Age specific neuroprotection of curcumin is through differential modulation of brain dopamine metabolism: Insights from Drosophila model of Parkinson’s disease
Mohamad Ayajuddin,
Abhik Das,
Sarat Yenisetti
Abstract:Epidemiological studies suggest a strong linkage between exposure to environmental toxins and onset of Parkinson’s disease (PD). Rotenone is a widely used pesticide and known inhibitor of mitochondrial complex I, that has been shown to induce Parkinsonian phenotypes in various animal models. Our laboratory has developed a rotenone mediated ALSS Drosophila model of PD which is critical to screen small molecules and identify molecular targets of dopaminergic neuroprotection for late-onset neurodegenerative disea… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.