Age-specific cancer rates: a bird's-eye view on progress

Rizzi, Silvia; Wensink, Maarten Jan; Ahrenfeldt, Linda Juel; Christensen, Kaare; Lindahl-Jacobsen, Rune

doi:10.1016/j.annepidem.2020.04.007

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…These circumstances provide an incentive for research on the development of particular types of neoplastic changes and for veterinarians to conduct a more detailed clinical analysis of the possibility of a neoplasm occurring in a given patient, depending on its species, breed, sex, age, and the anatomical location examined. Such data is systematically collected and updated in human medicine (9,15,19,26). Appropriate human oncological databases are created on this subject, but none are in veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of tumours and tumour-like lesions in domestic and exotic animals from Lower Silesia and its surrounds in Poland in 2014–2017

Ciaputa¹,

Gach²,

Baranowski

et al. 2022

Journal of Veterinary Research

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Introduction An analysis of samples originating from domestic and exotic animals from Lower Silesia but also from other parts of Poland was carried out based on research conducted in 2014–2017. Material and Methods The materials used for the study were 11,338 tumour samples taken in vivo during surgery and as biopsies and posthumously during necropsies. They were sent to the Department of Pathology at Wrocław University of Environmental and Life Sciences for histopathological diagnosis. Results The largest group were canine tumours, of which there were 9,745 (85.95%), followed by feline tumours, totalling 1,397 (12.32%), tumours from exotic animals (186; 1.64%), from horses (7; 0.06%), and from cows (2; 0.02%). A significant number of cases of animals suffering from more than one tumour were also found, which had not been frequently diagnosed previously. Conclusion The number of neoplasms diagnosed in pets and exotic animals is increasing every year. The average animal age at diagnosis continues to fall. The greatest number of neoplasms were diagnosed in mixed-breed dogs and cats, and the number of tumours in a pure breed strictly correlated with breed’s popularity in the research period. Mesenchymal tumours are still the most prevalent type of tumours in dogs, while in cats epithelial tumours predominate. The neoplasm case pattern in animals conforms to that in humans in the same area.

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Section: Introductionmentioning

confidence: 99%

“…Such data is systematically collected and updated in human medicine ( 9 , 15 , 19 , 26 ). Appropriate human oncological databases are created on this subject, but none are in veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of tumours and tumour-like lesions in domestic and exotic animals from Lower Silesia and its surrounds in Poland in 2014–2017

Ciaputa¹,

Gach²,

Baranowski

et al. 2022

Journal of Veterinary Research

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“…El cáncer se ha definido como un conjunto de enfermedades heterogéneas caracterizadas por la presencia de alteraciones a nivel genético y epigenético que afectan los mecanismos celulares regulatorios y de homeostasis, tales como el crecimiento, la división y la diferenciación celular, entre otros (Ginsburg et al, 2020). Los factores que originan el cáncer han sido motivo de estudio durante varios años y se sabe que existen diferentes factores de riesgo involucrados en su desarrollo, tales como la edad (Rizzi et al, 2020), las infecciones virales (Golrokh Mofrad et al, 2020;Nelson & Benson, 2017), la exposición a radiación (Akbani et al, 2015), la exposición a contaminantes ambientales (Hwang et al, 2020), y la dieta (AlHilli & Bae-Jump, 2020;Lien & Vander Heiden, 2019), entre otros, siendo esta última un factor que ha adquirido gran importancia en los últimos años (Steck & Murphy, 2020), debido a que se ha observado que los cambios en la dieta pueden originar predisposición al desarrollo de cáncer, o por el contrario, ofrecer efectos protectores contra este padecimiento. Por tal motivo, el estudio sobre la influencia que tiene la dieta en el desarrollo de cáncer ha cobrado gran importancia actualmente.…”

Section: Cáncerunclassified

La Hologenómica y su relación con el cáncer

Arriaga-Canon¹,

Contreras-Espinosa²,

Manríquez³

et al. 2021

RECEIN

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Un holobionte es considerado una entidad biológica asociada en simbiosis con microorganismos que complementan sus vías metabólicas, sus funciones fisiológicas y su variación genética. El término hologenoma se refiere a todo el contenido genético del holobionte, es decir, a la suma del genoma del hospedero, sus organelos junto con los genomas del microbioma que lo componen. En la actualidad se ha establecido que existe una relación entre el desarrollo de enfermedades y el microbioma de los humanos, por lo que en esta revisión se describirá el papel del hologenoma en el cáncer y las técnicas de secuenciación masiva en paralelo aplicadas en la hologenómica. El estudio de la hologenómica junto con las tecnologías en secuenciación y bionformática proporcionará información relevante para el desarrollo de nuevas herramientas diagnósticas y su posterior aplicación en la práctica clínica.

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Healthy lifespan inequality: morbidity compression from a global perspective

2023

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Current measures of population health lack indicators capturing the variability in age-at-morbidity onset, an important marker to assess the timing patterns of individuals’ health deterioration and evaluate the compression of morbidity. We provide global, regional, and national estimates of the variability in morbidity onset from 1990 to 2019 using indicators of healthy lifespan inequality (HLI). Using data from the Global Burden of Disease Study 2019, we reconstruct age-at-death distributions to calculate lifespan inequality (LI), and age-at-morbidity onset distributions to calculate HLI. We measure LI and HLI with the standard deviation. Between 1990 and 2019, global HLI decreased from 24.74 years to 21.92, and has been decreasing in all regions except in high-income countries, where it has remained stable. Countries with high HLI are more present in sub-Saharan Africa and south Asia, whereas low HLI values are predominant in high-income countries and central and eastern Europe. HLI tends to be higher for females than for males, and HLI tends to be higher than LI. Globally, between 1990 and 2019 HLI at age 65 increased from 6.83 years to 7.44 for females, and from 6.23 to 6.96 for males. Improvements in longevity are not necessarily accompanied by further reductions in HLI among longevity vanguard countries. Morbidity is compressing, except in high-income countries, where it stagnates. The variability in the ages at morbidity onset tends to be larger than the variability in lifespans, and such divergence broadens over time. As longevity increases worldwide, the locus of health inequality is moving from death-related inequalities to disease- and disability-centered ones.

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Age-specific cancer rates: a bird's-eye view on progress

Cited by 4 publications

References 10 publications

Prevalence of tumours and tumour-like lesions in domestic and exotic animals from Lower Silesia and its surrounds in Poland in 2014–2017

Prevalence of tumours and tumour-like lesions in domestic and exotic animals from Lower Silesia and its surrounds in Poland in 2014–2017

La Hologenómica y su relación con el cáncer

Healthy lifespan inequality: morbidity compression from a global perspective

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