable-adjusted median (and interquartile range) AMH concentrations were calculated using quantile regression for several potential correlates. Results Older women had significantly lower AMH concentrations (≥40, n=444 vs. <35 years, n=64, multivariable-adjusted median: 0.73 ng/mL vs. 2.52 ng/mL). AMH concentrations were also significantly lower among women with earlier age at menarche (<12, n=96 vs. ≥14 years, n=200: 0.90 ng/mL vs. 1.12 ng/mL) and among current users of oral contraceptives (n=27), compared to never or former users (n=468) (0.36 ng/mL vs. 1.15 ng/mL). Race, body mass index, education, height, smoking status, parity and menstrual cycle phase were not significantly associated with AMH concentrations. There were no significant associations between AMH concentrations and androgen or sex hormone-binding globulin concentrations or with factors related to blood collection (e.g., sample type, time, season, and year of blood collection). Conclusions Among premenopausal women, lower AMH concentrations are associated with older age, a younger age at menarche and currently using oral contraceptives, suggesting these factors are related to a lower number or decreased secretory activity of ovarian follicles.

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