Age-specific effects of 6-hydroxydopamine lesions of the rat medial prefrontal cortex on stress-induced c-fos expression in subcortical areas

Sui, Zhi Yan; Li, Chunrong; Huang, Guang‐Biao; Kwon, Young Bae; Kim, Kee-Won; Lee, Keon-Hak; Chung, Young‐Chul

doi:10.1016/j.pnpbp.2010.05.024

Cited by 2 publications

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“…The effects of social defeat stress on dopaminergic nerve fibers in the adolescent mice with 6-OHDA-induced mPFC injury may be more significant than in adult mice. Previous studies have reported that under constant stress conditions, significantly increased c-Fos protein expression and significantly decreased social interaction behavior was observed in mice with a 6-OHDA-induced mPFC injury that occurs during adolescence when compared with injuries sustained in adulthood ( Li et al, 2010 ; Sui et al, 2010 ).…”

Section: Discussionmentioning

confidence: 96%

Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex

Zhao

Gao

Huang

2021

Front. Behav. Neurosci.

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Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress.Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) injury to select for members of a “stress-susceptible group,” and observed the changes in their behavior and the expression of D1 and D2 dopamine receptors in the amygdala and hippocampus.Results: We observed that after chronic social defeat stress, 72.6% of the 6-OHDA lesioned mice exhibited stress response to aggressors, compared to 52.3% of the blank control group. Both the 6-OHDA lesion + social defeat and social defeat groups exhibited anxiety and depression-like behavior. However, social cognitive impairment in the mice from the 6-OHDA lesion + social defeat group was more significant and the D1 expression levels in the amygdala were significantly decreased.Conclusion: These results suggest that the reason that adolescent mice with cortical injury were highly sensitive to defeat stress and had more prominent social cognitive impairment may be the decreased selectivity of D1 in the amygdala.

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Section: Discussionmentioning

confidence: 96%