Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis

Karalexi, Maria A.; Dessypris, Nick; Ma, Xiaomei; Spector, Logan G.; Marcotte, Erin L.; Clavel, Jacqueline; Pombo‐de‐Oliveira, Maria S.; Heck, Julia E.; Roman, Eve; Mueller, Beth A.; Hansen, Johnni; Auvinen, Anssi; Lee, Pei‐Chen; Schüz, Joachim; Magnani, Corrado; Mora, Ana María; Dockerty, John D.; Scheurer, Michael E.; Wang, Rong; Bonaventure, Audrey; Kane, Eleanor; Doody, David R.; Erdmann, Friederike; Kang, Alice Y.; Metayer, Catherine; Milne, Elizabeth; Petridou, Eleni; Baka, Margarita; Moschovi, Maria; Polychronopoulou, Sophia; Kourti, Maria; Hatzipantelis, Emmanuel; Pelagiadis, Iordanis; Dana, Helen; Καντζάνου, Μαρία; Tzanoudaki, Marianna; Anastasiou, Theodora; Grenzelia, Maria; Gavriilaki, Eleni; Sakellari, Ioanna; Anagnostopoulos, Αchilles; Kitra, Vasiliki; Paisiou, Anna; Bouka, Evdoxia; Nikkilä, Atte; Lohi, Olli

doi:10.1016/j.ejca.2020.01.018

Cited by 8 publications

(10 citation statements)

References 59 publications

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“…By contrast, the evidence on the association between birth weight and childhood AML is more heterogeneous with both pooled and meta-analyses suggesting a U-shaped association [17,29,31]. However, a recent CLIC study found a positive association for AML with high birth weight and with being large-for-gestational-age but no indication of a U-shaped association [42].…”

Section: Results In the Context Of Previous Studiesmentioning

confidence: 97%

Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study

Lupatsch

Kreis

Konstantinoudis

et al. 2021

Cancer Causes Control

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Purpose Initial genetic alterations in the development of childhood leukemia occur in utero or before conception; both genetic and environmental factors are suspected to play a role. We aimed to investigate the associations between childhood leukemia and perinatal characteristics including birth order, birth interval to older siblings, parental age, birth weight, and multiple birth. Methods We identified cases diagnosed between 1981 and 2015 and born in Switzerland between 1969 and 2015 from the Swiss Childhood Cancer Registry and randomly sampled five controls per case from national birth records matched on date of birth, sex, and municipality of residence at birth. We used conditional logistic regression to investigate associations between perinatal characteristics and leukemia at ages 0–15 and 0–4 years, and the subtypes acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Results The study included 1,403 cases of leukemia. We observed increased risks associated with high birth weight (adjusted OR 1.37, 95% CI 1.12–1.69) and multiple birth (1.89, 1.24–2.86). These associations were similar for ALL and stronger for leukemia at ages 0–4 years. For AML, we observed an increased risk for higher birth order (3.08, 0.43–22.03 for fourth or later born children). We found no associations with other perinatal characteristics. Conclusion This register-based case–control study adds to the existing evidence of a positive association between high birth weight and risk of childhood leukemia. Furthermore, it suggests children from multiple births are at an increased risk of leukemia.

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Section: Results In the Context Of Previous Studiesmentioning

confidence: 97%

Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study

Lupatsch

Kreis

Konstantinoudis

et al. 2021

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…It was established in 2007 with the goal of overcoming the limitations of single epidemiological studies and allowing the assessment of relatively infrequent potential risk factors, including specific nonchromosomal birth defects. Further comprehensive descriptions of CLIC have been published previously 25‐31 …”

Section: Methodsmentioning

confidence: 99%

“…We used logistic regression models to calculate odds ratios (OR) and 95% confidence intervals (CI) for each birth defect‐leukemia combination, while adjusting for the following variables: study site, sex, birthweight (<2500; 2500‐3999; >3999 g), gestational age (preterm [<37 weeks]; term [≥37 weeks]), maternal age (<25; 25‐29; 30‐34; 35‐39; ≥40 years), birth year and child's ethnicity (non‐Hispanic White; non‐Hispanic Black; Hispanic; and other —these categories varied by study and were harmonized based on previous CLIC assessments) 29,30,36 . These variables were selected based on previous assessments and to be consistent with other studies evaluating associations between nonchromosomal birth defects and pediatric cancer 10,26‐31 . Additionally, the categorical variables were designed similarly to what was used in previous CLIC assessments 27‐30 .…”

Section: Methodsmentioning

confidence: 99%

“…29,30,36 These variables were selected based on previous assessments and to be consistent with other studies evaluating associations between nonchromosomal birth defects and pediatric cancer. 10,[26][27][28][29][30][31] Additionally, the categorical variables were designed similarly to what was used in previous CLIC assessments. [27][28][29][30] However, unadjusted ORs and 95% CIs were also calculated and presented.…”

Section: Methodsmentioning

confidence: 99%

“…Further comprehensive descriptions of CLIC have been published previously. [25][26][27][28][29][30][31]…”

Section: Childhood Cancer and Leukemia International Consortiummentioning

confidence: 99%

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Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium

Lupo,

Chambers,

Mueller

et al. 2023

Intl Journal of Cancer

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Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire‐based and three registry‐based case‐control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia. Our analyses included acute lymphoblastic leukemia (ALL, n = 13 115) and acute myeloid leukemia (AML, n = 2120) cases, along with 46 172 controls. We used the false discovery rate to account for multiple comparisons. In the questionnaire‐based studies, the prevalence of birth defects was 5% among cases vs 4% in controls, whereas, in the registry‐based studies, the prevalence was 11% among cases vs 7% in controls. In pooled adjusted analyses, there were several notable associations, including (1) digestive system defects and ALL (OR = 2.70, 95% CI: 1.46‐4.98); (2) congenital anomalies of the heart and circulatory system and AML (OR = 2.86, 95% CI: 1.81‐4.52) and (3) nervous system defects and AML (OR = 4.23, 95% CI: 1.50‐11.89). Effect sizes were generally larger in registry‐based studies. Overall, our results could point to novel genetic and environmental factors associated with birth defects that could also increase leukemia susceptibility. Additionally, differences between questionnaire‐ and registry‐based studies point to the importance of complementary sources of birth defect phenotype data when exploring these associations.

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Fetal growth and pediatric cancer: A pan‐cancer analysis in 7000 cases and 37 000 controls

Hoang

Schraw

Peckham‐Gregory

et al. 2023

Intl Journal of Cancer

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Birth weight is an established risk factor for some pediatric cancers but is dependent on gestational age and sex. Furthermore, it is unclear how associations may differ by infant sex, age at diagnosis, maternal race/ethnicity and maternal nativity status. We examined the association between size for gestation and a spectrum of pediatric cancers registered in the Texas Cancer Registry from 1995 to 2011. We analyzed up to 7547 cases and 37 735 controls. Analyses were conducted using logistic regression. Small‐for‐gestational age (SGA) and large‐for‐gestational age (LGA) were significantly associated with several tumors. SGA was associated with hepatic tumors (aOR = 1.76, 95% CI: 1.13, 2.74). Conversely, inverse associations were with Hodgkin lymphoma (aOR = 0.41, 95% CI: 0.19, 0.87) and soft tissue sarcomas (aOR = 0.65, 95% CI: 0.43, 0.97). LGA was associated with acute lymphoblastic leukemia (aOR = 1.37, 95% CI: 1.19, 1.57), Burkitt lymphoma (aOR = 1.90, 95% CI: 1.05, 3.45) and germ cell tumors (aOR = 1.55, 95% CI: 1.08, 2.23). Results did not differ when stratified by infant sex. The association with LGA and leukemia was strongest in those diagnosed 1 to 5 and 6 to 10 years. When stratified by maternal race/ethnicity, the association with LGA and neuroblastoma and renal tumors was strongest in children whose mother identified as non‐Hispanic/Latina (H/L) Black. Among H/L women, children of Mexican‐born women had a stronger association with LGA and leukemia, CNS tumors, neuroblastoma and renal tumors than children of US‐born women (aOR range: 1.61‐2.25 vs 1.12‐1.27). Size for gestation is associated with several pediatric cancers. Associations may differ by age at diagnosis, maternal race/ethnicity and nativity.

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Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis

Cited by 8 publications

References 59 publications

Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study

Birth characteristics and childhood leukemia in Switzerland: a register-based case–control study

Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium

Fetal growth and pediatric cancer: A pan‐cancer analysis in 7000 cases and 37 000 controls

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