Age Resistance of Mice to Trypanosoma cruzi

Culbertson, James T.; Kessler, Walter R.

doi:10.2307/3272728

Cited by 19 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of hormones to males or females during infection was not found to alter the course of the disease (10), and the basis of the sex-related resistance re- mains undetermined. Mice have also been found to increase in resistance as they grow older, but the factors involved are again unknown (9).…”

Section: Resultsmentioning

confidence: 99%

Genetics of murine resistance to Trypanosoma cruzi

Trischmann¹,

Bloom²

1982

Infect Immun

View full text Add to dashboard Cite

Resistance to the protozoan parasite Trypanosoma cruzi is governed by multiple genetic factors, including at least one coded for by a locus in or neat the major histocompatibility complex of the mouse. The influence of the H-2 locus on resistance was evident when H-2 congenic mice on a strain background of intermediate resistance were challenged or when the survival of H-2 typed F2 mice was followed. The H-2k haplotype of the susceptible C3H/An strain was associated with higher mortality when compared with the H-2b haplotype of the resistant C57BL/10 strain. Genetic studies showed that resistance was a dominant trait and increased with genetic heterozygosity. Fl mice derived from crosses between resistant and susceptible strains, or even between two susceptible strains, were much more resistant than either parent. Crosses between two resistant strains, C57BL/6J and DBA/2J, led to resistant progeny in the Fl and F2 generations; but when recombinant inbred strains derived from these parental strains were challenged, susceptible strains were identified, indicating that different genes were responsible for resistance in the two strains.

show abstract

Section: Resultsmentioning

confidence: 99%

Genetics of murine resistance to Trypanosoma cruzi

Trischmann¹,

Bloom²

1982

Infect Immun

View full text Add to dashboard Cite

show abstract

“…We used a low T. cruzi inoculum size (50 trypomastigotes) to prevent a high mortality rate, since young mice are more susceptible than adults (37). The parasitemia levels were higher in WT male (Figure 2A, left panel) as compared to WT female mice (Figure 2B, left panel), in accordance with the known higher susceptibility of male animals (38).…”

Section: Resultsmentioning

confidence: 99%

“…As mentioned above, the age of the mice is important for the resultant parasitemia and for the severity of the disease symptoms (37). Moreover, Ly49E expression weakens with age (26, 28).…”

Section: Resultsmentioning

confidence: 99%

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection

et al. 2016

View full text Add to dashboard Cite

The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase. Natural killer (NK) and NKT cells play an important role in the immune control of T. cruzi infection, mainly by releasing the cytokine IFN-γ that activates the microbicidal action of macrophages and other cells and shapes a protective type 1 immune response. The mechanisms by which immune cells are regulated to produce IFN-γ during T. cruzi infection are still incompletely understood. Here, we show that urokinase plasminogen activator (uPA) is induced early upon T. cruzi infection and remains elevated until day 20 post-infection. We previously demonstrated that the inhibitory receptor Ly49E, which is expressed, among others, on NK and NKT cells, is triggered by uPA. Therefore, we compared wild type (WT) to Ly49E knockout (KO) mice for their control of experimental T. cruzi infection. Our results show that young, i.e., 4- and 6-week-old, Ly49E KO mice control the infection better than WT mice, indicated by a lower parasite load and less cachexia. The beneficial effect of Ly49E depletion is more obvious in 4-week-old male than in female mice and weakens in 8-week-old mice. In young mice, the lower T. cruzi parasitemia in Ly49E KO mice is paralleled by higher IFN-γ production compared to their WT controls. Our data indicate that Ly49E receptor expression inhibits the immune control of T. cruzi infection. This is the first demonstration that the inhibitory Ly49E receptor can interfere with the immune response to a pathogen in vivo.

show abstract

“…The data obtained for parasitemia present significant differences and tendency observed in other studies recently carried out 3 , in which the animals which are submitted to physical training and then to infection respond better to the infectious agent. Sex 22 , age 23 and genetic constitution of the host can influence the infection course by the T. cruzi in vertebrates 24 . The genetic response of each strain and sex present interesting points to be elucidated in further research approaching the immunegenetics involved in defense mechanisms of the animals.…”

Section: Discussionmentioning

confidence: 99%

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Soares

Franzói-de-Moraes

et al. 2012

Rev Bras Med Esporte

View full text Add to dashboard Cite

Background: Chagas disease is an infection caused by Trypanosoma cruzi that affects eight million people in Latin America. One factor linked to the lifestyle that significantly interferes in the response to infection is physical exercise, depending on the kind, intensity and frequency of the activity practiced. Objective: To evaluate the influence of pre-infection chronic moderate aerobic exercise in the development of experimental infection with T. cruzi in mice of two distinct lineages from both sexes. Methods: 30-day old Swiss and BALB/c mice (male and female) were divided into four groups for each strain and sex (total 16) and named as follows: SM (Swiss males), SF (Swiss females) BM (BALB/c mice) and BF (BALB/c mice). The groups were: NT NI (untrained uninfected) T NI (trained not infected); NT I (untrained infected), TI (trained infected). The aerobic exercise pre-moderate chronic infection training was performed with one daily session for eight weeks, five times a week. The inoculum was 1,400 blood trypomastigotes of Y strain of T. cruziintraperitoneally. The peak of parasites, parasitemia total and average measurements of the serum activities of CK and CK-MB were evaluated. Results and Conclusions: The physical training promoted reduction in peak, parasitemia parasites and total average in animals infected with T. cruzi in both strains and sexes. Physical training induced reduction in serum activities of CK and CK-MB in animals infected with T. cruzi of both sexes and from the two strains, except for females in the Swiss CK activity.

show abstract

Age Resistance of Mice to Trypanosoma cruzi

Cited by 19 publications

References 2 publications

Genetics of murine resistance to Trypanosoma cruzi

Genetics of murine resistance to Trypanosoma cruzi

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Contact Info

Product

Resources

About